The Dead Sea Deep Drilling Project drilled 456 meters into the deepest floor of the Dead Sea and recovered a record of the past ∼220 kyr of the Levant hydroclimate history, that is, Marine Isotope ...Stages 1–7, including the last three interglacials and the last two glacials. We present an updated chronology of the core from DSDDP Hole 5017-1-A, from the Dead Sea’s deepest basin, that refines our previous chronology (Torfstein et al. 2015) based on new information. The updated chronology uses the following approaches: (1) radiocarbon ages of Kitagawa et al. (2017); (2) correlation of specific layers in the core with U–Th-dated sediments on the Dead Sea margin, particularly during the interval of glacial Lake Lisan (MIS 2,3,4); (3) tuning of the δ18O data of DSDDP core aragonite to the U–Th dated oxygen isotopes of regional cave speleothems; and (4) tuning of the DSDDP aragonite δ18O data to summer insolation curves when the cave δ18O chronology is less clear. The updated chronology reveals a strong relationship between the sedimentary facies comprising the core and Northern Hemisphere summer insolation variations. It shows that sequences of sediments marking drier/wetter/drier climate conditions in the lake’s watershed (e.g., salt/muds/salt, respectively) appear across the flank/peak/flank segments of several summer insolation peaks. In particular, the transition from drier to wetter sedimentary facies during mid-latitude insolation peaks coincides with the intervals of sapropel conditions in the Mediterranean, reflecting enhanced Nile flow due to intense African monsoonal conditions, and marking the impact of the tropical precession cycles on Eastern Mediterranean hydroclimate. This pattern was lost during MIS 2,3,4, when mostly sequences of primary aragonite are punctuated by gypsum precipitation during Heinrich events, marking the strong impact of the North Atlantic on the last glacial Levant hydroclimate.
•Updated chronology of the ICDP Dead Sea drill core DSDDP Hole 5017-1-A.•Strong relationships persist between the core’s sedimentary facies and NH summer insolation.•Interglacial arid conditions occurred during intervals of enhanced changes in insolation.•Interglacial Levant wetter conditions coincide with Mediterranean sapropels and other NH summer insolation peaks.
The structures of the ion-pairs formed in aqueous NaOH and LiOH solutions are elucidated by combining Raman multivariate curve resolution (Raman-MCR) experiments and ab initio molecular dynamics ...(AIMD) simulations. The results extend prior findings to reveal that the initially formed ion-pairs are predominantly water-shared, with the hydroxide ion retaining its full first hydration-shell, while direct contact ion-pairing only becomes significant at higher concentrations. Our results confirm previous experiments and simulations indicating greater ion-pairing in aqueous LiOH than NaOH as well as at high temperatures. Our results further imply that NaOH and LiOH ion-pairing free energies have an approximately linear (rather than square-root) dependence on ion concentration (in the molar range), with positive enthalpies and entropies that increase with concentration, thus implying that water-mediated interactions enthalpically disfavor and entropically favor ion-pair formation.
To evaluate the effects of administering chemotherapy following surgery, or following surgery plus radiotherapy (known as adjuvant chemotherapy) in patients with early stage non-small cell lung ...cancer (NSCLC),we performed two systematic reviews and meta-analyses of all randomised controlled trials using individual participant data. Results were first published in The Lancet in 2010.
To compare, in terms of overall survival, time to locoregional recurrence, time to distant recurrence and recurrence-free survival:A. Surgery versus surgery plus adjuvant chemotherapyB. Surgery plus radiotherapy versus surgery plus radiotherapy plus adjuvant chemotherapyin patients with histologically diagnosed early stage NSCLC.(2)To investigate whether or not predefined patient subgroups benefit more or less from cisplatin-based chemotherapy in terms of survival.
We supplemented MEDLINE and CANCERLIT searches (1995 to December 2013) with information from trial registers, handsearching relevant meeting proceedings and by discussion with trialists and organisations.
We included trials of a) surgery versus surgery plus adjuvant chemotherapy; and b) surgery plus radiotherapy versus surgery plus radiotherapy plus adjuvant chemotherapy, provided that they randomised NSCLC patients using a method which precluded prior knowledge of treatment assignment.
We carried out a quantitative meta-analysis using updated information from individual participants from all randomised trials. Data from all patients were sought from those responsible for the trial. We obtained updated individual participant data (IPD) on survival, and date of last follow-up, as well as details of treatment allocated, date of randomisation, age, sex, histological cell type, stage, and performance status. To avoid potential bias, we requested information for all randomised patients, including those excluded from the investigators' original analyses. We conducted all analyses on intention-to-treat on the endpoint of survival. For trials using cisplatin-based regimens, we carried out subgroup analyses by age, sex, histological cell type, tumour stage, and performance status.
We identified 35 trials evaluating surgery plus adjuvant chemotherapy versus surgery alone. IPD were available for 26 of these trials and our analyses are based on 8447 participants (3323 deaths) in 34 trial comparisons. There was clear evidence of a benefit of adding chemotherapy after surgery (hazard ratio (HR)= 0.86, 95% confidence interval (CI)= 0.81 to 0.92, p< 0.0001), with an absolute increase in survival of 4% at five years.We identified 15 trials evaluating surgery plus radiotherapy plus chemotherapy versus surgery plus radiotherapy alone. IPD were available for 12 of these trials and our analyses are based on 2660 participants (1909 deaths) in 13 trial comparisons. There was also evidence of a benefit of adding chemotherapy to surgery plus radiotherapy (HR= 0.88, 95% CI= 0.81 to 0.97, p= 0.009). This represents an absolute improvement in survival of 4% at five years.For both meta-analyses, we found similar benefits for recurrence outcomes and there was little variation in effect according to the type of chemotherapy, other trial characteristics or patient subgroup.We did not undertake analysis of the effects of adjuvant chemotherapy on quality of life and adverse events. Quality of life information was not routinely collected during the trials, but where toxicity was assessed and mentioned in the publications, it was thought to be manageable. We considered the risk of bias in the included trials to be low.
Results from 47 trial comparisons and 11,107 patients demonstrate the clear benefit of adjuvant chemotherapy for these patients, irrespective of whether chemotherapy was given in addition to surgery or surgery plus radiotherapy. This is the most up-to-date and complete systematic review and individual participant data (IPD) meta-analysis that has been carried out.
The effects of spinal anesthesia as compared with general anesthesia on the ability to walk in older adults undergoing surgery for hip fracture have not been well studied.
We conducted a pragmatic, ...randomized superiority trial to evaluate spinal anesthesia as compared with general anesthesia in previously ambulatory patients 50 years of age or older who were undergoing surgery for hip fracture at 46 U.S. and Canadian hospitals. Patients were randomly assigned in a 1:1 ratio to receive spinal or general anesthesia. The primary outcome was a composite of death or an inability to walk approximately 10 ft (3 m) independently or with a walker or cane at 60 days after randomization. Secondary outcomes included death within 60 days, delirium, time to discharge, and ambulation at 60 days.
A total of 1600 patients were enrolled; 795 were assigned to receive spinal anesthesia and 805 to receive general anesthesia. The mean age was 78 years, and 67.0% of the patients were women. A total of 666 patients (83.8%) assigned to spinal anesthesia and 769 patients (95.5%) assigned to general anesthesia received their assigned anesthesia. Among patients in the modified intention-to-treat population for whom data were available, the composite primary outcome occurred in 132 of 712 patients (18.5%) in the spinal anesthesia group and 132 of 733 (18.0%) in the general anesthesia group (relative risk, 1.03; 95% confidence interval CI, 0.84 to 1.27; P = 0.83). An inability to walk independently at 60 days was reported in 104 of 684 patients (15.2%) and 101 of 702 patients (14.4%), respectively (relative risk, 1.06; 95% CI, 0.82 to 1.36), and death within 60 days occurred in 30 of 768 (3.9%) and 32 of 784 (4.1%), respectively (relative risk, 0.97; 95% CI, 0.59 to 1.57). Delirium occurred in 130 of 633 patients (20.5%) in the spinal anesthesia group and in 124 of 629 (19.7%) in the general anesthesia group (relative risk, 1.04; 95% CI, 0.84 to 1.30).
Spinal anesthesia for hip-fracture surgery in older adults was not superior to general anesthesia with respect to survival and recovery of ambulation at 60 days. The incidence of postoperative delirium was similar with the two types of anesthesia. (Funded by the Patient-Centered Outcomes Research Institute; REGAIN ClinicalTrials.gov number, NCT02507505.).
This study tests a model of creative role identity for a sample of Taiwanese employees. Results showed creative role identity was predicted by perceived coworker creativity expectations, self-views ...of creative behaviors, and high levels of exposure to U.S. culture. Creativity was highest when a strong creative role identity was paired with perceptions that the employing organization valued creative work. Implications for managers and future creativity research are discussed.
The structure, dynamics, and vibrational spectroscopy of dilute HOD, methanol, and ethanol in the 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide, emimNTf2, ionic liquid (IL) are ...investigated with molecular dynamics (MD) simulations. The structure of the ILs around the solutes is qualitatively similar, where the OD bond of the deuterated alcohols donates an interaction to an NTf2 anion and the emim cations interact with the oxygen atom of the OD group. The slowest time scale for the reorientational dynamics of the OD bond varied considerably for HOD, methanol, and ethanol (27, 71, and 87 ps, respectively). In contrast, the slowest time scales for spectral diffusion of the OD vibrational frequency were 11 ps for each of the three solutes, which indicates that the dynamics of the IL is relatively unchanged by the presence of the alcohols at dilute concentration. The theoretical results for the reorientational and spectral diffusion dynamics compare favorably with prior two-dimensional infrared (2D IR) spectroscopic measurements.
Practitioners are finding it increasingly difficult to develop effective roadmapping efforts for many new products and innovations. We argue that this difficulty stems from the fundamental ...differences between many of today's innovations and earlier ones. Many current innovations are: using technology differently; more heavily constrained; forcing new business models and increasingly being shaped by drivers. Current roadmapping techniques do not translate well to this new reality. Roadmapping efforts for these innovations are increasingly failing to meet their primary goal of including technology into the strategic process of firms, regions or industries.
We seek to address this concern by creating a new roadmapping technique, one we name Technology Landscaping. We build this technique by basing it upon the relevant sections and structures found in first and second generation roadmapping theories and practices. We then apply new theory and processes that are in alignment with the nature of these new products and innovations. We test our model through a case study of new pharmaceutical industry innovations. Finally, we present our new roadmapping technique.
Objective:
Online banking is becoming increasingly common among middle-aged and older adults, who may experience difficulties effectively navigating this sometimes complicated technology. This study ...examined age effects on a performance-based internet banking task and its association with neurocognitive, functional, and numerical abilities.
Method:
Thirty-five older adults (age 51-75) and 50 younger adults (age 18-32) completed an experimenter-controlled online banking measure in which they independently performed a series of naturalistic financial tasks (e.g., account transfers, bill paying). Participants also completed standardized tests of cognition, numeracy, and functional capacity.
Results:
Older adults were markedly slower and less accurate in completing the internet-based banking task, which was not confounded by other demographic, mood, or computer use factors. Higher scores on measures of neurocognition, numeracy, and financial functional capacity were both strongly associated with higher internet-based banking among older, but not younger adults.
Conclusions:
Findings suggest that older adults experience difficultly quickly and accurately navigating online banking platforms, which may be partly related to age-related declines in neurocognitive functions and basic financial capacity. Future studies might examine whether neurocognitive approaches to remediation and compensation can be used to improve online banking capacity in older adults.
Key Points
Question: What roles do neurocognition and financial functioning play in performance on a naturalistic online banking task among younger and older adults?
Finding: Older adults were slower and less accurate than younger adults at completing online banking tasks, performance on which was associated with neurocognitive, functional, and numerical abilities in the older adults.
Importance: Findings suggest that age-related declines in neurocognitive functions and basic financial skills may make it challenging for older adults to effectively manage their finances online.
Next Steps: Future research should examine the potential benefits of cognitive strategies in supporting the navigational and financial abilities of older adults during their handling of finances on the internet.
Objectives: Apathy is common in older adults and has been linked to adverse health outcomes. The current study examined whether apathy contributes to problems managing activities of daily living ...(ADLs) and lower quality of life (QoL) in older adults.
Method: Participants included 83 community-dwelling older adults. Apathy was assessed using a composite of the self and family-rating scales from the Frontal Systems Behavioral Scale (FrSBe). A knowledgeable informant completed the Activities of Daily Living Questionnaire (ADLQ), and participants completed the World Health Organization Quality of Life (WHOQol) scale.
Results: Nominal logistic regressions controlling for age, anxiety and depression symptoms, chronic medical conditions, and global cognition revealed that higher levels of apathy were significantly associated with a wide range of mild ADL problems. In parallel, a multiple linear regression indicated that greater apathy was significantly associated with lower QoL independent of ADL problems, anxious and depressive symptomology, chronic medical conditions, global cognition and age.
Discussion: Findings suggest that apathy confers an increased risk of problems in the independent management of daily activities and poorer well-being among community-dwelling older adults. Neurobehavioral and pharmacological interventions to improve apathy may have beneficial effects on the daily lives of older adults.
PDF
