An explicit form of the elastic strain-energy function for direction-dependent large elastic strain behaviors of soft fiber-reinforced composites is first presented based upon a decoupled approach ...for simulating complex nonlinear coupling effects. From this form, the exact closed-form solutions are then obtained for the uniaxial tension responses in the fiber and cross-fiber directions. With such exact solutions, the issue of simultaneously simulating strongly coupling nonlinear responses in the fiber and cross-fiber directions may be reduced to the issue of separately treating each decoupled uniaxial stress-strain response, thus bypassing usual complexities and uncertainties involved in identifying a large number of strongly coupled adjustable parameters. The numerical examples given are in good agreement with the experimental data for large strain responses.
Bamboo leaf-like CuO(b) and flaky-shaped CuO(f) were prepared by the hydrothermal method, and then combined with Al nanoparticles to form Al/CuO(b) and Al/CuO(f) by the ultrasonic dispersion method. ...The phase, composition, morphology, and structure of the composites were characterized by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), and energy scattering spectrometer (EDS). The compatibility of CuO, Al/CuO and nitrocellulose (NC) was evaluated by differential scanning calorimetry (DSC). The effects of CuO and Al/CuO on the thermal decomposition of NC were also studied. The results show that the thermal decomposition reactions of CuO-NC composite, Al/CuO-NC composite, and NC follow the same kinetic mechanism of Avrami-Erofeev equation. In the cases of CuO and Al/CuO, they could promote the O-NO2 bond cleavage and secondary autocatalytic reaction in condensed phase. The effects of these catalysts have some difference in modifying the thermolysis process of NC due to the microstructures of CuO and the addition of Al nanopowders. Furthermore, the presence of Al/CuO(f) can make the Al/CuO(f)-NC composite easier to ignite, whereas the composites have strong resistance to high temperature. Compatibility and thermal safety analysis showed that the Al/CuO had good compatibility with NC and it could be used safely. This contribution suggests that CuO and Al/CuO played key roles in accelerating the thermal decomposition of NC.
Background
Arylsulfatase D (ARSD) belongs to the sulfatase family and plays a crucial role in maintaining the proper structure of bone and cartilage matrix. Although several researches have revealed ...the functions of ARSD in tumor progression, the prognostic value of ARSD in glioma and the related mechanisms have not been fully investigated.
Methods
We performed a pan-cancer analysis of ARSD, and investigated the relationship between expression of ARSD and overall survival (OS) in multiple glioma datasets. ROC curves and nomograms were created to investigate the predictive capacity of ARSD. Immune and analysis were conducted to investigate the mechanisms underlying the roles of ARSD in glioma. Glioma tissue samples were collected to verify the expression of ARSD in glioma, while the functions of ARSD were explored using cell experiment. M2 macrophage infiltration assay was used to determine the relation between ARSD and tumor immune microenvironment.
Results
Survival analysis indicated that individuals with high ARSD expression in glioma had a shorter survival time. Cox analysis showed that ARSD had a good ability for predicting prognosis in glioma. Immune analysis suggested that ARSD could regulate immune cell infiltration and affect the Cancer-Immunity Cycle to create an immunosuppressive environment. Combined with cell experiment and bioinformatic analysis, we found that ARSD can promote glioma progression through regulation of JAK2/STAT3 pathway and M2 macrophage infiltration.
Conclusion
Our study found that ARSD can promote glioma development by regulating immune microenvironment and JAK2/STAT3 signaling pathway, which provided a potential therapy target for glioma treatment.
The development of aqueous metal‐ion batteries has attracted great attention due to their relatively low cost and high safety levels. However, their practical applications are hindered by the ease at ...which their aqueous electrolytes freeze. Inspired by the antifreezing properties of salts and alcohol cryoprotective agents, a “two‐in‐one” cryoprotective agent, hydroxyl‐functionalized poly(ionic liquid) (PIL‐OH)‐based hydrogel electrolyte for aqueous lithium‐ion batteries (ALIBs) is developed. The synergy of both ionic hydration and hydrogen bond interactions between the PIL‐OH and water molecules impairs the hydrogen‐bond networks of water and depresses the freezing point of water below −80 °C. Benefiting from exceptional ultralow temperature tolerance, the prepared PIL‐OH hydrogel exhibits a highly enhanced low temperature adaptability and a high ionic conductivity of 0.08 mS cm−1 at −80 °C. The PIL‐OH hydrogel‐based flexible ALIBs exhibit high flexible durability and good cycling stability with 93% capacity retention over 200 cycles at −80 °C. The PIL‐OH hydrogel report herein opens up new opportunities for practical applications of wearable and flexible aqueous batteries at ultralow temperature environments, such as the North and South Poles.
Inspired by the antifreezing properties of alcohol cryoprotective agents, a “two‐in‐one” cryoprotective agent, hydroxyl‐functionalized poly(ionic liquid) (PIL‐OH)‐based hydrogel electrolyte, with a low temperature adaptability and high ionic conductivity at −80 °C (0.08 mS cm−1) is prepared. The PIL‐OH hydrogel‐based flexible aqueous lithium‐ion batteries can be operated at an ultralow temperature of −80 °C.
Objective Retrospective analysis and comparison of the effects of Enhanced Recovery After Surgery (ERAS) protocol for patients having left and right colectomy surgeries. Method Out of the patients ...admitted to Chengdu Shang Jin Nan Fu Hospital and West China Hospital from December 2019 to December 2022, a total of 498 who met the inclusion criteria were selected, 255 with right colectomy(RC) and 243 with left colectomy (LC). Under the conditions of strict compliance with ERAS protocol, the relevant physical indexes of RC and LC, including postoperative rehabilitation (especially median post-operative stay) and complications (especially prolonged postoperative ileus, PPOI), were statistically analyzed and compared. Results In terms of intraoperative variables, fluid doses were higher in the LC group than in the RC group ( P < 0.05), and there was no significant difference between them in terms of operative time, blood loss, need for open surgery, peritoneal contamination, epidural catheter placement, or opioid use ( P > 0.05). Compared with the RC group, the LC group had a higher intake of oral liquid at the second postoperative day (POD), and faster first flatulence ( P < 0.05). 30 (11.76%) RC patients required nasogastric tube insertion, while only 3 (1.23%) patients in the LC group required the same ( P < 0.05). Prolonged postoperative ileus (PPOI) occurred in 48 (18.82%) and 29 (11.93%) patients in the RC and LC groups, respectively ( P < 0.05). No significant differences in terms of postoperative complications or length of hospital stay (LoS). stay were observed. Conclusion As the location of colon cancer changes, the effectiveness of ERAS also varies. More personalized and precise ERAS protocols can reduce the incidence of postoperative complications and promote rapid recovery after surgery.
Covalent organic frameworks (COFs) have been proposed as alternative candidates for “smart” materials due to their ordered π-columnar structures. However, it remains a challenge to develop ...external-stimuli-responsive luminescent COFs for confidential information protection. Here, we have designed and synthesized a water-dispersible and smart responsive luminescent carboxymethyl cellulose-COF hydrogel encapsulated 5-(dimethylamino)-N,N-bis (pyridin-2-ylmethyl) napthalene-1-sulfonamide, named CMC-COF-LZU1⊃DPYNS, for latent fingerprint imaging and encryption. We show that the fluorescence of CMC-COF-LZU1⊃DPYNS is reversibly switchable upon addition of Cu2+/H2O. This effect endows potential applications of tunable luminescent COFs based hydrogel as an invisible security probe for imaging, recording, storage, and security of latent fingerprint information. It is shown that the latent fingerprint information incubated by the aptamer-functionalized CMC-COF-LZU1⊃DPYNS hydrogel is invisible in the presence of Cu2+, but three levels of fingerprint features with high-resolution patterns could be readable upon addition of H2O under UV light. The design strategy provides a promising platform for the development of smart responsive luminescent COFs and their detection and protection of valuable latent fingerprint information.
Thermochemical heat storage has been successfully employed as a reliable solution for enhancing the utilisation of renewable energy. In this paper, we report novel composite sorbents fabricated by ...impregnating CaCl2 into porous minerals with different structural properties. Sepiolite (SP), diatomite (DT), and expanded perlite (EP) were chosen as the mesoporous, macroporous, and foamed macroporous matrices, respectively. The pore structure of the matrix exerts a vital influence on the loading of salt hydrates and the performance of the composite material. EP/Ca had the highest energy storage density of 2166 J/g with a water exchange amount of 1.20 g/g, while the energy storage densities of SP/Ca and DT/Ca were 1026 J/g and 1520 J/g, respectively. The foamed macropores of EP provided more space for salt hydrate loading, whereas DT and SP only possessed mesoporous pores with limited pore volumes, thus contributing to lower salt hydrate content. Moreover, EP/Ca exhibited good structural stability during heat storage cycles because of the foamed macroporous structure. In contrast, the restrictive effect of the holes of DT on the salt solution was low, thus causing DT/Ca leakage and caking. Therefore, EP was chosen as the most suitable matrix for supporting salt hydrates. Moreover, this work presents an excellent perspective for exploring new sorption heat-storage materials with low cost, mass production, and high performance.
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•Composite sorbents were obtained by impregnating calcium chloride into matrices with different pore structures.•Mineral materials: sepiolite, diatomite and expanded perlite were innovatively used as matrix materials.•The expanded perlite/calcium chloride had the highest sorption capacity and energy storage density.•Foamed macropores of expanded perlite can avoid solution leakage and improve structural stability of the composite sorbent.
Hydrogel electrolytes are attractive for fabricating flexible supercapacitors (FSCs) due to their relatively high ionic conductivity, adjustable mechanical properties, and easy preparation processes. ...However, they still face challenges such as a narrow operational temperature range due to the presence of abundant free water molecules, and comparatively less favorable electrochemical properties compared to liquid electrolytes. In this study, a redox-active hydrogel electrolyte was synthesized, consisting of polyvinyl alcohol-H2SO4, TiO2 nanoparticles, carbon nanofibers and a mixture of redox-active species (FeBr3, Fe2(SO4)3 and KBr). The addition of thermally stable TiO2 and carbon nanofibers not only increased the thermal stability but also enhanced the ionic conductivity of the hydrogel. The Faradaic reactions of redox-active species during the charging/discharging processes contributed to improved electrochemical performance. Subsequently, binder-free carbon nanofiber@carbon cloth electrodes were prepared by directly growing carbon nanofibers on carbon cloth. By combining the electrodes with the redox-active hydrogel electrolyte, a redox electrolyte-enhanced FSC was assembled. It exhibited a capacitance of 182.8 mF cm−2 at 3.5 mA cm−2, an energy density of 8.3 Wh kg−1, and a capacitance retention of 84.3 % after 5000 charging/discharging cycles. The device was capable of operating under various temperature conditions (0–60 °C) and bending angles (0–180°). Overall, this work provides a novel but facile approach for fabricating FSCs with high electrochemical performance and versatile applications in different environments.
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We propose a new method named OnePose for object pose estimation. Unlike existing instance-level or category-level methods, OnePose does not rely on CAD models and can handle objects in arbitrary ...categories without instance-or category-specific network training. OnePose draws the idea from visual localization and only requires a simple RGB video scan of the object to build a sparse SfM model of the object. Then, this model is registered to new query images with a generic feature matching network. To mitigate the slow runtime of existing visual localization methods, we propose a new graph attention network that directly matches 2D interest points in the query image with the 3D points in the SfM model, resulting in efficient and robust pose estimation. Combined with a feature-based pose tracker, OnePose is able to stably detect and track 6D poses of everyday household objects in real-time. We also collected a large-scale dataset that consists of 450 sequences of 150 objects. Code and data are available at the project page: https://zju3dv.github.io/onepose/.
•The nanoparticles stepwise target tumor cells’ mitochondria to alleviate side effects.•In situ mitochondrial damage and antitumor immune response are achieved efficiently.•Rational precise ...combination therapy can inhibit tumor recurrence and metastasis.
Photothermal therapy (PTT) is a promising therapeutic modality, but still faces some potential limitations, such as unfavorable thermal damage to normal tissues, limited light penetration depth, unpredictable tumor recurrence and metastasis. Additionally, mitochondria play a key role in maintaining multiple cellular functions, whereas displaying fragile thermal sensitivity. Herein, we report on the fabrication of an immunomodulator (R848)-loaded polymeric nanoparticles, R848@cRGD-PDCS, which can spontaneously target mitochondria of tumor cells that benefits from native mitochondria-targeting near-infrared (NIR) light-absorbing moieties. Upon NIR laser irradiation, photothermal-induced mild hyperthermia can efficiently damage the mitochondria in primary tumor cells, promoting efficient release of tumor-associated antigens. Combined with the immune checkpoint blockade (ICB), tumor-mediated immunosuppression can be alleviated, thus the activated antitumor immune response can effectively suppress distant tumors and overcome tumor recurrence and metastasis, achieving long-term antitumor immune memory to inhibit tumor metastasis. Current native mitochondrial targeting phototherapeutic nanoparticles potentiated with immunotherapy are promising for precision translational medicine.
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