The realization of integrated, low-cost and efficient solutions for high-speed, on-chip communication requires terahertz-frequency waveguides and has great potential for information and communication ...technologies, including sixth-generation (6G) wireless communication, terahertz integrated circuits, and interconnects for intrachip and interchip communication. However, conventional approaches to terahertz waveguiding suffer from sensitivity to defects and sharp bends. Here, building on the topological phase of light, we experimentally demonstrate robust terahertz topological valley transport through several sharp bends on the all-silicon chip. The valley kink states are excellent information carriers owing to their robustness, single-mode propagation and linear dispersion. By leveraging such states, we demonstrate error-free communication through a highly twisted domain wall at an unprecedented data transfer rate (exceeding ten gigabits per second) that enables real-time transmission of uncompressed 4K high-definition video (that is, with a horizontal display resolution of approximately 4,000 pixels). Terahertz communication with topological devices opens a route towards terabit-per-second datalinks that could enable artificial intelligence and cloud-based technologies, including autonomous driving, healthcare, precision manufacturing and holographic communication.Robust terahertz wave transport is demonstrated on a silicon chip using the valley Hall topological phase. Error-free communication is achieved at a data rate of 11 Gbit s−1, enabling real-time transmission of uncompressed 4K high-definition video.
In each somatic cell of a female mammal one X chromosome is transcriptionally silenced via X-chromosome inactivation (XCI), initiating early in development. Although XCI events are conserved in mouse ...and human postimplantation development, regulation of X-chromosome dosage in preimplantation development occurs differently. In preimplantation development, mouse embryos undergo imprinted form of XCI, yet humans lack imprinted XCI and instead regulate gene expression of both X chromosomes by dampening transcription. The long non-coding RNA Xist/XIST is expressed in mouse and human preimplantation and postimplantation development to orchestrate XCI, but its role in dampening is unclear. In this review, we discuss recent advances in our understanding of the role of Xist in X chromosome dosage compensation in mouse and human.
X-inactive specific transcript (Xist) is a long non-coding RNA that remains associated with the X chromosome from which it is expressed.
Xist is unequivocally required for the imprinted form of X-chromosome inactivation (XCI) in mice in vivo, but demonstration of its indisputable requirement for random XCI in vivo is yet to be shown.
Loss of Xist expression in mice in vivo and in conventional human pluripotent stem cells correlates with partial reactivation of genes residing on the inactive X chromosome, suggesting an important role of Xist in maintenance of the silent state of genes on the inactive X chromosome.
Human preimplantation embryos have a unique X-chromosome dosage compensation state called X-chromosome dampening (XCD), where transcriptional output is tuned down from both X chromosomes. Correlative observations suggest that XCD might be mediated by XIST.
Abstract
The recently discovered non-Hermitian skin effect (NHSE) manifests the breakdown of current classification of topological phases in energy-nonconservative systems, and necessitates the ...introduction of non-Hermitian band topology. So far, all NHSE observations are based on one type of non-Hermitian band topology, in which the complex energy spectrum winds along a closed loop. As recently characterized along a synthetic dimension on a photonic platform, non-Hermitian band topology can exhibit almost arbitrary windings in momentum space, but their actual phenomena in real physical systems remain unclear. Here, we report the experimental realization of NHSE in a one-dimensional (1D) non-reciprocal acoustic crystal. With direct acoustic measurement, we demonstrate that a twisted winding, whose topology consists of two oppositely oriented loops in contact rather than a single loop, will dramatically change the NHSE, following previous predictions of unique features such as the bipolar localization and the Bloch point for a Bloch-wave-like extended state. This work reveals previously unnoticed features of NHSE, and provides the observation of physical phenomena originating from complex non-Hermitian winding topology.
Confining photons in a finite volume is highly desirable in modern photonic devices, such as waveguides, lasers and cavities. Decades ago, this motivated the study and application of photonic ...crystals, which have a photonic bandgap that forbids light propagation in all directions
. Recently, inspired by the discoveries of topological insulators
, the confinement of photons with topological protection has been demonstrated in two-dimensional (2D) photonic structures known as photonic topological insulators
, with promising applications in topological lasers
and robust optical delay lines
. However, a fully three-dimensional (3D) topological photonic bandgap has not been achieved. Here we experimentally demonstrate a 3D photonic topological insulator with an extremely wide (more than 25 per cent bandwidth) 3D topological bandgap. The composite material (metallic patterns on printed circuit boards) consists of split-ring resonators (classical electromagnetic artificial atoms) with strong magneto-electric coupling and behaves like a 'weak' topological insulator (that is, with an even number of surface Dirac cones), or a stack of 2D quantum spin Hall insulators. Using direct field measurements, we map out both the gapped bulk band structure and the Dirac-like dispersion of the photonic surface states, and demonstrate robust photonic propagation along a non-planar surface. Our work extends the family of 3D topological insulators from fermions to bosons and paves the way for applications in topological photonic cavities, circuits and lasers in 3D geometries.
Grain protein content (GPC) affects rice nutrition quality. Here, we identify two stable quantitative trait loci (QTLs), qGPC-1 and qGPC-10, controlling GPC in a mapping population derived from ...indica and japonica cultivars crossing. Map-based cloning reveals that OsGluA2, encoding a glutelin type-A2 precursor, is the candidate gene underlying qGPC-10. It functions as a positive regulator of GPC and has a pleiotropic effect on rice grain quality. One SNP located in OsGluA2 promoter region is associated with its transcript expression level and GPC diversity. Polymorphisms of this nucleotide can divide all haplotypes into low (OsGluA2
) and high (OsGluA2
) expression types. Population genetic and evolutionary analyses reveal that OsGluA2
, mainly present in japonica accessions, originates from wild rice. However, OsGluA2
, the dominant type in indica, is acquired through mutation of OsGluA2
. Our results shed light on the understanding of natural variations of GPC between indica and japonica subspecies.
We propose a single low-profile skin metasurface carpet cloak to hide objects with arbitrary shape and size under three different waves, i.e., electromagnetic (EM) waves, acoustic waves and water ...waves. We first present a metasurface which can control the local reflection phase of these three waves. By taking advantage of this metasurface, we then design a metasurface carpet cloak which provides an additional phase to compensate the phase distortion introduced by a bump, thus restoring the reflection waves as if the incident waves impinge onto a flat mirror. The finite element simulation results demonstrate that an object can be hidden under these three kinds of waves with a single metasurface cloak.
Origami is the art of folding two‐dimensional (2D) materials, such as a flat sheet of paper, into complex and elaborate three‐dimensional (3D) objects. This study reports origami‐based metamaterials ...whose electromagnetic responses are dynamically controllable via switching the folding state of Miura‐ori split‐ring resonators. The deformation of the Miura‐ori unit along the third dimension induces net electric and magnetic dipoles of split‐ring resonators parallel or anti‐parallel to each other, leading to the strong chiral responses. Circular dichroism as high as 0.6 is experimentally observed while the chirality switching is realized by controlling the deformation direction and kinematics. In addition, the relative density of the origami metamaterials can be dramatically reduced to only 2% of that of the unfolded structure. These results open a new avenue toward lightweight, reconfigurable, and deployable metadevices with simultaneously customized electromagnetic and mechanical properties.
An approach toward reconfigurable metamaterials with simultaneously customized electromagnetic and mechanical properties is presented. Strong chiroptical responses are induced when transforming a planar, achiral metasurface into 3D origami metamaterials, and breaking the mirror symmetry of the folded origami metamaterials. The relative density of the origami metamaterials can be dramatically reduced to only 2% of that of the unfolded structure.
At photonic Dirac points, electromagnetic waves are governed by the same equations as two-component massless relativistic fermions. However, photonic Dirac points are known to occur in pairs in ..."photonic graphene" and other similar photonic crystals, which necessitates special precautions to excite only one valley state. Systems hosting unpaired photonic Dirac points are significantly harder to realize, as they require broken time-reversal symmetry. Here, we report on the observation of an unpaired Dirac point in a planar two-dimensional photonic crystal. The structure incorporates gyromagnetic materials, which break time-reversal symmetry; the unpaired Dirac point occurs when a parity-breaking parameter is fine-tuned to a topological transition between a photonic Chern insulator and a conventional photonic insulator phase. Evidence for the unpaired Dirac point is provided by transmission and field-mapping experiments, including a demonstration of strongly non-reciprocal reflection. This unpaired Dirac point may have applications in valley filters and angular selective photonic devices.
Topological photonics has emerged as a promising field in photonics that is able to shape the science and technology of light. As a significant degree of freedom, valley is introduced to design and ...construct photonic topological phases, with encouraging recent progress in applications ranging from on‐chip communications to terahertz lasers. Herein, the development of topological valley photonics is reviewed, from both perspectives of fundamental physics and practical applications. The unique valley‐contrasting physics determines that the bulk topology and the bulk‐boundary correspondence in valley photonic topological phases exhibit different properties from other photonic topological phases. Valley conservation allows not only robust propagation of light through sharp corners, but also 100% out‐coupling of topological states to the surrounding environment. Finally, robust valley transport requires no magnetic materials or the complex construction of photonic pseudospin and, thus, can be integrated on compact photonic platforms for future technologies.
Topological photonics offers new possibilities to manipulate light in robust manners. Among different photonic topological phases, photonic valley‐Hall phase is quite promising for future technologies due to its simple design and excellent performance. This article reviews the developments in studying topological valley photonics, which covers both fundamental physics and device applications.
Topological phases have been studied in photonic, acoustic and phononic metamaterials, promising a range of applications. Such topological modes usually stem from collective resonant effects in ...periodic lattices. One may, therefore, expect similar features to be forbidden for thermal diffusion that is purely dissipative and mostly incoherent, prohibiting collective resonances. Here we report the discovery of diffusion-based topological states supported by spatiotemporally modulated advections stacked over a fluidic surface. This arrangement imitates a periodic propagating potential in an effective thermal lattice. We observe edge states in topologically non-trivial and bulk states in topologically trivial lattices. Interface states form at boundaries between these two types of lattice, manifesting inhomogeneous thermal properties on the fluidic surface. Our findings establish a framework for topological diffusion and thermal edge or bulk states, and it may allow a distinct mechanism for the flexible manipulation of diffusive phenomena for robust heat and mass transfer.Topological effects have been found in a range of classical-wave systems, but it was unclear if the concept could be extended to diffusion. An approach using spatiotemporal modulations has now implemented them in a diffusive system
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