A simple fluorescence turn-on sensor has been designed for the highly sensitive detection of glycoproteins on the basis of boronic acid functional polymer capped Mn-doped ZnS quantum dots ...(QDs@MPS@AAPBA). In the absence of glycoproteins, the fluorescence emission intensity of the QDs@MPS@AAPBA was relatively weaker due to the effective electronic transfer from the QDs to the boron moieties on its surface. While the glycoproteins were introduced into the system, an obvious fluorescence enhancement was observed. It was attributed to the boron moieties covalent binding glycans of the glycoproteins resulting in the electronic transfer process being inhibited. Under the optimal conditions, this fluorescent probe not only could be applied in a wide pH range of 5.0–9.0, but also the binding constants and detection limits of the QDs@MPS@AAPBA for horseradish peroxidase (HRP) and transferrin (TRF) were up to 7.23 × 106 M−1, 1.53 × 107 M−1 and 1.44 × 10−10 M, 3.36 × 10−10 M, respectively. Finally, this proposed method has also been utilized for the TRF determination in serum without any complicated pretreatment and the recovery was in the range of 95.7%–103.0%. As a result, it is promising for application on the glycoproteins detection in complex biological samples.
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•The first bullet point can be changed into: A fluorescence turn-on sensor for the sensitive detection of glycoproteins.•The limit of detection of the selected glycoproteins was lower than 0.1 nM.•The sensor could be applied in a wide pH range of 5.0–9.0.•High selectivity and anti-interference ability in TRF detection in serum.
An improved analytical model is presented for the design of nth-order cascaded Raman fiber lasers (CRFLs) by considering the variation of Raman fiber effective core area with Stokes wavelength. Using ...this model, we determine the approximate optimal Raman fiber length and output-coupler (OC) reflectivity which make pump-to-Stokes conversion efficiency maximum. The output performance for a fifth-order Ge-doped CRFL calculated by our model is compared with the published experimental data, and good agreements between them have been found. Our calculated results show that losses, including gray losses of fiber Bragg gratings and splicing losses of fibers, have a significant effect on CRFLs characteristics, and the conversion efficiency is insensitive to the variation of Raman fiber length or reflectivity of OC near the optimal value.
An efficient and selective glycoproteins enrichment platform is essential to glycoprotein biomarkers in early clinic diagnostics. In this work, the poly (ethylene glycol) methyl ether methacrylate ...(PEGMA) and 4-vinylphenylboronic acid (VPBA) copolymer brushes grafted magnetic carbon nanotubes composite MCNTs@p (PEGMA-co-VPBA) was prepared by surface-initiated atom transfer polymerization and applied for the selective enrichment of glycoproteins from the complex biological samples. The as-prepared MCNTs@p (PEGMA-co-VPBA) nanocomposite was characterized by Fourier transform-infrared spectroscopy (FTIR), transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and vibrating sample magnetometry (VSM). The MCNTs@p (PEGMA-co-VPBA) can recognize and bind specifically for glycoproteins via strong boronate affinity and excellent hydrophilicity and shows a really low non-specificity adsorption capability for non-glycoproteins. The adsorption capacity of MCNTs@p (PEGMA-co-VPBA) towards glycoproteins transferrin (Trf), horseradish peroxidase (HRP), and non-glycoproteins cytochrome c (Cyt C), lysozyme (Lyz) is 253.3 mg g−1, 51.1 mg g−1, 13.9 mg g−1 and 14.5 mg g−1, respectively. Furthermore, MCNTs@p (PEGMA-co-VPBA) can be applied to extract glycoproteins directly from egg white samples. These results demonstrated that MCNTs@p (PEGMA-co-VPBA) could be a potential affinity adsorbent in glycoprotein enrichment.
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•Poly (PEGMA-co-VPBA) copolymer brushes was grafted onto magnetic carbon nanotubes via SI-ATRP.•MCNTs@p (PEGMA-co-VPBA) showed the high hydrophilicity and good magnetic responsibility.•MCNTs@p (PEGMA-co-VPBA) exhibited the high binding capacity and selectivity towards glycoproteins.•MCNTs@p (PEGMA-co-VPBA) showed the good reusability as protein adsorbent.•MCNTs@p (PEGMA-co-VPBA) was applied for enrichment of glycoproteins from the complex biological samples.
Abstract
Water glass and silica-alumina sol were used as adhesives, uniformly mixed with silicon carbide powder. The effects of binder, binder concentration, sintering temperature, and sintering ...process on the granularity reconstruction of SiC powders were studied in detail. The results show that when water glass is used as the binding agent, vacuum sintering can effectively inhibit the oxidation of silicon carbide, and suitable granulation and sintering samples are obtained at a concentration of 5%. When silica-aluminum sol is used as the binding agent, it is discovered that the increase in engagement can effectively increase the particle size, and the best effect is achieved at a concentration of 10%. Both systems of binding agents can successfully bind silicon carbide micronized powder, enlarge silicon carbide particles, and accomplish the goal of Granularity reconstruction.
A novel numerical method is presented for the calculations of the coupled propagation equations in multi-wavelength Raman fiber lasers. By taking the advantages of genetic algorithm and shooting ...method, only a few of the best individuals at each generation are chosen to implement several shootings in order to accelerate theirs converging. The output characteristics of an all-fiber three-wavelength Raman fiber laser have been analyzed based on the proposed algorithm. Results show that the total output power linearly depends on the pump power with a slope efficiency of ∼51%. For the three output Stokes, the slope efficiencies of the longer wavelengths are larger than that of the shorter ones because the optical energy at the Stokes with shorter wavelengths allows for a transfer of optical power to the longer Stokes via stimulated Raman scattering. We also find that the total output power degrades by less than 10% by adjusting the output-coupler reflectivity and is insensitive to the variation of the Raman fiber length over a large range.
Plastics are versatile materials, offering lightweight, durable, and affordable solutions across various industries. However, their non‐degradable nature poses challenges by end of their life. This ...study presented an innovative carbonyl extraction method to utilize waste poly(bisphenol A carbonate) (PC) as reaction precursor to synthesis of activated furan as precursor for photoswitchable Stenhouse adducts. This innovative chemical strategy not only generated N,N’‐functionalized barbiturates but also provided an eco‐friendly and cost‐effective alternative to traditional synthesis methods. The method presented hereby not only promotes sustainability by repurposing waste polycarbonate as carbonyl equivalent under green conditions but also yielded reusable bisphenol A (BPA). Furthermore, the derived activated furans exhibited their functionality by forming colored donor‐acceptor Stenhouse adducts (DASAs) on aminated polymer surfaces. This work demonstrated a transition from a linear plastics economy toward a circular one, highlighting the potential of plastic waste as a resource for creating materials with improved properties.
This work presents a sustainable approach to extract carbonyl from waste poly(bisphenol A carbonate), facilitating eco‐friendly and cost‐effective synthesis of activated furans, essential for photoswitchable Stenhouse adducts. This approach not only repurposes waste polycarbonate but also generates reusable bisphenol A, endorsing circular economy principles and showcasing plastic waste′s potential in enhancing material properties, notably visible light‐induced isomerization.
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•The metal-support-interaction (MSI) between Pt and rutile TiO2 can be modulated by a mild photochemical strategy.•The Pt/TiO2 catalyst with moderate MSI has the best performance in ...catalytic oxidation of HCHO.•The promoted activity is much higher than that of most reported anatase and P25-based Pt/TiO2 catalysts.•The balanced electronic structure and spatial structure favor the activation of oxygen species.
The metal-support-interaction (MSI) has been attracting close attention for HCHO oxidation due to its specific electronic and structural effects. Here, we report a mild photochemical strategy for the modulation of the MSI between Pt and rutile TiO2. By increasing the irradiation intensity, more electrons were enriched on Pt and the contact between Pt and TiO2 became stronger, and even induce the encapsulation of Pt nanoparticles by TiO2. The apparent activation energies were 45.4 and 38.8 kJ/mol over the samples with weaker (P40) or stronger (P500) MSI, while decreased to 9.1 kJ/mol on the sample (P120) with moderate MSI. The promoted activity was much higher than that of most reported anatase and P25-based Pt/TiO2 catalysts. The balanced electronic structure and spatial structure favor the activation of oxygen species, thus promoting both the conversion of dioxymethylene to HCOO– species and the following decomposition of HCOO–.
The aim of this study was to analyze the trends and epidemiological characteristics of scarlet fever in Zhejiang Province in 2004-2018, intending to provide a basis for targeted prevention and ...control of this disease.
We collated the epidemiological data for cases of scarlet fever from the China Information System for Disease Control and Prevention (CISDCP) in Zhejiang province between 1 January 2004 and 31 December 2018. Descriptive statistical analysis was used to analyze epidemiological characteristics of scarlet fever, whereas the Getis-Ord Gi* statistic was used to determine the hotspot incidence of scarlet fever.
In 2004-2018, a total of 22,194 cases of scarlet fever were reported in Zhejiang Province, with no death reports. The annual average of scarlet fever incidence was 2.82/100,000 (range,1.12 to 6.34/100,000). The male incidence was higher than that among female (χ
= 999.834,
< 0.05), and a majority of the cases (86.42%) occurred in children aged 3-9 years. Each year, the incidence of scarlet fever in Zhejiang Province appeared two seasonal peaks: the first peak occurred from March to June (the constituent ratio was 49.06%), the second peak was lower than the first one during November and the following January (the constituent ratio was 28.67%). The two peaks were almost in accordance with the school spring semester and autumn-winter semester, respectively. The incidence in the northern regions of the province was generally higher than that in the southern regions. High-value clusters were detected in the central and northern regions, while low-value clusters occurred in the southern regions via the Getis-Ord Gi* statistical analysis.
The prevalence of scarlet fever in Zhejiang Province showed a marked seasonality variation and mainly clustered in the central and northern regions in 2004-2018. Children under 15 years of age were most susceptible to scarlet fever. Kindergartens and primary schools should be the focus of prevention and control, and targeted strategies and measures should be taken to reduce the incidence.
•Uniform alloyed Au-Pt nanoparticles with 2–3 nm were loaded on TiO2 via photodeposition.•The turnover frequency of Au-Pt/TiO2 is 3.4 times of that of Pt/TiO2.•Au-Pt alloy structure is beneficial for ...the adsorption and dissociation of oxygen.•Au-Pt alloy promotes the transformation of dioxymethylene species to formate species.
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Catalytic oxidation has been considered as one of the most promising strategies for the removal of indoor HCHO which causes multiple health problems. Alloyed Au-Pt showed potential for catalytic oxidation reactions, but the reports on HCHO oxidation are limited. In addition,understanding on the catalytic mechanism is lacking. In this work, a sodium citrate assistant photodeposition process was developed to fabricate highly dispersed dual Au-Pt alloy with 2–3 nm on the surface of TiO2. The turnover frequency of Au-Pt/TiO2 (68.6 h-1) is much higher than that of Pt/TiO2 (19.9 h-1). This enhancement was also confirmed on different TiO2 supports and with different Pt loading. Based on the experimental and density functional theory calculations, it was found that the alloyed Au-Pt has more metallic Pt and is beneficial for the adsorption and dissociation of oxygen. Therefore, the rapid conversion of dioxymethylene species to formate species, with reduced reaction barrier, promotes the performance in catalytic oxidation of HCHO.
Zhejiang Province is one of the five provinces in China that had the highest incidence of novel coronavirus disease (COVID-19). Zhejiang, ranked fourth highest in COVID-19 incidence, is located in ...the Yangtze River Delta region of southeast China. This study was undertaken to identify the space-time characteristics of COVID-19 in Zhejiang. Data on COVID-19 cases in Zhejiang Province from January to July 2020 were obtained from this network system. Individual information on cases and deaths was imported, and surveillance information, including demographic characteristics and geographic and temporal distributions, was computed by the system. The Knox test was used to identify possible space-time interactions to test whether cases that are close in distance were also close in time. Network analysis was performed to determine the relationship among the cases in a transmission community and to try to identify the key nodes. In total, 1475 COVID-19 cases and 1 fatal case were reported from January to July 2020 in Zhejiang Province, China. Most of the cases occurred before February 15.sup.th, which accounted for 90.10%. The imported cases increased and became the main risk in Zhejiang Province after February 2020. The risk areas showed strong heterogeneity according to the Knox test. The areas at short distances within 1 kilometer and at brief periods within 5 days presented relatively high risk. The numbers of subcommunities for the four clusters were 12, 9, 6 and 4. There was obvious heterogeneity in the modularity of subcommunities. The maximum values of the node centrality for the four clusters were 2.9474, 4.3706, 4.1080 and 2.7500. COVID-19 was brought under control over a short period in Zhejiang Province. Imported infections from outside of mainland China then became a new challenge. The effects of spatiotemporal interaction exhibited interval heterogeneity. The characteristics of transmission showed short range and short term risks. The importance to the cluster of each case was detected, and the key patients were identified. It is suggested that we should focus on key patients in complex conditions and in situations with limited control resources.
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