To achieve the electrochemical nitrogen reduction reaction (NRR) for efficient and sustainable NH3 production, catalysts should exhibit high selectivity and activity with optimal adsorption energy. ...Herein we developed a three‐dimensional (3D) amorphous BiNi alloy toward a significantly enhanced NRR compared with its crystalline and metal counterparts. Ni alloying enables the chemisorption of nitrogen and the lower free‐energy change for the *NNH formation, and the 3D alloy electrocatalyst exhibits high catalytic activity for NH3 production with a yield rate of 17.5 μg h−1 mgcat−1 and Faradaic efficiency of 13.8 %. The enhanced electron transfer and increased electrochemical surface area were revealed in the interconnected porous scaffold, affording it sufficiently efficient and stable activity for potential practical applications. This work offers new insights into optimizing the adsorption energy of reactants and intermediates combined with tuning the crystallinity of NRR electrocatalysts.
A 3D amorphous BiNi alloy gives a significantly enhanced electrocatalytic nitrogen fixation. Ni substitution in Bi enables the chemisorption of nitrogen and a lower ΔG for *NNH formation. Enhanced electron transfer and increased electrochemical surface area in the interconnected porous scaffold allow its efficient and stable activity for potential practical applications.
The mechanisms underlying specification of neuronal subtypes within the human nervous system are largely unknown. The blue (S), green (M), and red (L) cones of the retina enable high-acuity daytime ...and color vision. To determine the mechanism that controls S versus L/M fates, we studied the differentiation of human retinal organoids. Organoids and retinas have similar distributions, expression profiles, and morphologies of cone subtypes. S cones are specified first, followed by L/M cones, and thyroid hormone signaling controls this temporal switch. Dynamic expression of thyroid hormone-degrading and -activating proteins within the retina ensures low signaling early to specify S cones and high signaling late to produce L/M cones. This work establishes organoids as a model for determining mechanisms of human development with promising utility for therapeutics and vision repair.
The filamentous bacteriophage fd bind a cell target with exquisite specificity through its few copies of display peptides, whereas nanoparticles functionalized with hundreds to thousands of ...synthetically generated phage display peptides exhibit variable and often-weak target binding. We hypothesise that some phage peptides in a hierarchical structure rather than in monomeric form recognise and bind their target. Here we show hierarchial forms of a brain-specific phage-derived peptide (herein as NanoLigand Carriers, NLCs) target cerebral endothelial cells through transferrin receptor and the receptor for advanced glycation-end products, cross the blood-brain-barrier and reach neurons and microglial cells. Through intravenous delivery of NLC-β-secretase 1 (BACE1) siRNA complexes we show effective BACE1 down-regulation in the brain without toxicity and inflammation. Therefore, NLCs act as safe multifunctional nanocarriers, overcome efficacy and specificity limitations in active targeting with nanoparticles bearing phage display peptides or cell-penetrating peptides and expand the receptor repertoire of the display peptide.
The occurrence and removal mechanisms of bisphenol A (BPA) and its analogues in municipal WWTPs were critically reviewed in this article. BPA appeared to be the dominant bisphenol, and the removal ...efficiency of bisphenols was in the order of bisphenol AP>bisphenol P>bisphenol F>bisphenol Z>bisphenol C>bisphenol S>bisphenol B>BPA>bisphenol E>bisphenol AF. It was also found that BPA removal showed linear relationships to those of its analogues, which have been proven by BPA vs BPS or BPF. BPA removal performances in different treatment processes ranked from low to high are primary treatment, lagoon process, biological aerated filter, and activated sludge. Lab-scale studies showed that >50% BPA can be removed by sewage sludge estimated with the BPA solid water distribution coefficients, which showed that sludge adsorption played an important role on BPA removal. The theoretically predicted removal of BPA in municipal WWTP showed that it is readily biodegradable, which deviate from its on-site investigations. Existence of BPA conjugates in raw municipal wastewater as well as newly produced BPA degraded or migrated from microplastic materials are possible two main reasons.
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•Removals of BPA and its analogues in municipal WWTPs were summarized and analyzed.•BPA removal differences among different treatment processes were given.•BPA removals by adsorption and biodegradation were discussed.•Factors influencing BPA removals were summarized and discussed.
In today’s society, the application of information technology is becoming more and more extensive. At the same time, management accounting, as an important branch of modern accounting, also ushered ...in new development opportunities, and the research of data mining also pays more attention to the combination of theory and practice. Therefore, data mining can provide some technical support for the implementation of strategic management accounting. Because the most important thing of management accounting informatization is to process, calculate and transmit the business information of the enterprise through the corresponding information processing platform through the use of computer technology, and provide the corresponding data to the management of the major companies in order to better analyze and make decisions and perfect the future development strategy of the enterprise, so the screening of the corresponding technology is more important in the process of management accounting informatization. Based on the development of artificial intelligence technology and the combination of data mining and XBRL technology, this paper discusses the new strategies of contemporary management accounting development.
Two crustal cross sections through the eastern margin of the Tibetan Plateau are jointly determined from deep seismic sounding. The E–W trending line AA’ passes through the western Sichuan plateau ...(including the Songpan‐Garze terrane and the Longmenshan fault belt) and ends in the Sichuan basin (a part of the Yangtze craton). Line BB’ has a trend of NNE and crosses the Songpan‐Garze terrane. Two‐dimensional crustal structures along the profiles were jointly determined by the additional use of existing deep seismic sounding data. Our seismic velocity models indicate that the western Sichuan plateau and the Sichuan basin have crustal thicknesses of 62 and 43 km, average crustal P wave velocities of 6.27 and 6.45 km/s and lower crustal (Vp > 6.5 km/s) thicknesses of 27 and 15 km, respectively. Density models constructed from the seismic velocity models are consistent with observed Bouguer gravity anomalies. We infer that collision between the Tibetan Plateau and the Yangtze craton has caused thickening of the lower crust and uplift of the western Sichuan plateau. We detect a low‐velocity layer in the upper crust of the western Sichuan plateau but observe no equivalence in the Sichuan basin; west dipping thrusts may detach into this low‐velocity layer. The seismic phase PmP in the western Sichuan plateau has low amplitude, suggesting high attenuation in the lower crust (Qp of 100–300). We suggest that the high attenuation is a consequence of lower crustal flow caused by the large lower crustal thickness beneath the western Sichuan plateau.
To evaluate BPA's potential risk to health, it is important to know human daily intake. This study describes a simple but effective method to estimate the levels of human BPA intake among four ...different populations based on urinary concentration data. Nationally, of the 30 countries examined, the top ten countries for adult intake were Italy, Sweden, Denmark, France, Cyprus, Australia, Israel, Ghana, Jamaica, and Belgium. When the urinary excretion sample size was large enough and over 1000, it was found that the national estimated BPA daily intakes in the child group among countries, showed a good linear relationship with those of their corresponding adult group. Except the infant group with limited data, the global estimated BPA daily intakes for children and pregnant women were 2 and 1.4 times that of the adult group. Although the national and global estimated BPA daily intakes were generally below the temporary tolerable daily intake (tTDI) recommended by the European Food Safety Authority (EFSA), but some normal individuals' daily intakes exceeded the tTDI.
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•A simple but effective method to estimate human BPA daily intake is given.•Urinary excretion sample size is an important factor for the estimation.•Global BPA daily intakes among four different populations are presented.•Global BPA daily intake in adult groups showed linear relationship with that of Children group.
Important findings: With the human urinary concentration data, the worldwide daily intakes of BPA were successfully provided.
Diabetes mellitus is a complicated metabolic disease that has become one of the fastest-growing health crises in modern society. Diabetic patients may suffer from various complications, and diabetic ...foot is one of them. It can lead to increased rates of lower-extremity amputation and mortality, even seriously threatening the life and health of patients. Because its healing process is affected by various factors, its management and treatment are very challenging. To address these problems, smart biomaterials have been developed to expedite diabetic wound closure and improve treatment outcomes. This review begins with a discussion of the basic mechanisms of wound recovery and the limitations of current dressings used for diabetic wound healing. Then, the categories and characteristics of the smart biomaterial scaffolds, which can be utilized as a delivery system for drugs with anti-inflammatory activity, bioactive agency, and antibacterial nanoparticles for diabetic wound treatment were described. In addition, it can act as a responsive system to the stimulus of the pH, reactive oxygen species, and glucose concentration from the wound microenvironment. These results show that smart biomaterials have an enormous perspective for the treatment of diabetic wounds in all stages of healing. Finally, the advantages of the construction of smart biomaterials are summarized, and possible new strategies for the clinical management of diabetic wounds are proposed.
Previous research has proposed different types for and contingency factors affecting information technology governance. Yet, in spite of this valuable work, it is still unclear through what ...mechanisms IT governance affects organizational performance. We make a detailed argument for the mediation of strategic alignment in this process. Strategic alignment remains a top priority for business and IT executives, but theory-based empirical research on the relative importance of the factors affecting strategic alignment is still lagging. By consolidating strategic alignment and IT governance models, this research proposes a nomological model showing how organizational value is created through IT governance mechanisms. Our research model draws upon the resource-based view of the firm and provides guidance on how strategic alignment can mediate the effectiveness of IT governance on organizational performance. As such, it contributes to the knowledge bases of both alignment and IT governance literatures. Using dyadic data collected from 131 Taiwanese companies (cross-validated with archival data from 72 firms), we uncover a positive, significant, and impactful linkage between IT governance mechanisms and strategic alignment and, further, between strategic alignment and organizational performance. We also show that the effect of IT governance mechanisms on organizational performance is fully mediated by strategic alignment. Besides making contributions to construct and measure items in this domain, this research contributes to the theory base by integrating and extending the literature on IT governance and strategic alignment, both of which have long been recognized as critical for achieving organizational goals.
Metal–organic frameworks (MOFs) as photocatalysts and photocatalyst supports combine several advantages of homogeneous and heterogeneous catalyses, including stability, post‐reaction separation, ...catalyst reusability, and tunability, and they have been intensively studied for photocatalytic applications. There are several reviews that focus mainly or even entirely on experimental work. The present review is intended to complement those reviews by focusing on computational work that can provide a further understanding of the photocatalytic properties of MOF photocatalysts. We first present a summary of computational methods, including density functional theory, combined quantum mechanical and molecular mechanical methods, and force fields for MOFs. Then, computational investigations on MOF‐based photocatalysis are briefly discussed. The discussions focus on the electronic structure, photoexcitation, charge mobility, and photoredox catalysis of MOFs, especially the widely studied UiO‐66‐based MOFs.
Metal–organic frameworks (MOFs) have many advantages as heterogeneous photocatalysts or photocatalytic supports. This review explains the computational tools used to understand the mechanisms and identify potential new photocatalysts, and it discusses theoretical work on this subject.
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