To compare conventional sensitivity encoding turbo spin-echo (SENSE-TSE) with compressed sensing plus SENSE turbo spin-echo (CS-TSE) in lumbar vertebrae magnetic resonance imaging (MRI).
This ...retrospective study of lumbar vertebrae MRI included 600 patients; 300 patients received SENSE-TSE and 300 patients received CS-TSE. The SENSE acceleration factor was 1.4 for T1WI, 1.7 for T2WI, and 1.7 for PDWI. The CS total acceleration factor was 2.4, 3.6, 4.0, and 4.0 for T1WI, T2WI, PDWI sagittal, and T2WI transverse, respectively. The image quality of each MRI sequence was evaluated objectively by the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) and subjectively on a five-point scale. Two radiologists independently reviewed the MRI sequences of the 300 patients receiving CS-TSE, and their diagnostic consistency was evaluated. The degree of intervertebral foraminal stenosis and nerve root compression was assessed using the T1WI sagittal and T2WI transverse images.
The scan time was reduced from 7 min 28 s to 4 min 26 s with CS-TSE. The median score of nerve root image quality was 5 (p > 0.05). The diagnostic consistency using CS-TSE images between the two radiologists was high for diagnosing lumbar diseases (κ > 0.75) and for evaluating the degree of lumbar foraminal stenosis and nerve root compression (κ = 0.882). No differences between SENSE-TSE and CS-TSE were observed for sensitivity, specificity, positive predictive value, or negative predictive value.
CS-TSE has the potential for diagnosing lumbar vertebrae and disc disorders.
Background
Deuterium metabolic imaging (DMI) has emerged as a promising non-invasive technique for studying metabolism
in vivo
. This review aims to summarize the current developments and discuss the ...futures in DMI technique
in vivo
.
Methods
A systematic literature review was conducted based on the PRISMA 2020 statement by two authors. Specific technical details and potential applications of DMI
in vivo
were summarized, including strategies of deuterated metabolites detection, deuterium-labeled tracers and corresponding metabolic pathways
in vivo
, potential clinical applications, routes of tracer administration, quantitative evaluations of metabolisms, and spatial resolution.
Results
Of the 2,248 articles initially retrieved, 34 were finally included, highlighting 2 strategies for detecting deuterated metabolites: direct and indirect DMI. Various deuterated tracers (
e.g.
, 6,6′-
2
H2glucose, 2,2,2′-
2
H3acetate) were utilized in DMI to detect and quantify different metabolic pathways such as glycolysis, tricarboxylic acid cycle, and fatty acid oxidation. The quantifications (
e.g.
, lactate level, lactate/glutamine and glutamate ratio) hold promise for diagnosing malignancies and assessing early anti-tumor treatment responses. Tracers can be administered orally, intravenously, or intraperitoneally, either through bolus administration or continuous infusion. For metabolic quantification, both serial time point methods (including kinetic analysis and calculation of area under the curves) and single time point quantifications are viable. However, insufficient spatial resolution remains a major challenge in DMI (
e.g.
, 3.3-mL spatial resolution with 10-min acquisition at 3 T).
Conclusions
Enhancing spatial resolution can facilitate the clinical translation of DMI. Furthermore, optimizing tracer synthesis, administration protocols, and quantification methodologies will further enhance their clinical applicability.
Relevance statement
Deuterium metabolic imaging, a promising non-invasive technique, is systematically discussed in this review for its current progression, limitations, and future directions in studying
in vivo
energetic metabolism, displaying a relevant clinical potential.
Key points
• Deuterium metabolic imaging (DMI) shows promise for studying
in vivo
energetic metabolism.
• This review explores DMI’s current state, limits, and future research directions comprehensively.
• The clinical translation of DMI is mainly impeded by limitations in spatial resolution.
Graphical Abstract
We demonstrate the synthesis of SiGe-based three-dimensional (3D) porous nanostructures via a template-assisted method. When tested as electrode in lithium-ion batteries, it exhibits a reversible ...capacity as high as 1311 mAh g−1 after 45 cycles at a current density of 4 A g−1. Even at a super high current rate of 16 A g−1, the electrode can deliver a stable capacity of about 1047 mAh g−1. The great cycling performance and superior rate capability can be attributed to the good electrical contact, fast electron transport and good strain accommodation of the 3D nanostructure of the porous electrode.
► SiGe layer was deposited on a Cu 3D nanoporous current collector. ► The Cu–SiGe 3D electrodes show high performance as anode for Li-ion battery. ► High performance is attributed to the advantages of the electrodes' structure.
•Identification of patients with high risk for chronic ankle instability (CAI) is crucial for more effective and efficient treatment of acute lateral ankle sprain (LAS).•For patients who had at least ...1 positive clinical finding in the 10-meter walk test, the anterior drawer test, or the inversion tilt test, magnetic resonance imaging (MRI) scans were helpful in predicting CAI after first-episode LAS.•Age, body mass index, posterior talofibular injury, large talus bone marrow lesion, and Grade 2 tibiotalar joint effusion were 5 prognostic factors that MRI scanning used to predict CAI after first-episode LAS.
Chronic ankle instability (CAI) is a common sequela following an acute lateral ankle sprain (LAS). To treat an acute LAS more effectively and efficiently, it is important to identify patients at substantial risk for developing CAI. This study identifies magnetic resonance imaging (MRI) manifestations for predicting CAI development after a first episode of LAS and explores appropriate clinical indications for ordering MRI scans for these patients.
All patients with a first-episode LAS who received plain radiograph and MRI scanning within the first 2 weeks after LAS from December 1, 2017 to December 1, 2019 were identified. Data were collected using the Cumberland Ankle Instability Tool at final follow-up. Demographic and other related clinical variables, including age, sex, body mass index, and treatment were also recorded. Univariable and multivariable analyses were performed successively to identify risk factors for CAI after first-episode LAS.
A total 131 out of 362 patients with a mean follow-up of 3.0 ± 0.6 years (mean ± SD; 2.0–4.1 years) developed CAI after first-episode LAS. According to multivariable regression, development of CAI after first-episode LAS was associated with 5 prognostic factors: age (odds ratio (OR) = 0.96, 95% confidence interval (95%CI): 0.93–1.00, p = 0.032); body mass index (OR = 1.09, 95%CI: 1.02–1.17, p = 0.009); posterior talofibular ligament injury (OR = 2.17, 95%CI: 1.05–4.48, p = 0.035); large bone marrow lesion of the talus (OR = 2.69, 95%CI: 1.30–5.58, p = 0.008), and Grade 2 effusion of the tibiotalar joint (OR = 2.61, 95%CI: 1.39–4.89, p = 0.003). When patients had at least 1 positive clinical finding in the 10-m walk test, anterior drawer test, or inversion tilt test, they had 90.2% sensitivity and 77.4% specificity in terms of detecting at least 1 prognostic factor by MRI.
MRI scanning was valuable in predicting CAI after first-episode LAS for those patients with at least 1 positive clinical finding in the 10-m walk test, anterior drawer test, and inversion tilt test. Further prospective and large-scale studies are necessary for validation.
Display omitted
With the development of heteronuclear fluorine, sodium, phosphorus, and other probes and imaging technologies as well as the optimization of magnetic resonance imaging (MRI) equipment and sequences, ...multi-nuclear magnetic resonance (multi-NMR) has enabled localize molecular activities in vivo that are central to a variety of diseases, including cardiovascular disease, neurodegenerative pathologies, metabolic diseases, kidney, and tumor, to shift from the traditional morphological imaging to the molecular imaging, precision diagnosis, and treatment mode. However, due to the low natural abundance and low gyromagnetic ratios, the clinical application of multi-NMR has been hampered. Several techniques have been developed to amplify the NMR sensitivity such as the dynamic nuclear polarization, spin-exchange optical pumping, and brute-force polarization. Meanwhile, a wide range of nuclei can be hyperpolarized, such as
2
H,
3
He,
13
C,
15
N,
31
P, and
129
Xe. The signal can be increased and allows real-time observation of biological perfusion, metabolite transport, and metabolic reactions in vivo, overcoming the disadvantages of conventional magnetic resonance of low sensitivity. HP-NMR imaging of different nuclear substrates provides a unique opportunity and invention to map the metabolic changes in various organs without invasive procedures. This review aims to focus on the recent applications of multi-NMR technology not only in a range of preliminary animal experiments but also in various disease spectrum in human. Furthermore, we will discuss the future challenges and opportunities of this multi-NMR from a clinical perspective, in the hope of truly bridging the gap between cutting-edge molecular biology and clinical applications.
•SiGe porous nanorod arrays were synthesized via template-assisted method.•The SiGe porous nanorod arrays were used as anode materials of Li-ion batteries.•The SiGe porous nanorod arrays show better ...performance than planar electrode.•The porous structure and addition of Ge is responsible for the good performance.
We demonstrate the synthesis of SiGe porous nanorod arrays by using ZnO nanorod arrays as a sacrificial template. A seed-assisted method was employed to synthesize ZnO nanorod arrays which were coated by SiGe layer via a co-sputtering method. After the removal of ZnO nanorod, SiGe porous nanorod arrays were achieved. When used as an anode material of lithium-ion batteries, SiGe porous nanorod arrays showed enhanced performance compared to corresponding planar electrode and bare Si porous nanorod arrays. The good contact and adhesion of the porous nanorod arrays with the current collector, and the integration of Ge that can greatly improve the conductivity and lithium-ion diffusivity in SiGe layer, may be responsible for the enhanced performance.
Long recovery time, large scar, postoperative swelling and pain are possible side effects of open reduction internal fixation (ORIF) for tarsal navicular fractures. Early exercise instruction is made ...possible by the use of an intraoperative robot-assisted percutaneous invasive closed reduction internal fixation. The goal of the trial was to determine whether percutaneous screw internal fixation with robot assistance might be used to treat navicular fractures.
27 patients with navicular fractures had surgical treatment between June 2019 and December 2021. Of those, 20 instances were treated with ORIF, while 7 cases had robot-assisted percutaneous screw internal fixation. At the final follow-up, the American Orthopaedic Foot & Ankle Society (AOFAS) hindfoot score and the visual analogue scale (VAS) score were compared to determine outcomes and function.
Follow-up was obtained in all 27 patients after surgery, with a mean follow-up time of 21.81 months, ranging from 15 to 29 months . In the 7 instances of robot-assisted group, percutaneous guide wire insertion and screw placement only needed one attempt and the depth and position of the implant were both satisfactory. In the ORIF group, there were two patients who sustained cutaneous nerve injuries. The AOFAS score and the VAS score of the group receiving robot-assisted navigation percutaneous screw fixation were 92.25 ± 2.22 and 0.75 ± 0.25 respectively at the last follow-up, while 82.25 ± 7.15 and 0.50 ± 0.29 were the respective values for the ORIF group.
Intraoperative robot-assisted percutaneous closed reduction internal fixation for tarsal navicular fractures can accomplish exact localization of fracture site, reduce soft tissue damage and operative time. According to current view, this method offers fewer complications, a faster recovery after surgery, and more patient satisfaction.
To examine amide proton transfer-weighted (APTw) combined with diffusion weighed (DWI) and dynamic contrast enhanced (DCE) MRI for early prediction of pathological response to neoadjuvant ...chemotherapy in invasive breast cancer.
In this prospective study, 50 female breast cancer patients (49.58 ± 10.62 years old) administered neoadjuvant chemotherapy (NAC) were enrolled with MRI carried out both before NAC (T0) and at the end of the second cycle of NAC (T1). The patients were divided into 2 groups based on tumor response according to the Miller-Payne Grading (MPG) system. Group 1 included patients with a greater degree of decrease in major histologic responder (MHR, Miller-Payne G4-5), while group 2 included non-MHR cases (Miller-Payne G1-3). Traditional imaging protocols (T1 weighted, T2 weighted, diffusion weighted, and DCE-MRI) and APTw imaging were scanned for each subject before and after treatment. APTw value (APTw0 and APTw1), Dmax (maximum diameter, Dmax0 and Dmax1), V (3D tumor volume, V0 and V1), and ADC (apparent diffusion coefficient, ADC0 and ADC1) before and after treatment, as well as changes between the two times points (ΔAPT, ΔDmax, ΔV, ΔADC) for breast tumors were compared between the two groups.
APT0 and APT1 values significantly differed between the two groups (
= 0.034 and 0.01). ΔAPTw values were significantly lower in non-MHR tumors compared with MHR tumors (
= 0.015). ΔDmax values were significantly higher in MHR tumors compared with non-MHR tumors (
= 0.005). ADC0 and ADC1 values were significantly higher in MHR tumors than in non-MHR tumors (
= 0.038 and 0.035). AUC (Dmax+DWI + APTw) = AUC (Dmax+APTw) > AUC (APTw) > AUC (Dmax+DWI) > AUC (Dmax).
APTw imaging along with change of tumor size showed a significant potential in early prediction of MHR for NAC treatment in breast cancer, which might allow timely regimen refinement before definitive surgical treatment.
•Nanostructured SnCo/Cu electrodes have been successfully fabricated.•A simple electrodeposition approach was employed.•The Cu arrays offer large surface area and improve electronic/ionic ...conductivity.•The electrodes show improved performance as anode for Li-ion batteries.•The improved performance was attributed to the nanostructured current collectors.
In this article, we report a two-step electrodeposition method for the synthesis of Cu/SnCo core–shell rod-shaped arrays as anodes of lithium-ion batteries. Firstly, the arrayed Cu nanorods with diameters of 200nm were fabricated on a Cu foil through an electrodeposition method with alumina oxide membrane (AAO) as the template. Secondly, the SnCo alloy shells were subsequently electrodeposited on the surface of the rod-shaped Cu arrays to form the hybrid nanostructures. These hybrid electrodes delivered the enhanced cyclic performance and high rate capability serving as the anode materials for lithium-ion batteries. The improved electrochemical performance might be attributed to the large surface-to-volume area, sufficient buffering space, and high electronic conductivity associated with these 3-dimensional (3D) nanostructures.
Nowadays, the geographical origin of camellia oil (extra virgin) can be confirmed only by chemical analysis and documental traceability. This preliminary methodological study inquires the efficacy of ...chemometric analysis and gas chromatography coupled to an electronic nose to provide a rapid tool for the discrimination of camellia oil from different geographical origins. This method is appropriate for serving to support or corroborate geographical origin of camellia oil (extra virgin) based on its fingerprint of volatile profile, which is developed by using discriminant analysis and multivariate ordination technique (partial least squares discriminant analysis and principal components analysis). The results demonstrate that chemometrics combined with the electronic nose technique can be applied for fingerprinting to establish the authenticity of camellia oil (extra virgin) to prevent both quality and prestige loss of this product.
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