México cuenta con la Norma Oficial Mexicana 025 de la Secretaría del Trabajo y Previsión Social del año 2008 cuyo objetivo es establecer los requerimientos de iluminación en las áreas de los centros ...de trabajo y con ello proveer un ambiente seguro y saludable en la realización de las tareas que desarrollen los trabajadores. En este sentido, la iluminación se puede medir con un instrumento llamado luxómetro, pero en ocasiones no se dispone de uno de manera regular en los centros de trabajo. En esta investigación se desarrolló una aplicación móvil para dispositivos Android que permite tomar mediciones de iluminación, como lo hace un luxómetro. Además, los resultados que ofrece esta aplicación indican si el nivel es adecuado según lo establecido en la mencionada norma. Se empleó la metodología de desarrollo Kanban y el entorno de desarrollo integrado (IDE) Android Studio con lenguajes de programación Java, Python (TensorFlow) y PHP. Para asegurar la calidad de los resultados se tomó una muestra de lecturas (n=21) obtenidas con la aplicación y de forma similar con un luxómetro comercial. Posteriormente, se comprobó su normalidad a través de la prueba Ryan-Joyner y se realizó una prueba t para muestras independientes (?=0.05). Los resultados confirmaron la normalidad de los datos y el no rechazo de la hipótesis de igualdad de medias en la prueba t de muestras independientes. Por lo tanto, los resultados de la muestra obtenida con la aplicación no tienen diferencia media significativa con los obtenidos de la muestra del luxómetro comercial.
Introducción: Los adolescentes transitan por una etapa de cambios biológicos, psicológicos y sociales que pudieran ser factores condicionantes en la adquisición de conductas nocivas como el uso y/o ...abuso de alcohol. Objetivo: Establecer la asociación entre autoestima y el consumo de alcohol de los adolescentes. Metodología: Estudio descriptivo correlacional llevado a cabo en 191 adolescentes de Educación Secundaria de Ciudad del Carmen Campeche, México. Se utilizó la Prueba de Identificación de Desórdenes por Uso de Alcohol (AUDIT) y la Escala de Autoestima de Rosenberg. Resultados: Predomina el tipo de consumo de dependiente (35.4%) seguido del sensato (34.1%), por sexo en los varones predomina un consumo dependiente (39.4%) y en las mujeres un consumo sensato (38.8%). Se estableció una relación negativa entre el autoestima y consumo de alcohol de acuerdo a la puntuación AUDIT (r= -.425, p=.042). Conclusión: La ingesta de bebidas alcohólicas representa un problema creciente de salud que pudiera ocasionar múltiples daños a la salud de los adolescentes, además de estar asociado a variables psicológicas como la autoestima, que juega un papel primordial en la adquisición o modificación de hábitos saludables o no, y por lo tanto constituye un factor protector ante el consumo de alcohol.
Immunogenic cell death is a cell death modality that stimulates the immune system to combat cancer cells. IMMUNEPOTENT CRP (ICRP) is a mixture of substances of low molecular weight obtained from ...bovine spleens that exhibits
cytotoxic activity on different tumor cell lines and modulates the immune response
. The aim of the present study was to determine whether the cytotoxic effect of ICRP and its combination with oxaliplatin (OXP) on murine melanoma B16F10 cells was due to immunogenic cell death. The cytotoxic assay was performed using flow cytometry to detect Annexin V and propidium iodide staining, and calreticulin (CRT) exposure. Adenosine triphosphate, heat shock protein (HSP) 70, HSP90 and high mobility group box 1 (HMGB1) release were identified using bioluminescence, western blot and ELISA assays, respectively. The present
study demonstrated that treatments with ICRP or OXP induced cell death in a time-dependent manner, but treatment with the combination of ICRP + OXP increased the cytotoxic effect following 24 h of treatment. CRT exposure and release of adenosine triphosphate (ATP), HSP70, HSP90 and HMGB1 were induced by treatment with ICRP, and the combination of ICRP + OXP increased the exposure and release of damage-associated molecular patterns (DAMPs), while OXP treatment only induced CRT exposure, ATP and HMGB1 release. The
experiments demonstrated that administration of tumor-derived DAMP-rich cell lysates derived from B16F10 cells treated with ICRP and the combination of ICRP + OXP prevented melanoma growth; however, OXP treatment did not. These results suggested that IMMUNEPOTENT CRP may be used as an agent to increase the ability of antitumor drugs to induce immunogenic cell death and prevent the growth of melanoma.
Objectives
The purpose of this study is to analyse the effect of a community participation programme based on the ecosystem model on the incidence of dengue in urban communities.
Methods
A randomized ...controlled field trial was conducted in the state of Colima, Mexico. The intervention consisted of a community participation programme focused on the ecosystem; simultaneously, the control groups were communities that only received the usual official prevention programs. The incidence of dengue was estimated in people of both groups due to the appearance of de novo IgM antibodies during the follow-up period.
Results
The incidence of dengue in the intervened group was 2.58%/month (
n
= 818) and in control group 2.26%/month (
n
= 994), with a risk ratio of 1.14 (95% CI 0.89–1.45) and a PAF of 0.06 (95% CI − 0.056 to 0.16). The
A. aegypti
larval density (Breteau Index) was reduced in the treated group.
Conclusions
The implementation of a community participation programme in the cities of Colima, Mexico, showed a slightly counterproductive effect on the incidence of dengue. This happened even with a reduction in the
A. aegypti
index.
: Descriptive sensory analysis combined with a chemical analysis, provided insight regarding sensory significance for a better understanding of berrycactus' flavor. This study was based on the ...volatile components derived from the gas chromatography‐olfactometry (GC‐O) analysis. Four different ripening stages were used for the experiments: unripe, red, transition, and over‐ripe. Besides red and transition stages were stored in sealed plastic bags for 7 d at 5 °C as an additional treatment in order to establish comparisons with fresh samples. GC‐O analysis was performed following OSME (time‐intensity) method. Moreover, chemical characterization was achieved through GC–MS analysis, each compound was tentatively identified by comparing its mass spectra with the spectra from the library NIST02, by its aroma notes and Kovats Index. The aroma descriptors found were: caramel, fruity, acetic acid, fresh, citrus, floral, and phenolics. Nine volatile compounds are among the most important in flavor of berrycactus: furfural, 5‐methyl‐2‐furancarboxaldehyde, 2(5H)‐furanone, 5‐acetoxymethyl‐2‐furaldehyde, 2‐cyclohexen‐1‐ol, octanoic acid ethyl ester, decanoic acid ethyl ester, octanoic acid, and phenylethyl alcohol. To better reflect the real responses of these compounds, the regression analysis of concentrations to ripening stages were performed. The 2,3‐dihydro‐3,5‐dihydroxy‐6‐methyl‐(4H)‐pyran‐4‐one was found in berrycactus, it has been reported in chemical profile of other berries as a product of heat‐induced reactions, however, this compound has no aroma activity. The data suggest that both furanones and esters contribute to the aroma of berrycactus. On the other hand, solid phase microextraction was found to be more useful in detecting esters and acids whereas solvent extraction was more effective in detecting furanones and ketones.
Practical Application: This information could contribute to setting up favorable processing conditions; in order to retain the best sensory characteristics of berrycactus along with functional properties that would enhance commercialization and exploitation of this fruit and to promote berrycactus cultivation programs.
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