In recent years, the complex treatment of schizophrenia has been extended by the neuroleptic large-dose therapy. Our investigations carried out so far, which reflect the experiences gained in several ...years with this form of treatment, include 30 schizophrenic patients admitted in an acute psychotic condition. They were treated for six days running with 40 to 120 (average 65) mg of Haloperidol daily. The results of our studies show that the large-dose therapy with Haloperidol as an initial phase of a combined pharmaco-therapy represents a safe, rapid and effective method.
Discussing two cases, the authors describe their opinion on the etiopathogenicity of the dermatozoic delusion. They point to the necessity of a multidimensional examination of the syndrome, to its ...relative incidence, and to the advantageous possibilities of a therapy.
Two case reports and data from literature on the subject are used by the authors to describe characteristics of pathogenetic importance of neuroleptic induced stupor (NIS). The origin of NIS is ...outlined briefly and some fundamental clinical and experimental facts are presented, all of which stress the importance of the acute blockade of postsynaptic DA-ergic receptors. Emphasis is placed on the significance of the possible relationship and similarity between NIS and catatonic stupor, and on the theoretical possibilities which this offers.
The authors studied the effectiveness of neuroleptic high-dosage therapy in comparison to the electroshock treatment in the acute phase of systematic and unsystematic schizophrenia in a total of 75 ...patients. The results obtained show that the neuroleptic high-dosage therapy exceeds the effectiveness of the electroshock treatment mainly in the group of unsystematic schizophrenia.
