Reel Inequality Yuen, Nancy Wang
2016, 20161212, 2016-12-12
eBook
When the 2016 Oscar acting nominations all went to whites for the second consecutive year, #OscarsSoWhite became a trending topic. Yet these enduring racial biases afflict not only the Academy ...Awards, but also Hollywood as a whole. Why do actors of color, despite exhibiting talent and bankability, continue to lag behind white actors in presence and prominence?
Reel Inequalityexamines the structural barriers minority actors face in Hollywood, while shedding light on how they survive in a racist industry. The book charts how white male gatekeepers dominate Hollywood, breeding a culture of ethnocentric storytelling and casting. Nancy Wang Yuen interviewed nearly a hundred working actors and drew on published interviews with celebrities, such as Viola Davis, Chris Rock, Gina Rodriguez, Oscar Isaac, Lucy Liu, and Ken Jeong, to explore how racial stereotypes categorize and constrain actors. Their stories reveal the day-to-day racism actors of color experience in talent agents' offices, at auditions, and on sets. Yuen also exposes sexist hiring and programming practices, highlighting the structural inequalities that actors of color, particularly women, continue to face in Hollywood.
This book not only conveys the harsh realities of racial inequality in Hollywood, but also provides vital insights from actors who have succeeded on their own terms, whether by sidestepping the system or subverting it from within. Considering how their struggles impact real-world attitudes about race and diversity,Reel Inequalityfollows actors of color as they suffer, strive, and thrive in Hollywood.
Gliomas comprise heterogeneous malignant glial and stromal cells. While blood vessel co-option is a potential mechanism to escape anti-angiogenic therapy, the relevance of glial phenotype in this ...process is unclear. We show that Olig2+ oligodendrocyte precursor-like glioma cells invade by single-cell vessel co-option and preserve the blood-brain barrier (BBB). Conversely, Olig2-negative glioma cells form dense perivascular collections and promote angiogenesis and BBB breakdown, leading to innate immune cell activation. Experimentally, Olig2 promotes Wnt7b expression, a finding that correlates in human glioma profiling. Targeted Wnt7a/7b deletion or pharmacologic Wnt inhibition blocks Olig2+ glioma single-cell vessel co-option and enhances responses to temozolomide. Finally, Olig2 and Wnt7 become upregulated after anti-VEGF treatment in preclinical models and patients. Thus, glial-encoded pathways regulate distinct glioma-vascular microenvironmental interactions.
•Glial phenotype regulates glioma co-option or angiogenesis•Glioma oligodendrocyte-like (OPCL) cells express Wnt7 necessary for co-option•Wnt inhibitors significantly improve survival with temozolomide•Anti-VEGF-treatment of glioma selects for Olig2/Wnt7+ cells
Griveau et al. show that Olig2+ glioma cells invade by single-cell vessel co-option, whereas Olig2− glioma cells promote angiogenesis and that anti-VEGF treatment selects for the Olig2+/Wnt7+ phenotype. Wnt7 is necessary for vessel co-option, and Wnt inhibition enhances the response to temozolomide treatment.
Asian Americans and Pacific Islanders on TV ducros, faustina m.; chin, christina b.; lee, jenny jong-hwa ...
Contexts (Berkeley, Calif.),
11/2018, Volume:
17, Issue:
4
Journal Article
Open access
Representation in media matters–so why is prime time still so white?
Playing “Ghetto” Nancy Wang Yuen
Black Los Angeles,
04/2010
Book Chapter
As I sit across from a beautiful black woman with long, flowing hair, I feel like I am in the presence of a movie star. Although she is not a recognizable celebrity, Vivian’s melodious voice and ...elegant movements underscore her background as a dancer and actor. Donning a red cashmere sweater, she tells me how her privileged upbringing has shaped her acting sensibilities despite the stereotyped, “South Central ghetto” roles she is typically offered to play. Vivian is one of many black actors in Los Angeles whose life experience bears no resemblance to the South Central stereotyped roles typically available
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