Riedel's thyroiditis is a rare disease classified as a special type of chronic thyroiditis. However, there are few reports about this illness, and many problems with its pathogenesis and ...classification exist. A 65-year-old man with hypothyroidism underwent right lobectomy of the thyroid gland on the basis of a diagnosis of thyroid cancer. because of enlargement of hard goiter, swelling of many cervical lymph nodes, and an invasive shadow with calcification upon echography and CT. However operative findings and a pathological investigation suggested Riedel's thyroiditis. Fibrous invasion of the connective tissue or organs surrounding the thyroid gland is pathologically the most characteristic finding of this disease, which occasionally has specific complications, such as multiple fibrosis. Thus, in some papers it is stated that this disease is independent of chronic thyroiditis. However, autoimmunological factors i the pathogenesis are recognized, and there are many points of similarity between Riedel's and chronic thyroiditis. In the future, it will be important to conduct investigations into both diseases.
Effects of added elements on the intergranular cracking susceptibility of 9%Ni cast steel were investigated. Three series of experiments I to III were carried out. In the series I relation between Ni ...content and crack susceptibility was examined. By increasing Ni content the steel became embrittled and bending test pieces were readily fractured at a small degree of bending. Microstructural study revealed intergranular cracking already present in the as cast state. In the series II effects of additional elements on crack prevention were studied. Cr, V, Mg, Mo, Zr and Ce were examined to find Zr and Ce effective. In the series III contents of Zr and Ce were changed, further confirming their effects of preventing intergranular cracking. The effect of the two elements was related to the structural refinement occurring on their addition.
A computer system plays an indispensable role not only for correctly filing information of the radiographic and endoscopic diagnoses but also for referring to cases which should be placed on ...follow-up examination. It is also the best tool for a comparative study of the radiographic and endoscopic diagnoses. Modification of IRD (Index for Roentgen Diagnoses) was attempted in order to use the computer system for processing information of radiographic and endoscopic diagnoses of the gastrointestinal tracts, based on the result of the past year. IRD consists of anatomical fields and pathological fields. In this paper the anatomical fields are called "location codes" and pathological fields are called, "diagnosis codes". The main points of the modification are as follows. 1) Modification of the location codesCodes expressing the anterior wall, posterior wall, lesser curvature and greater curvature were made by adding a forth digit. A code for anastomosis and sature line was added. 2) Modification of diagnosis codesCodes expressing peptic ulcer were largely modified in order to reveal the present situation of radiographic and endoscopic diagnosis in Japan. Codes for erosion (s) were added. Codes for malignant neoplasm were vastly modified, following the classifications of Borrmann and early gastric cancer which should be used for cancer of the entire gastrointestinal tracts. A year of actual use and testing at our hospital has proven that the modified IRD is useful and practical on the computer. Establishment of the coding system for the diagnoses is very important as the first step of installing the computer system.
Screen layout for data input was described, based on the modified IRD, and an outline of system esign was also described. Computer used in this study is IBM System/34. Input data include patient ID, ...name, year of birth, age and sex as a master file. It also includes necessary items for information of endoscopic examination such as date of examination, endoscope used, kinds of premedication and its side effect, etc. As to inormation of the diagnosis, performance of biopsy and/or polypectomy, number of biopsy fragment, size of polypectomized specimen, pathologic diagnosis of biopsy and/or poly pectomy, number of cancer-positive fragment are described in one step, in addition to the main diagnosis by the modified IRD. In the system design, various kinds of follow-up program for patients are includid. It also consists of many output programs including individual list of the diagnosis, list of number and case of each diagnosis, corresponding list of radiographic and endoscopic diagnoses, etc. Emphasis was laid upon the importance of mutual cooperation among doctors, system engineer and programer in the process from installment plan of computer to its system design.
For the two-phase slug flow in the vertical tube, a simple flow model was proposed, by means of which the quantities defined in the previous report were theoretically correlated. A series of ...experiments was carried out, and it was proved that the actual slug flow could be fundamentally represented by the proposed flow model. Also the two-phase discharge coefficient of the orifice was defined and experimentally correlated with the component volume flow. It was found that the component flows could be estimated by measuring the average pressure drop across the orifice and the time ratio or the void ratio.
Cefprozil (CFPZ, BMY-28100) granule preparation was studied for pharmacokinetic, bacteriological and clinical aspects in the pediatric infections. The results obtained are summarized as follows: 1. ...Serum concentrations and urinary excretion. The pharmacokinetics of CFPZ in pediatrics was investigated by single oral administration of fine granules at doses of 4.0, 7.5 and 15.0 mg/kg. Peak blood levels of CFPZ were 3.06, 4.62 and 9.65 micrograms/ml, respectively, at 1.00-1.30 hours after each dose and AUCs were 7.44, 12.50 and 27.01 micrograms.hr/ml, respectively. These data showed that Cmax and AUC depended on dose levels. T 1/2 (beta) at these dose levels were 1.03, 0.94 and 1.01 hours, respectively. There were no differences related to dose. Urinary recovery rates in the first 6 hours after administration were 51.5-57.1%. The pharmacokinetics of CFPZ before or after meals were also investigated at a dose of 7.5 mg/kg. Peak blood levels were 4.88 micrograms/ml at 1.17 hours after administration in the fasting state, and 4.30 micrograms/ml at 1.54 hours after administration in the non-fasting state. Delay of Tmax and slight decrease of Cmax were observed in the non-fasting state, but T 1/2 and AUC were 0.91 hour and 12.96 micrograms.hr/ml, respectively, in the non-fasting state, and were similar to those in the fasting state, 0.93 hour and 12.82 micrograms.hr/ml, respectively. Urinary recovery rates in the first 6 hours after administration were 63.8% in the fasting state and 50.7% in the non-fasting state. 2. Clinical results. Clinical efficacies of CFPZ granules in various infectious diseases were studied in 804 cases. Twenty nine cases, mostly viral or mycoplasmal infections, were excluded from the statistical analysis. The clinical efficacy rate in 527 cases with causative bacteria isolated was 97.2%; and in 248 cases from whom no significant isolate had been obtained was 96.0%. The clinical efficacy rate in 475 cases with monobacterial infections (proven by culture of isolates) was 97.3%, and that in 52 case with polybacterial infections was 96.2%. Haemophilus influenzae was isolated mostly from acute respiratory infections. In 88 cases from whom H. influenzae was isolated, clinical efficacy rate was 95.5%. In cases from whom H. influenzae was found concomitant by with Staphylococcus aureus, Streptococcus pyogenes or Streptococcus pneumoniae, the clinical efficacy rates were also high. The bacteriological eradication rate in cases with 582 strains was 83.3%; the eradication rate for Gram-positive organisms was 95.8%; and for Gram-negative organisms, it was 64.2%.(ABSTRACT TRUNCATED AT 400 WORDS)
Recently we managed a case of Ménétrier's disease accompanied by marked hypoproteinemia. This 49-year-old male had undergone roentgenologic examination of the stomach at other hospital in 1977 and ...1978, which revealed no abnormalities. The patient came to the Department of Internal Medicine of Cancar Institute Hospital for the first time in October of 1979, complaining of vomiting as well as edema of the upper and lower extremities, and was admitted on November 13-th. The blood test showed marked hypoproteinemia (3.8 g/dl). Roentgenologic and endoscopic examination of the stomach revealed thickened and tortuous mucosal folds of the corpus and antrum, and there were multiple surface erosions on the mucosal folds. Histopathologic findings by means of endoscopic polypectomy in the thickened portion of the mucous membrane revealed primarily hyperplasia of the fovelolar epithelium accompanied by the atrophy of the gastric gland. A diagnosis of Menetrier's disease accompanied by hypoproteinemia was made, and total gastrectomy was performed on January 23-th in 1980. Histologic examination of the resected stomach demonstrated co-existent polyadenomas en nappe and polypeux, and it was considered to correspond to Case No. 4 of the Ménétrier's original book. The hypoproteinemia was improved postoperatively and follow-up observations are being made at present on the patient at the Outpatient Department.
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