Objective
To assess the accuracy of dynamic computer‐assisted implant surgery.
Materials and methods
An electronic search up to March 2020 was conducted using PubMed, Embase, and the Cochrane Central ...Register of Controlled Trial to identify studies using dynamic navigation in implant surgery, and additional manual search was performed as well. Clinical trials and model studies were selected. The primary outcome was accuracy. A single‐arm meta‐analysis of continuous data was conducted. Meta‐regression was utilized for comparison on study design, guidance method, jaw, and systems.
Results
Ten studies, four randomized controlled trials (RCT) and six prospective studies, met the inclusion criteria. A total of 1,298 drillings and implants were evaluated. The meta‐analysis of the accuracy (five clinical trials and five model studies) revealed average global platform deviation, global apex deviation, and angular deviation were 1.02 mm, 95% CI (0.83, 1.21), 1.33 mm, 95% CI (0.98, 1.67), and 3.59°, 95% CI (2.09, 5.09). Meta‐regression shown no difference between model studies and clinical trials (p = .295, 0.336, 0.185), drilling holes and implant (p = .36, 0.279, 0.695), maxilla and mandible (p = .875, 0.632, 0.281), and five different systems (p = .762, 0.342, 0.336).
Conclusion
Accuracy of dynamic computer‐aided implant surgery reaches a clinically acceptable range and has potential in clinical usage, but more patient‐centered outcomes and socio‐economic benefits should be reported.
By virtue of the layered structure, van der Waals (vdW) magnets are sensitive to the lattice deformation controlled by the external strain, providing an ideal platform to explore the one‐step ...magnetization reversal that is still conceptual in conventional magnets due to the limited strain‐tuning range of the coercive field. In this study, a uniaxial tensile strain is applied to thin flakes of the vdW magnet Fe3GeTe2 (FGT), and a dramatic increase of the coercive field (Hc) by more than 150% with an applied strain of 0.32% is observed. Moreover, the change of the transition temperatures between the different magnetic phases under strain is investigated, and the phase diagram of FGT in the strain–temperature plane is obtained. Comparing the phase diagram with theoretical results, the strain‐tunable magnetism is attributed to the sensitive change of magnetic anisotropy energy. Remarkably, strain allows an ultrasensitive magnetization reversal to be achieved, which may promote the development of novel straintronic device applications.
An ultrasensitive magnetization reversal in the van der Waals magnet Fe3GeTe2 is realized by strain. Remarkably increased coercive field, Curie temperature, and transition temperature between single‐ and labyrinthine‐domain states under tensile strain are also observed. The strain‐tunable magnetism could result from the sensitive change of magnetic anisotropy energy with the theoretical results.
SAR Ship Detection Dataset (SSDD) is the first open dataset that is widely used to research state-of-the-art technology of ship detection from Synthetic Aperture Radar (SAR) imagery based on deep ...learning (DL). According to our investigation, up to 46.59% of the total 161 public reports confidently select SSDD to study DL-based SAR ship detection. Undoubtedly, this situation reveals the popularity and great influence of SSDD in the SAR remote sensing community. Nevertheless, the coarse annotations and ambiguous standards of use of its initial version both hinder fair methodological comparisons and effective academic exchanges. Additionally, its single-function horizontal-vertical rectangle bounding box (BBox) labels can no longer satisfy the current research needs of the rotatable bounding box (RBox) task and the pixel-level polygon segmentation task. Therefore, to address the above two dilemmas, in this review, advocated by the publisher of SSDD, we will make an official release of SSDD based on its initial version. SSDD’s official release version will cover three types: (1) a bounding box SSDD (BBox-SSDD), (2) a rotatable bounding box SSDD (RBox-SSDD), and (3) a polygon segmentation SSDD (PSeg-SSDD). We relabel ships in SSDD more carefully and finely, and then explicitly formulate some strict using standards, e.g., (1) the training-test division determination, (2) the inshore-offshore protocol, (3) the ship-size reasonable definition, (4) the determination of the densely distributed small ship samples, and (5) the determination of the densely parallel berthing at ports ship samples. These using standards are all formulated objectively based on the using differences of existing 75 (161 × 46.59%) public reports. They will be beneficial for fair method comparison and effective academic exchanges in the future. Most notably, we conduct a comprehensive data analysis on BBox-SSDD, RBox-SSDD, and PSeg-SSDD. Our analysis results can provide some valuable suggestions for possible future scholars to further elaborately design DL-based SAR ship detectors with higher accuracy and stronger robustness when using SSDD.
A matrix‐assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) assisted genome mining strategy was developed for the discovery of glycosyltransferase (GT) from the root of ...Platycodon grandiflorum. A di‐O‐glycosyltransferase PgGT1 was discovered and characterized that is capable of catalyzing platycoside E (PE) synthesis through the attachment of two β‐1,6‐linked glucosyl residues sequentially to the glucosyl residue at the C3 position of platycodin D (PD). Although UDP‐glucose is the preferred sugar donor for PgGT1, it could also utilize UDP‐xylose and UDP‐N‐acetylglucosamine as weak donors. Residues S273, E274, and H350 played important roles in stabilizing the glucose donor and positioning the glucose in the optimal orientation for the glycosylation reaction. This study clarified two key steps involved in the biosynthetic pathway of PE and could greatly contribute to improving its industrial biotransformation.
A MALDI MS imaging assisted genome screening strategy was developed and enabled the identification and characterization of a di‐O‐glycosyltransferase PgGT1 from Platycodon grandiflorum root.
Cholesteric liquid crystal (CLC) chiral superstructures exhibit unique features; that is, polychromatic and spin‐determined phase modulation. Here, a concept for digitalized chiral superstructures is ...proposed, which further enables the arbitrary manipulation of reflective geometric phase and may significantly upgrade existing optical apparatus. By encoding a specifically designed binary pattern, an innovative CLC optical vortex (OV) processor is demonstrated. Up to 25 different OVs are extracted with equal efficiency over a wavelength range of 116 nm. The multiplexed OVs can be detected simultaneously without mode crosstalk or distortion, permitting a polychromatic, large‐capacity, and in situ method for parallel OV processing. Such complex but easily fabricated self‐assembled chiral superstructures exhibit versatile functionalities, and provide a satisfactory platform for OV manipulation and other cutting‐edge territories. This work is a vital step towards extending the fundamental understanding and fantastic applications of ordered soft matter.
Digitalized chiral superstructures enable the generation, detection, and demultiplexing of optical vortices in a polychromatic, large‐capacity, and in situ way. Such complex but easily fabricated self‐assembled cholesteric liquid‐crystal superstructures provide a versatile platform for various cutting‐edge territories. This work brings new insights to both fundamental understanding and innovative applications of ordered soft matter.
Oxaloacetate (OAA) and L-glutamate are essential precursors for the biosynthesis of L-lysine. Reasonable control of all potentially rate-limiting steps, including the precursors supply rate, is of ...vital importance to maximize the efficiency of L-lysine fermentation process.
In this paper, we have rationally engineered the tricarboxylic acid (TCA) cycle that increased the carbon yield (from 36.18 to 59.65%), final titer (from 14.47 ± 0.41 to 23.86 ± 2.16 g L
) and productivity (from 0.30 to 0.50 g L
h
) of L-lysine by Corynebacterium glutamicum in shake-flask fermentation because of improving the OAA and L-glutamate availability. To do this, the phosphoenolpyruvate-pyruvate-oxaloacetate (PEP-pyruvate-OAA) node's genes ppc and pyc were inserted in the genes pck and odx loci, the P1 promoter of the TCA cycle's gene gltA was deleted, and the nature promoter of glutamate dehydrogenase-coding gene gdh was replaced by P
promoter that resulted in the final engineered strain C. glutamicum JL-69P
gdh. Furthermore, the suitable addition of biotin accelerates the L-lysine production in strain JL-69P
gdh because it elastically adjusts the carbon flux for cell growth and precursor supply. The final strain JL-69P
gdh could produce 181.5 ± 11.74 g L
of L-lysine with a productivity of 3.78 g L
h
and maximal specific production rate (q
) of 0.73 ± 0.16 g g
h
in fed-batch culture during adding 2.4 mg L
biotin with four times.
Our results reveal that sufficient biomass, OAA and L-glutamate are equally important in the development of L-lysine high-yielding strain, and it is the first time to verify that fed-batch biotin plays a positive role in improving L-lysine production.
Metallic transition metal dichalcogenides (TMDs) have exhibited various exotic physical properties and hold the promise of novel optoelectronic and topological devices applications. However, the ...synthesis of metallic TMDs is based on gas‐phase methods and requires high‐temperature condition. As an alternative to the gas‐phase synthetic approach, lower temperature eutectic liquid‐phase synthesis presents a very promising approach with the potential for larger‐scale and controllable growth of high‐quality thin metallic TMD single crystals. Here, the first realization of low‐temperature eutectic liquid‐phase synthesis of type‐II Dirac semimetal PtTe2 single crystals with thickness ranging from 2 to 200 nm is presented. The electrical measurement of synthesized PtTe2 reveals a record‐high conductivity of as high as 3.3 × 106 S m−1 at room temperature. Besides, the weak antilocalization behavior is identified experimentally in the type‐II Dirac semimetal PtTe2 for the first time. Furthermore, a simple and general strategy is developed to obtain atomically thin PtTe2 crystal by thinning as‐synthesized bulk samples, which can still retain highly crystalline and exhibits excellent electrical conductivity. The results of controllable and scalable low‐temperature eutectic liquid‐phase synthesis and layer‐by‐layer thinning of high‐quality thin PtTe2 single crystals offer a simple and general approach for obtaining different thickness metallic TMDs with high melting‐point transition metal.
The first low‐temperature eutectic synthesis of type‐II Dirac semimetal PtTe2 single crystals is reported, revealing a record‐high conductivity of 3.3 × 106 S m−1 at room temperature. The weak antilocalization behavior in the PtTe2 is identified experimentally. Furthermore, a general strategy is developed to obtain highly crystalline atomically thin PtTe2 crystal by thinning as‐synthesized bulk samples.
As a well-known traditional Chinese medicine (TCM) prescription, Xin-Sheng-Hua Granule (XSHG) has been applied in China for more than 30 years to treat postpartum diseases, especially anemia. ...However, underlying therapeutic mechanisms of XSHG for anemia were still unclear. In this study, plasma metabolomics profiling with UHPLC-QTOF/MS and multivariate data method was firstly analyzed to discover the potential regulation mechanisms of XSHG on anemia rats induced by bleeding from the orbit. Afterward, the compound-target-pathway network of XSHG was constructed by the use of network pharmacology, thus anemia-relevant signaling pathways were dissected. Finally, the crucial targets in the shared pathways of metabolomics and network pharmacology were experimentally validated by ELISA and Western Blot analysis. The results showed that XSHG could exert excellent effects on anemia probably through regulating coenzyme A biosynthesis, sphingolipids metabolism and HIF-1α pathways, which was reflected by the increased levels of EPOR, F2, COASY, as well as the reduced protein expression of HIF-1α, SPHK1, and S1PR1. Our work successfully explained the polypharmcological mechanisms underlying the efficiency of XSHG on treating anemia, and meanwhile, it probed into the potential treatment strategies for anemia from TCM prescription.
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