The arrival of the digital information age has realized the transformation of people’s production and lifestyle, which has also promoted the vigorous development of the art field. At present, the ...application of informatization in oil painting techniques is increasing. The purpose of this paper is to realize the research on the visual planarization of oil painting techniques in the digital information environment to promote the ecological development of the computer and art field. By using the advanced methods and technologies of its information display, this paper proposed the use of image processing algorithms in the digital information age to guide the integration of digital information technology and oil painting techniques. This helped to analyze and solve objective problems such as the profound meaning of the objective existence in the art field and the inability to understand the emotion in it. It can be seen from the analysis of the oil painting color model that, in the RGB model, when the wavelength is within a certain range, it can be used. But when the wavelength is between 444 nanometers and 526 nanometers, the red intensity is too low. That is to say, it can not effectively express its corresponding color in this wavelength range. This model is very challenging. In the XYZ color model, when the wavelength is in a certain region, the output of red light becomes a value less than 0. Any color in this space can be well represented by a linear combination of X, Y, and Z. Therefore, the study of visual flattening of oil painting is very important in the field of art.
Starch digestibility strongly depends on the food composition and microstructure formed during food processing. Identifying the interplay among food ingredients is vital to design starch-based foods ...with low digestibility. In this work, the effects of native and enzymatic (pepsin and pancreatin) hydrolyzed rice proteins on structural features, enzyme activity and digestibility of cooked rice starch were systematically investigated. All protein and its hydrolysates showed potent abilities in mitigating starch digestion. Native and pepsin hydrolyzed proteins increased starch retrogradation extent and thus increased ordered and aggregated structures of cooked starch. Pepsin-pancreatin hydrolyzed proteins displayed anti-retrogradation activity and decreased starch ordered structures, however, increased V-type inclusion complexes and displayed a potent mixed-type (competitive and non-competitive) inhibitory activity against α-amylase. Based on these findings, it can be concluded that native and pepsin hydrolyzed proteins decreased starch digestibility via increasing ordered structures of cooked starch, while pepsin-pancreatin hydrolyzed proteins mitigated starch digestion by the synergistic effects of V-type structures enhancement and mixed-type suppression activity against α-amylase. The data is of significant to formulate low glycemic health-promoting food products via native or proteolytic proteins complexation.
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•Pepsin and pepsin-pancreatin hydrolyzed rice proteins were prepared.•Native and enzymatically hydrolyzed rice proteins mitigated starch digestibility.•Native and pepsin treated proteins increased ordered and aggregated structures of cooked starch.•Pepsin-pancreatin hydrolyzed proteins increased starch V-type structures.•Proteins treated with pepsin-pancreatin suppressed the activity of α-amylase.
The pivotal regulatory role of non-coding RNAs (ncRNAs), especially exosomal ncRNAs, in ferroptosis significantly influences cancer cell fate. This review explores their involvement across various ...human cancers, focusing on microRNAs (miRNA), long non-coding RNAs (lncRNA), and circular RNAs (circRNA). These ncRNAs either stimulate or inhibit ferroptosis by targeting key components, impacting cancer susceptibility to this form of cell death. Specific studies in lung, gastric, liver, cervical, bladder, pancreatic, and osteosarcoma cancers underscore the crucial role of exosomal ncRNAs in modulating ferroptosis, influencing cancer progression, and therapeutic responses. Emphasizing the therapeutic potential of exosomal ncRNAs, we discuss their ability to deliver circRNA, miRNA, and lncRNA to target cells. Despite being in early stages with challenges in bioengineering for drug delivery, these studies hold promise for future clinical applications. Noteworthy findings include inhibiting exosome production to overcome ferroptosis resistance in lung adenocarcinoma and the potential of exosomal DACT3-AS1 to sensitize gastric cancer cells to ferroptosis. The review concludes by highlighting exosomal ncRNAs like miR-4443 and miR-660–5p as promising therapeutic targets, offering avenues for precise cancer interventions by modulating signaling pathways and sensitizing cells to ferroptosis. Overall, this review enhances our understanding of cancer pathogenesis and presents new horizons for targeted therapeutic interventions, revealing the intricate interplay between exosomal ncRNAs and ferroptosis.
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•Ferroptosis-related non-coding RNAs are novel regulators in cancers.•Delivering tumor suppressive exosomal non-coding RNAs hinders tumor progression.•Inhibition of oncogene exosomal non-coding RNAs overcomes ferroptosis resistance.
Colorectal cancer (CRC) poses a significant global health challenge, ranking as the third most diagnosed cancer and the second leading cause of cancer-related deaths. Despite advancements in ...treatment, challenges such as delayed diagnosis, multidrug resistance, and limited therapeutic effectiveness persist, emphasizing the need for innovative approaches. This review explores the potential of natural products, nutraceuticals, and phytochemicals for targeting ferroptosis-related regulators as a novel strategy in CRC. Ferroptosis, a form of regulated cell death characterized by iron-dependent lethal lipid peroxide accumulation, holds substantial importance in CRC progression and therapy resistance. Natural products, known for their diverse bioactive effects and favorable safety profiles, emerge as promising candidates to induce ferroptosis in CRC cells. Exploring amino acid, iron, lipid metabolism regulators, and oxidative stress regulators reveals promising avenues for inducing cell death in CRC. This comprehensive review provides insights into the multifaceted effects of natural products on proteins integral to ferroptosis regulation, including GPX4, SLC7A11, ACSL4, NCOA4, and HO-1. By elucidating the intricate mechanisms through which natural products modulate these proteins, this review lays the foundation for a promising therapeutic strategy in CRC.
•First survey of neonic residues in total dietary samples consumed by Chinese adults.•Health risks of chronic exposure to neonics were investigated for the Chinese population by a TDS.•10 neonics ...were analyzed in 528 composite dietary samples from two consecutive TDS.•Dietary intake may be one of the major pathways for human exposure to neonics.
Neonicotinoid insecticides are ubiquitous in food and the environment due to their wide use. Growing evidence suggests the adverse effects of neonicotinoids in many species, including mammals. Some studies have reported the urinary concentrations of neonicotinoids in human biological monitoring, but the potential risks of neonicotinoids on human health based on long-term chronic exposure studies in any general population have been rarely tackled. In this study, the dietary exposure to neonicotinoids of the Chinese adult population was studied on the basis of composite dietary samples collected from the 5th (2009–2012) and 6th (2015–2018) Chinese total diet studies (TDS). Residue levels of ten neonicotinoids were determined in 528 composite dietary samples from 24 provinces in China. Most of the samples (53.3% and 70.5% in the 5th and 6th TDS, respectively) that we analyzed contained the multi-residue of neonicotinoids. Imidacloprid and acetamiprid were the most frequently detected neonicotinoids, and thiamethoxam and clothianidin were increasingly used and found in the 6th TDS. The estimated daily intake (EDI) for total neonicotinoids was calculated to evaluate health risk of the Chinese adult population based on a relative potency factor assessment method. The mean EDIs of total neonicotinoids in the 5th and 6th TDS respectively reached 598.95 and 710.38 ng/kg bw per day. Although the mean EDIs of total neonics in 6th TDS was relatively higher than that in 5th TDS, no statistical difference was observed (p > 0.05). Vegetables were the main source of dietary exposure, but exposure via cereals and beverages and water must also be addressed in China. Although the average exposure for total neonicotinoids was much lower than the current chronic reference dose (57 μg/kg bw per day), the dietary exposure risks of a general population for total neonicotinoids should not be overlooked due to the ubiquity of neonicotinoids in food and the environment.
Small-molecule inhibitors of PARP are thought to mediate their antitumor effects as catalytic inhibitors that block repair of DNA single-strand breaks (SSB). However, the mechanism of action of PARP ...inhibitors with regard to their effects in cancer cells is not fully understood. In this study, we show that PARP inhibitors trap the PARP1 and PARP2 enzymes at damaged DNA. Trapped PARP-DNA complexes were more cytotoxic than unrepaired SSBs caused by PARP inactivation, arguing that PARP inhibitors act in part as poisons that trap PARP enzyme on DNA. Moreover, the potency in trapping PARP differed markedly among inhibitors with niraparib (MK-4827) > olaparib (AZD-2281) >> veliparib (ABT-888), a pattern not correlated with the catalytic inhibitory properties for each drug. We also analyzed repair pathways for PARP-DNA complexes using 30 genetically altered avian DT40 cell lines with preestablished deletions in specific DNA repair genes. This analysis revealed that, in addition to homologous recombination, postreplication repair, the Fanconi anemia pathway, polymerase β, and FEN1 are critical for repairing trapped PARP-DNA complexes. In summary, our study provides a new mechanistic foundation for the rational application of PARP inhibitors in cancer therapy.
Summary Background Preterm birth is the leading cause of child death in children younger than 5 years. Large cohort studies in developed countries have shown that maternal hepatitis B virus infection ...is associated with preterm birth, but there is little reliable evidence from China and other developing countries, where hepatitis B virus prevalence is intermediate or high. Hence, we designed this study to investigate the association between pre-pregnancy hepatitis B virus infection and risk of preterm and early preterm birth. Methods Between Jan 1, 2010, and Dec 31, 2012, we did a population-based cohort study using data from 489 965 rural women aged 21–49 years who had singleton livebirths from 220 counties of China who participated in the National Free Preconception Health Examination Project. Participants were divided into three groups according to their pre-pregnancy status of hepatitis B virus infection: women uninfected with hepatitis B virus (control group), women who were HBsAg positive and HBeAg negative (exposure group 1), and women who were both HBsAg and HBeAg positive (exposure group 2). The primary outcome was preterm birth (gestation at less than 37 weeks). We used log-binomial regression to estimate adjusted risk ratios (aRR) of preterm birth for women with pre-pregnancy hepatitis B virus infection, and risk of early preterm birth (gestation less than 34 weeks). Findings 489 965 women met inclusion criteria and were included in this study; of these, 20 827 (4·3%) were infected with hepatitis B virus. Compared with women who were not infected with hepatitis B virus, women who were HBsAg positive and HBeAg negative had a 26% higher risk of preterm birth (aRR 1·26, 95% CI 1·18–1·34) and women who were both HBsAg and HBeAg positive had a 20% higher risk of preterm birth (aRR 1·20, 1·08–1·32). Compared with women who were not infected with hepatitis B virus, women who were HBsAg positive and HBeAg negative manifested an 18% higher risk of early preterm birth (gestation less than 34 weeks; aRR 1·18, 1·04–1·34) and women who were both HBsAg and HBeAg positive had a 34% higher risk of early preterm birth (aRR 1·34, 1·10–1·61). Maternal pre-pregnancy hepatitis B virus infection was independently associated with higher risk of preterm birth and early preterm birth. These associations were similar in subgroups of participants as defined by baseline characteristics. Interpretation Besides mother-to-child transmission, the risk of preterm birth in women infected with hepatitis B virus should not be neglected. Comprehensive programmes that focus on early detection of hepatitis B virus infection before pregnancy and provide appropriate medical intervention for women infected with hepatitis B virus before and during pregnancy would be helpful in improving maternal and neonatal outcomes and reducing child mortality. Funding Chinese Association of Maternal and Child Health Studies.
In order to study the influence of slit structure on the blasting effect of slit charge, the super dynamic strain test system and photographic equipment were used to study the dynamic response of ...slit charge blasting and the distribution of blasting cracks under different slit shapes and slit angles. The results show that changing the shape of the slit does not make the energy-gathering and damage-reducing blasting effect of the slit cartridge disappear, but it will affect its effect. Compared with the round hole slit, the peak strain in the slit direction of the strip slit cartridge blast is larger, the directional crack forming is more obvious, and the blasting effect is better. The energy accumulation and loss reduction effect of the blasting of the strip slotted cartridge increase first and then decrease with the increase of the slit angle. When the slit angle is 20°, the energy accumulation and loss reduction effect of strip slit charge blasting are the largest, the distribution of blasting cracks is the best, and the directional fracture blasting effect of slit charge is the best. Finally, based on the research results of model test, combined with the actual situation of the construction site, the slotted cartridge is applied to the pre-splitting blasting of open-pit slope. Compared with the ordinary cartridge pre-splitting blasting, the slope roughness after blasting is reduced by 46.2%, the half-hole rate of blast hole is increased by 20.5%, the blasting vibration intensity is reduced by 60.3%, and the directional fracture control blasting effect is good.
Targeted therapies against non-small-cell lung cancer (NSCLC) harboring
mutations remain an unmet need. In this study, we assessed the efficacy and safety of pyrotinib in patients with
-mutant ...advanced NSCLC in a prospective, multicenter, open-label, single-arm, phase II study.
Patients with stage IIIB or IV
-mutant lung adenocarcinoma who were previously treated with platinum-based chemotherapy were enrolled to receive pyrotinib at a dose of 400 mg/d for 21-day cycles. The primary end point was objective response rate per independent review committee (IRC).
Between October 20, 2016, and December 10, 2018, 60 patients received pyrotinib monotherapy. At baseline, 58 (96.7%) were stage IV, and 25 (41.7%) received at least 2 lines of prior chemotherapy. As of data cutoff on June 20, 2019, IRC-assessed objective response rate was 30.0% (95% CI, 18.8% to 43.2%). All subgroups of patients with different
mutation types showed a favorable objective response rate. The objective response rates were similar between patients with and without brain metastases (25.0%
31.3%). The median duration of response was 6.9 months (95% CI, 4.9 to 11.1 months). The median progression-free survival was 6.9 months (95% CI, 5.5 to 8.3 months) per IRC. The median overall survival was 14.4 months (95% CI, 12.3 to 21.3 months). Treatment-related adverse events of grade 3 or 4 occurred in 28.3% of patients, with the most common being diarrhea (20.0%; all grade 3). No treatment-related deaths were reported.
Pyrotinib showed promising antitumor activity and an acceptable safety profile in chemotherapy-treated patients with
-mutant NSCLC.
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