The present article aims to analyze the representations and the role of symbolic forms of mythical-religious thought in the mediatization of sustainability. A main corpus of items, composed of the ...media information and news offer covered by the mainstream French media, and a secondary corpus, as important, related to Francophone scientific articles, was considered. The study, conducted on French media news referenced by the Google search engine between 2009 and 2018, highlights a production of secular meaning of sustainability through mythical-religious references, a growth in the spiritualization of media content of the journalistic offer on sustainability, and the hegemony of the media, the omnipotence of the mediatized thing producing “an effect of Church” by legitimizing a certain “truth” of the information.
Background Artificial intelligence (AI) has become a pivotal tool in advancing contemporary personalised medicine, with the goal of tailoring treatments to individual patient conditions. This has ...heightened the demand for access to diverse data from clinical practice and daily life for research, posing challenges due to the sensitive nature of medical information, including genetics and health conditions. Regulations like the Health Insurance Portability and Accountability Act (HIPAA) in the U.S. and the General Data Protection Regulation (GDPR) in Europe aim to strike a balance between data security, privacy, and the imperative for access. Results We present the Gemelli Generator - Real World Data (GEN-RWD) Sandbox, a modular multi-agent platform designed for distributed analytics in healthcare. Its primary objective is to empower external researchers to leverage hospital data while upholding privacy and ownership, obviating the need for direct data sharing. Docker compatibility adds an extra layer of flexibility, and scalability is assured through modular design, facilitating combinations of Proxy and Processor modules with various graphical interfaces. Security and reliability are reinforced through components like Identity and Access Management (IAM) agent, and a Blockchain-based notarisation module. Certification processes verify the identities of information senders and receivers. Conclusions The GEN-RWD Sandbox architecture achieves a good level of usability while ensuring a blend of flexibility, scalability, and security. Featuring a user-friendly graphical interface catering to diverse technical expertise, its external accessibility enables personnel outside the hospital to use the platform. Overall, the GEN-RWD Sandbox emerges as a comprehensive solution for healthcare distributed analytics, maintaining a delicate equilibrium between accessibility, scalability, and security. Keywords: GEN-RWD Sandbox, Privacy-preserving data sharing, Personalised medicine, Distributed analytics
New therapeutic approaches are needed for the management of the highly chemo- and radioresistant chondrosarcoma (CHS). In this work, we used polyethylene glycol-encapsulated iron oxide nanoparticles ...for the intracellular delivery of the chemotherapeutic doxorubicin (IONPDOX) to augment the cytotoxic effects of carbon ions in comparison to photon radiation therapy. The in vitro biological effects were investigated in SW1353 chondrosarcoma cells focusing on the following parameters: cell survival using clonogenic test, detection of micronuclei (MN) by cytokinesis blocked micronucleus assay and morphology together with spectral fingerprints of nuclei using enhanced dark-field microscopy (EDFM) assembled with a hyperspectral imaging (HI) module. The combination of IONPDOX with ion carbon or photon irradiation increased the lethal effects of irradiation alone in correlation with the induction of MN. Alterations in the hyperspectral images and spectral profiles of nuclei reflected the CHS cell biological modifications following the treatments, highlighting possible new spectroscopic markers of cancer therapy effects. These outcomes showed that the proposed combined treatment is promising in improving CHS radiotherapy.
This article outlines and discusses two aspects of the French mediatization of Tu ne tueras point (Hacksaw Ridge) film: the relationship between media, normative secularism and religion in the ...context of the hegemony of mediatization as ‘media and communication-centered’ phenomenon. Based on the content analysis and discursive strategies of the biographical war drama chronicles, the contribution points out less developed empirical aspects in France regarding the relation between religion and media: (a) the media discourse is dependent on a normative narrative of secularism, (b) the media discourse represents and expresses a confusion between the sacred, religion and faith, deliberately created and maintained by the journalists, and (c) the media discourse is based on a conception of violence with modern origins.
Chondrosarcoma is a malignant cartilaginous tumor that is particularly chemoresistant and radioresistant to X-rays. The first line of treatment is surgery, though this is almost impossible in some ...specific locations. Such resistances can be explained by the particular composition of the tumor, which develops within a dense cartilaginous matrix, producing a resistant area where the oxygen tension is very low. This microenvironment forces the cells to adapt and dedifferentiate into cancer stem cells, which are described to be more resistant to conventional treatments. One of the main avenues considered to treat this type of tumor is hadrontherapy, in particular for its ballistic properties but also its greater biological effectiveness against tumor cells. In this review, we describe the different forms of chondrosarcoma resistance and how hadrontherapy, combined with other treatments involving targeted inhibitors, could help to better treat high-grade chondrosarcoma.
Besides the direct effects of radiations, indirect effects are observed within the surrounding non-irradiated area; irradiated cells relay stress signals in this close proximity, inducing the ...so-called radiation-induced bystander effect. These signals received by neighboring unirradiated cells induce specific responses similar with those of direct irradiated cells. To understand the cellular response of bystander cells, we performed a 2D gel-based proteomic study of the chondrocytes receiving the conditioned medium of low-dose irradiated chondrosarcoma cells. The conditioned medium was directly analyzed by mass spectrometry in order to identify candidate bystander factors involved in the signal transmission. The proteomic analysis of the bystander chondrocytes highlighted 20 proteins spots that were significantly modified at low dose, implicating several cellular mechanisms, such as oxidative stress responses, cellular motility, and exosomes pathways. In addition, the secretomic analysis revealed that the abundance of 40 proteins in the conditioned medium of 0.1 Gy irradiated chondrosarcoma cells was significantly modified, as compared with the conditioned medium of non-irradiated cells. A large cluster of proteins involved in stress granules and several proteins involved in the cellular response to DNA damage stimuli were increased in the 0.1 Gy condition. Several of these candidates and cellular mechanisms were confirmed by functional analysis, such as 8-oxodG quantification, western blot, and wound-healing migration tests. Taken together, these results shed new lights on the complexity of the radiation-induced bystander effects and the large variety of the cellular and molecular mechanisms involved, including the identification of a new potential actor, namely the stress granules.
Addressing complex interactions within water, energy, and food (WEF) resources, innovative tools for in-depth analysis and decision-making are imperative. This study introduces chorematic focus maps ...(CFMs) as a groundbreaking method to visualize and tackle the WEF nexus’s complexities, focusing specifically on the Danube Delta Biosphere Reserve (DDBR). By merging geospatial analysis with on-site validation, this research reveals intricate interdependencies within the nexus and positions CFMs as an effective tool for stakeholders. This study adopts a methodological approach that focuses on identifying human activities and evaluating their impacts on the WEF nexus, with the goal of developing practical and grounded strategies for managing these essential resources. By testing this approach within the DDBR, the potential for wider application is demonstrated, offering a promising framework for addressing similar socio-environmental challenges across various regions. Future research directions include refining CFMs’ precision and practicality through extended fieldwork and stakeholder engagement, testing the framework’s adaptability across various locations and nexus dynamics. Additionally, incorporating cutting-edge technologies such as machine learning could provide deeper insights and reinforce CFMs’ role in decision support for the WEF nexus. Conclusively, this investigation into the WEF nexus through CFMs emphasizes the critical need for strategies that navigate the complexities of environmental management and resource optimization, marking CFMs as a significant tool for both decision-makers and researchers.
This article is a snapshot of the current attitudes manifested by the Romanian Orthodox seminarians towards interdenominational networking from the perspectives of individual interests, cultural ...representation, and institutional structure. Using the interdenominational networking as a social platform, the article considers the tension between rational choice and structuralism, whereby an Orthodox seminarian navigates between individual interests and institutional constrains; while also instrumentalizing cultural representation. For this purpose, a face-to-face survey was administered to 133 Protestant and Orthodox seminarians in Romania enrolled as fulltime students in the pastoral theology programmes at five theological seminaries. The contribution of this research lies in the fact that the data we collected and analysed serves as a social barometer revealing not only the restrained attitudes of the Romanian Orthodox seminarians towards interdenominational networking, but also their inability to bypass the deep-seated religious prejudice due to indoctrination and competition for credibility.
Through the lens of mediatization theory, this article questions the notion of the self-exposure of the writer as self-media to develop an approach to the author and artistic work that highlights how ...the logics of social media transform the author into an acthor. The analysis focuses on a corpus of posts made during the COVID‑19 pandemic by ten Romanian writers who used Facebook to varying degrees to promote their works in several literary genres. It examines the changing role of the digital writer and the emergence of a new acthorial figure in relation to a cultural landscape where new information and communication technologies have an increasingly significant impact on the authors’ own practices of promoting their artistic work. From a communications perspective, the article argues that mediatization provides an interpretive framework for thinking about personal media practices on a broad scale and for reflecting on the changes in acthorial modes of communication in terms of practice and usage.
The Chilia branch is the north branch of the Danube River at the Romania-Ukraine border in the Danube Delta; it is a complex system with economic and ecological values. The surface water quality is a ...major concern and monitoring programs have been developed at the national and international level. The objective of this study was to evaluate the water quality of the Chilia branch in different sampling points from the mouth to the discharge in the Black Sea. The assessment of water quality was done at the individual level taking into account the nutrient concentrations and the standard limits for good ecological status and at integrative levels, using CCME WQI. The longitudinal distribution of Chilia branch water quality was done using GIS method. A total of 106 water samples were collected between 2013 and 2019 from five sampling points. At the individual level, the Chilia branch has a good ecological status except for its levels of total nitrogen, due to the organic nitrogen contribution in 2015. In 90% of nutrient concentrations, low values predominate and high values are considered extreme; only in 10% do high values predominate and low values are considered extreme concentrations. In equal percentages, 50% of the nutrient concentrations have a high degree of heterogeneity and the other 50% of concentration values are very close to the average values, with a high degree of homogeneity. CCME WQI method indicated that 39.93% of surface waters from the Chilia branch had an excellent quality, 45.45% a good quality, and only 14.62% a fair quality.
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