We report a new search of weakly interacting massive particles (WIMPs) using the combined low background data sets in 2016 and 2017 from the PandaX-II experiment in China. The latest data set ...contains a new exposure of 77.1 live day, with the background reduced to a level of 0.8\(\times10^{-3}\) evt/kg/day, improved by a factor of 2.5 in comparison to the previous run in 2016. No excess events were found above the expected background. With a total exposure of 5.4\(\times10^4\) kg day, the most stringent upper limit on spin-independent WIMP-nucleon cross section was set for a WIMP with mass larger than 100 GeV/c\(^2\), with the lowest exclusion at 8.6\(\times10^{-47}\) cm\(^2\) at 40 GeV/c\(^2\).
We search for nuclear recoil signals of dark matter models with a light mediator in PandaX-II, a direct detection experiment in China Jinping underground Laboratory. Using data collected in 2016 and ...2017 runs, corresponding to a total exposure of 54 ton day, we set upper limits on the zero-momentum dark matter-nucleon cross section. These limits have a strong dependence on the mediator mass when it is comparable to or below the typical momentum transfer. We apply our results to constrain self-interacting dark matter models with a light mediator mixing with standard model particles, and set strong limits on the model parameter space for the dark matter mass ranging from \(5~{\rm GeV}\) to \(10~{\rm TeV}\).
Notch signaling has been reported to play an essential role in tumorigenesis. Several studies have suggested that Notch receptors could be oncoproteins or tumor suppressors in different types of ...human cancers. Emerging evidence has suggested that Notch pathway regulates cell growth, apoptosis, cell cycle, and metastasis. In the current study, we explore whether Notch-1 could regulate the cell invasion and migration as well as EMT (epithelial-mesenchymal transition) in prostate cancer cells. We found that overexpression of Notch-1 enhanced cell migration and invasion in PC-3 cells. However, downregulation of Notch-1 retarded cell migration and invasion in prostate cancer cells. Importantly, we observed that overexpression of Notch-1 led to EMT in PC-3 cells. Notably, we found that EMT-type cells are associated with EMT markers change and cancer stem cell phenotype. Taken together, we concluded that downregulation of Notch-1 could be a promising approach for inhibition of invasion in prostate cancer cells, which could be useful for the treatment of metastatic prostate cancer.
Objective To investigate the effect of quality control circle (QCC) activities in improving the accuracy of inhalants usage in patients with chronic obstructive pulmonary disease (COPD). Methods A ...QCC team was established to conduct problem-solving QCC activities. The current situation and factors of inhalants usage in COPD patients were analyzed. Targeted nursing countermeasures were carried out including comprehensive health education, standard operating procedure, enhanced training and evaluation, and diversified exercise of respiratory function. Results The accuracy rate of inhalants usage in COPD patients was increased form 58. 25% before implementation of QCC activities to 83. 06% after implementation of QCC activities. Conclusion The QCC is effective to improve the accuracy of inhalants usage in COPD patients. (目的 开展品管圈活动提高慢性阻塞性肺疾病(COPD)患者吸入剂的规范使用率。方法 成立品管圈圈组, 开展问题解决型品管圈活动, 通过现状把握、原因分析、制定了针对性的对策并予以实施, 包括打造无死角的宣教环境, 简单化、专业化、标准化完善操作流程, 加强培训夯实知识、质控考核提高水平和多元化、精细化进行呼吸功能锻炼。结果 COPD患者吸入剂的规范使用率由品管圈活动开展前的58. 25%
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