Reply de Winter-de Groot, Karin M.; Uiterwaal, Cuno S.P.M.; van der Ent, Cornelis K.
Journal of allergy and clinical immunology,
10/2005, Volume:
116, Issue:
4
Journal Article
Farewell to Han van der Laag van der Ent, Cornelis K.; Noordhoek, Jacquelien; Heijerman, Harry
Journal of cystic fibrosis,
08/2005, Volume:
4
Journal Article
Background: Stunted children with cystic fibrosis (CF) have less net protein anabolism than do children without CF, and the result is retarded growth in the CF patients. It is not known whether ...protein intake above that recommended by the Cystic Fibrosis Foundation would further stimulate whole-body protein synthesis.
Objective: We studied the effects of 3 amounts of protein intake on whole-body protein synthesis and breakdown by using isotopic infusion of 1-13Cvaline and 15N2urea in children with stable CF who required tube feeding.
Design: In 8 pediatric CF patients, we administered 3 randomly allocated isocaloric diets with normal (NP), intermediate (IP), and high (HP) amounts of protein (1.5, 3, and 5 g · kg−1 · d−1, respectively) by continuous drip feeding during a 4-d period at 6-wk intervals. Each patient acted as his or her own control. On the fourth day of feeding, whole-body protein synthesis and breakdown were measured.
Results: Protein synthesis was significantly higher in the HP group ( x̄ ± SEM: 1.78 ± 0.07 μmol · kg−1 · min−1) than in the IP (1.57 ± 0.08 μmol · kg−1 · min−1; P =0.001) and NP (1.37 ± 0.07 μmol · kg−1 · min−1; P < 0.001) groups. There were no significant differences in protein breakdown. Net retention of nitrogen was significantly higher in the HP group (12.93 ± 1.42 μmol · kg−1 · min−1) than in the IP (7.61 ± 1.40 μmol · kg−1 · min−1; P =0.01) and HP (2.48 ± 0.20 μmol · kg−1 · min−1; P < 0.001) groups.
Conclusion: In stunted children with CF requiring tube feeding, the highest stimulation of whole-body protein synthesis was achieved with a short-term dietary protein intake of 5 g · kg−1 · d−1.
One hundred and eighty‐eight surgical patients completed the A‐Trait subscale of a Dutch version of the State‐Trait Anxiety Inventory (STAI‐DY) on the day before the operation and again 3 days later. ...A‐Trait total‐scores were significantly lower in the second measurement (p < .01), and weighted kappa techniques showed disagreement in 8 of 20 pre‐postsurgery items. Nine to 12 months postsurgery, 90 patients completed the measure again. Total‐scores in session 3 were significantly higher than in session 2 (p < .02), and 15 items showed disagreement between both sessions, with more agreement in Anxiety‐present than in Anxiety‐absent items. The ranges of the A‐Trait score‐changes between the different sessions turned out to be rather wide. These results indicate some instability of the A‐Trait subscale of the STAI and argue for a cautious interpretation of individual scores.
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