Transition metal selenides have been attracting significant attention owing to their high conductivity and theoretical capacity. In this article, the N‐doped carbon (NDC)‐coated Ni1.8Co1.2Se4 ...nanoparticles encapsulated in NDC nanoboxes are prepared from the bi‐metal organic framework (Ni3Co(CN)62·6H2O, Ni‐Co BMOF) after the selenization reaction and carbon coating. When used as an anode material for sodium‐ion batteries, the prepared anode material delivers excellent rate performance (211 and 153 mA h g−1 at ultrahigh current densities of 30 and 50 A g−1, respectively) and good cycling performance (379.3 mA h g−1 at 0.5 A g−1 after 100 cycles). More importantly, it also exhibits superior sodium‐ion full cell (SIFC) performance when coupled with a high‐voltage Na3V2(PO4)2O2F cathode recently self‐made by the authors. The fabricated SIFC gives an energy density up to 227 W h kg−1 and the capacity retention of above 97.6% even after 60 cycles at 0.4 A g−1 in a voltage range of 1.2–4.3 V at 25 °C. Moreover, the low‐temperature (from 25 to −25 °C) Na‐storage performance of the fabricated SIFC is also studied.
An advanced anode material with outstanding high‐rate and low‐temperature properties is developed for sodium‐ion half/full batteries. In it, there exists a 3D conductive network composed of N‐doped dual carbon (NDDC) and abundant void spaces between NDDC and Ni1.8Co1.2Se4 nanoparticles, acting as not only a highway to achieve fast charge transfer but also an effective protector for active Ni1.8Co1.2Se4 material.
Aims
A meta‐analysis was conducted of the prevalence rates of compassion satisfaction, compassion fatigue and burnout to identify the factors influencing these rates.
Background
The extents of ...compassion fatigue and burnout adversely affect nursing efficiency. However, the reported prevalence rates vary considerably.
Methods
Data were acquired from electronic databases. Random effects meta‐analyses were performed to obtain pooled estimates of the prevalence rates of compassion satisfaction, compassion fatigue and burnout and their respective instrumental scores. Meta‐regression analyses were performed to identify factors influencing these rates.
Results
Data from 21 studies were used for the meta‐analysis. The prevalence rates of compassion satisfaction, compassion fatigue and burnout were 47.55%, 52.55% and 51.98%, respectively. The possession of Bachelor's or Master's degrees by the nurses was significantly inversely associated with the percent prevalence of compassion fatigue (coefficient: −1.187) and burnout (coefficient: −0.810). The compassion fatigue score was also significantly inversely associated with nursing status as registered or licensed practical nurse (coefficient: −0.135).
Conclusion
In nursing, the prevalence rates of compassion fatigue and burnout are high. Better education and training may have a moderating effect on compassion fatigue and burnout and could improve the quality of life of nurses.
•Enzymatic hydrolysis disrupted the α-helices of tree peony seed protein.•Alcalase had the strong hydrolytic ability for tree peony seed protein.•Alcalase hydrolysate had well physicochemical ...properties.•Alcalase hydrolysate exhibited superior antioxidant ability to TPSP.
The physicochemical and antioxidant properties of tree peony seed protein (TPSP) hydrolysates by Alcalase, Neutrase, Papain, Protamex, and Flavourzyme were investigated in this study. The physicochemical properties were characterized by SDS-PAGE, particle size distribution, fourier transform infrared and fluorescence spectroscopy etc. The antioxidant activities were determined by DPPH radical, ABTS radical, Fe2+ chelating, and reducing power. The results showed five proteases produced hydrolysates with a significantly reduced average particle size, α-helices, and surface hydrophobicity compared to TPSP. Alcalase and Neutrase hydrolysis enhanced the nutritional value of the hydrolysates. Alcalase hydrolysates possessed the highest degree of hydrolysis (27.97%) and lowest molecular weight (<13 kDa) with average particle size (231.33 nm). Alcalase hydrolysate displayed the highest radical scavenging (DPPH IC50 = 0.18 mg/mL, ABTS IC50 = 1.57 mg/mL), Fe2+ chelating activity (IC50 = 0.99 mg/mL), and reducing power (0.594). These results provide the fundamentals for TPSP hydrolysates as antioxidants to be employed in food industry or pharmaceutical industry.
Hard carbon is regarded as a promising anode material for sodium‐ion batteries (SIBs). However, it usually suffers from the issues of low initial Coulombic efficiency (ICE) and poor rate performance, ...severely hindering its practical application. Herein, a flexible, self‐supporting, and scalable hard carbon paper (HCP) derived from scalable and renewable tissue is rationally designed and prepared as practical additive‐free anode for room/low‐temperature SIBs with high ICE. In ether electrolyte, such HCP achieves an ICE of up to 91.2% with superior high‐rate capability, ultralong cycle life (e.g., 93% capacity retention over 1000 cycles at 200 mA g−1) and outstanding low‐temperature performance. Working mechanism analyses reveal that the plateau region is the rate‐determining step for HCP with a lower electrochemical reaction kinetics, which can be significantly improved in ether electrolyte.
A self‐supporting, flexible, additive‐free and scalable hard carbon paper (HCP) derived from tissue is rationally developed, and it achieves outstanding Na‐storage properties in terms of high initial Coulombic efficiency (91.2%), superior high‐rate capability, ultralong cyclic stability, as well as outstanding low‐T performance in ether electrolyte. More significantly, the Na‐storage and capacity attenuation mechanism of the HCP anode is revealed.
Long noncoding RNAs (lncRNAs) play nonnegligible roles in the epigenetic regulation of cancer cells. This study aimed to identify a specific lncRNA that promotes the colorectal cancer (CRC) ...progression and could be a potential therapeutic target.
We screened highly expressed lncRNAs in human CRC samples compared with their matched adjacent normal tissues. The proteins that interact with LINRIS (Long Intergenic Noncoding RNA for IGF2BP2 Stability) were confirmed by RNA pull-down and RNA immunoprecipitation (RIP) assays. The proliferation and metabolic alteration of CRC cells with LINRIS inhibited were tested in vitro and in vivo.
LINRIS was upregulated in CRC tissues from patients with poor overall survival (OS), and LINRIS inhibition led to the impaired CRC cell line growth. Moreover, knockdown of LINRIS resulted in a decreased level of insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2), a newly found N
-methyladenosine (m
A) 'reader'. LINRIS blocked K139 ubiquitination of IGF2BP2, maintaining its stability. This process prevented the degradation of IGF2BP2 through the autophagy-lysosome pathway (ALP). Therefore, knockdown of LINRIS attenuated the downstream effects of IGF2BP2, especially MYC-mediated glycolysis in CRC cells. In addition, the transcription of LINRIS could be inhibited by GATA3 in CRC cells. In vivo experiments showed that the inhibition of LINRIS suppressed the proliferation of tumors in orthotopic models and in patient-derived xenograft (PDX) models.
LINRIS is an independent prognostic biomarker for CRC. The LINRIS-IGF2BP2-MYC axis promotes the progression of CRC and is a promising therapeutic target.
Long-term operational stability is the foremost issue delaying the commercialization of perovskite solar cells (PSCs). Here we demonstrate an in-situ cross-linking strategy for operationally stable ...inverted MAPbI
PSCs through the incorporation of a cross-linkable organic small molecule additive trimethylolpropane triacrylate (TMTA) into perovskite films. TMTA can chemically anchor to grain boundaries and then in-situ cross-link to a robust continuous network polymer after thermal treatment, thus enhancing the thermal, water-resisting and light-resisting properties of organic/perovskite films. As a result, the cross-linked PSCs exhibit 590-fold improvement in operational stability, retaining nearly 80% of their initial efficiency after continuous power output for 400 h at maximum power point under full-sun AM 1.5 G illumination of Xenon lamp without any UV-filter. In addition, under moisture or thermal (85 °C) conditions, cross-linked TMTA-based PSCs also show excellent stability with over 90% of their initial or post burn-in efficiency after aging for over 1000 h.
The Urban heat island (UHI) effect is an increasingly serious problem in urban areas. Information on the driving forces of intra-urban temperature variation is crucial for ameliorating the urban ...thermal environment. Although prior studies have suggested that urban morphology (e.g., landscape pattern, land-use type) can significantly affect land surface temperature (LST), few studies have explored the comprehensive effect of 2D and 3D urban morphology on LST in different urban functional zones (UFZs), especially at a fine scale. Therefore, in this research, we investigated the relationship between 2D/3D urban morphology and summer daytime LST in Wuhan, a representative megacity in Central China, which is known for its extremely hot weather in summer, by adopting high-resolution remote sensing data and geographical information data. The “urban morphology” in this study consists of 2D urban morphological parameters, 3D urban morphological parameters, and UFZs. Our results show that: (1) The LST is significantly related to 2D and 3D urban morphological parameters, and the scattered distribution of buildings with high rise can facilitate the mitigation of LST. Although sky view factor (SVF) is an important measure of 3D urban geometry, its influence on LST is complicated and context-dependent. (2) Trees are the most influential factor in reducing LST, and the cooling efficiency mainly depends on their proportions. The fragmented and irregular distribution of grass/shrubs also plays a significant role in alleviating LST. (3) With respect to UFZs, the residential zone is the largest heat source, whereas the highest LST appears in commercial and industrial zones. (4) Results of the multivariate regression and variation partitioning indicate that the relative importance of 2D and 3D urban morphological parameters on LST varies among different UFZs and 2D morphology outperforms 3D morphology in LST modulation. The results are generally consistent in spring, summer and autumn. These findings can provide insights for urban planners and designers on how to mitigate the surface UHI (SUHI) effect via rational landscape design and urban management during summer daytime.
Cardiac surgery-associated acute kidney injury (CSA-AKI) is the most common clinically important complication in adult patients undergoing open heart surgery, and is associated with increased ...mortality and morbidity. In patients in intensive care units, CSA-AKI is the second most common type of AKI after septic AKI. In this Review, we explore the definition of CSA-AKI, discuss its epidemiology and identify its risk factors. We discuss current theories of the pathophysiology of CSA-AKI and describe its clinical course. Furthermore, we introduce diagnostic tools with particular reference to novel biomarkers of AKI and their potential utility; we analyse currently applied interventions aimed at attenuating AKI in patients undergoing cardiac surgery; and describe evidence from randomized controlled trials aimed at preventing or treating CSA-AKI. Finally, we explore issues in the use of renal replacement therapy, its timing, its intensity and its preferred modalities in patients with CSA-AKI, and we discuss the prognosis of CSA-AKI in terms of patient survival and kidney recovery.
Autophagy plays a crucial role in maintaining cellular homeostasis, and is closely related to the occurrence of variety of human diseases. It is known that autophagy occurs in response to various ...environmental stresses such as nutrient deficiency, growth factor deficiency, and hypoxia. Induced autophagy eliminates the damage caused by these stresses and returns to normal levels when the stresses are relieved. To comprehend the induction of autophagy under various stress conditions and the effects of autophagy on the life processes of cells, it is necessary to understand how autophagy is regulated. Many studies have shown that a number of signal transduction pathways are involved in the regulation of autophagy. Among these pathways, some pathways converge at the target of rapamycin (TOR), a highly conserved kinase important for autophagy regulation. This review will focus on the role of TOR signaling pathway in the regulation of autophagy.