Study purpose. This research aims to analyze and highlight the potential of bee products in reducing oxidative stress and inflammation after physical activity/exercise.
Materials and methods. This ...research uses a systematic review method by searching various journal databases such as Scopus, Web of Science, PubMed and Embase. The inclusion criteria in this study were articles published in the last 5 years and articles discussing bee products, honey, oxidative stress, inflammation, physical activity, and exercise. The exclusion criteria in this study were articles published in disreputable journals. Titles, abstracts, and full texts of articles were screened then verified and stored in Mendeley software. A total of 7,124 articles from the Scopus, Web of Science, PubMed and Embase databases were identified. A total of 8 articles that met the inclusion criteria were selected and analyzed for this systematic review.
Results. Bee products that have anti-oxidant properties can reduce oxidative stress and the anti-inflammatory properties of bee products can reduce uncontrolled inflammation due to exercise.
Conclusions. Bee products contain flavonoids which have anti-oxidant properties which can reduce oxidative stress. In addition, the anti-inflammatory properties of bee products can reduce uncontrolled inflammation due to physical activity/exercise. In this case, honey works by inhibiting inflammation through NF-κB signals and reducing inflammation by suppressing the secretion of pro-inflammatory cytokines such as TNF-α and inflammatory markers such as CRP. Reducing inflammation can reduce the intensity of muscle pain. It is recommended that bee products be used in individuals to reduce oxidative stress and inflammation after physical activity/exercise.
Bee products have long been used in traditional medicine.The raw materials,crude extracts and purified active compounds from them have been found to exhibil interesting bioactivities,such as ...antimicrobial,anti-inflammatory and antioxidant activities.In addition,they have been widely used in the treatment of many immune-related diseases,as well as in recent times in the treatment of tumors.Bee product peptides induce apoptotic cell death in vitro in several transformed(cancer) human cell lines,including those derived from renal,lung,liver,prostate,bladder and lymphoid cancers.These bioactive natural products may.therefore,prove to be useful as part of a novel targeted therapy for some types of cancer,such as prostate and breast cancer.This review summarizes the current knowledge regarding the in vivo and in vitro potential of selective bee products against tumor cells.
Human activities produce contaminants, the amounts and toxicity of which often exceed the environment's homeostatic capacity to cleanse itself. Hence, the systematic analysis and monitoring of the ...environment is increasingly a matter of urgency. Honey bees, thanks to their morphological features, and also bee products are regarded as good indicators of environmental pollution by toxic substances, be these heavy metals, radioactive elements, or persistent organic pollutants such as pesticides. Bees can carry back to the hive many contaminants deposited on utilitarian plants. The pesticides used in agriculture (especially in spring and summer when farming activities reach their peak) may not only be the cause of the large-scale mortality of bees, but can also get into bee products. The presence of xenobiotics in these products may impair their quality and properties, and put human health at risk. In this article available literature data and information on the morphological features of the honey bee, the utilization of the honey bee and its products as indicators of environmental pollution, and a historical outline of some of the legislation relating to beekeeping have been critically compared and discussed.
Inflammation is a defense process triggered when the body faces assaults from pathogens, toxic substances, microbial infections, or when tissue is damaged. Immune and inflammatory disorders are ...common pathogenic pathways that lead to the progress of various chronic diseases, such as cancer and diabetes. The overproduction of cytokines, such as interleukin (IL)-1β, IL-6, and tumor necrosis factor-α, is an essential parameter in the clinical diagnosis of auto-inflammatory diseases. In this review, the effects of bee products have on inflammatory and autoimmune diseases are discussed with respect to the current literature. The databases of Google Scholar, PubMed, Science Direct, Sci-Finder and clinical trials were screened using different combinations of the following terms: "immunomodulatory", "anti-inflammatory", "bee products", "honey", "propolis", "royal jelly", "bee venom", "bee pollen", "bee bread", "preclinical trials", "clinical trials", and "safety". Honey bee products, including propolis, royal jelly, honey, bee venom, and bee pollen, or their bioactive chemical constituents like polyphenols, demonstrate interesting therapeutic potential in the regulation of inflammatory mediator production as per the increase of TNF-α, IL-1β, IL-6, Il-2, and Il-7, and the decrease of reactive oxygen species (ROS) production. Additionally, improvement in the immune response via activation of B and T lymphocyte cells, both in
and in clinical studies was reported. Thus, the biological properties of bee products as anti-inflammatory, immune protective, antioxidant, anti-apoptotic, and antimicrobial agents have prompted further clinical investigation.
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•Samples: Ethanolic extracts of geopropolis (EEGs) from Brazilian stingless bees.•Biphasic partition methanol/isopropanol (50:50) of EEGs yielded lipid rich fraction.•First time LC ...HRMS and bioinformatic tools used in lipidomic analysis of EEGs.•Findings: several classes of bioactive lipids, 61 compounds accurately identified.•Multivariate analysis indicates marker compounds for each species of stingless bee.
Stingless bees (Meliponini) represent over than 500 species, found in tropical and sub-tropical regions of the world. They produce geopropolis, a resinous natural product containing bioactive compounds, which is commonly used in folk medicine. In the current study, LC-HRMS and bioinformatic tools were used to carry out for the first time the lipidomic analysis of geopropolis from indigenous Brazilian stingless bees. As a result, 61 compounds of several lipid classes were identified with elevated degree of confidence. Then, we demonstrated that lipids in geopropolis are not restricted to waxes and fatty acids; but fatty amides and amines, phenolic lipids, resorcinols, retinoids, abietanoids, diterpenoids, pentacyclic triterpenoids, prostaglandins, retinoids, and steroids were found. In addition, multivariate analysis, based on the lipidomic profile of extracts, reinforces the assumption that the species of stingless bees, as well as the geographical origin are relevant factors to affect geopropolis composition once that the lipidic profile allowed the discrimination of geopropolis in groups related to the geographical origin, bee specie or bee genus. The lipidic profile also suggest a selective forage habits of T. angustula, which seems to collect resins from more specific vegetal sources regardless geographic origin, while other stingless bees, such as M. marginata and M. quadrifasciata, are less selective and may adapt to collect resins from a wider variety of plants.
This study aimed to analyze the influence of adding stingless bee honey (produced by Melipona scutellaris Latrelle - uruçu) on the technological, physicochemical and sensory characteristics of goat ...yogurt containing probiotic Lactobacillus acidophilus La-05 during 28 days of refrigerated storage. Four formulations of goat yogurt were prepared, each varying in the added stingless bee honey amount (0%, 5%, 10% and 15% (v/v), but all inoculated with the probiotic L. acidophilus La-05 (0.1 g/L of goat milk). The incorporation of stingless bee honey positively affected several characteristics in goat yogurt containing L. acidophilus La-05, namely the color, syneresis, viscosity, sensory acceptance and purchase intention. All yogurt formulations presented counts of L. acidophilus La-05 above 6.0 log cfu/g by 28 days of storage, but the presence of honey increased the counts (ca. 1 log cfu/g) of L. acidophilus La-05 and yogurt starter bacteria until 21 days of storage. The results of this study presented a successful incorporation of both the probiotic L. acidophilus La-05 and the honey produced by a native Brazilian stingless bee as ingredients of a new goat dairy product with satisfactory nutritional and sensory quality and added market value because of its potential functional properties.
•Goat yoghurts containing stingless bee honey and/or L. acidophilus were formulated.•Added honey and L. acidophilus influenced positive quality characteristic of goat yoghurt.•Added honey improved technological and sensory attributes of goat yoghurt.•The formulated yoghurt is a suitable vehicle for probiotic L. acidophilus delivery.
The aim of this study was to compare the physichochemical composition of various bee products, namely, bee pollen, beebread, propolis, honey, and royal jelly. The samples (37 out of 53) were ...collected in Lithuania, several samples from other Europe countries (Italy, Denmark, Sweden, Slovakia, Poland, Spain, Republic of Malta, The Netherlands, Latvia, Ukraine) were used for comparison. Various quantities, such as pH, electrical conductivity, oxidation-reduction potential, NaCl content, refraction index, Brix value, total phenolic compound content, total flavonoid content and antiradical activity were measured. Together with the mentioned, the content of micro- and macroelements (As, Ba, Ca, Cd, Co, Cr, Cu, Fe, K, Mg, Mn, Na, Ni, P, Pb, Se, Sr, V and Zn), ultraviolet-visible spectroscopy absorption spectra were analysed. To our knowledge, the literature data about comprehensive comparison of various characteristics of bee products are scarce. Also, to the best of our knowledge, this is the first study revealing mineral content in Lithuanian bee pollen, beebread and royal jelly. The study exposed that bee pollen not only showed the highest values of pH, electrical conductivity and content of soluble solids, but also distinguished from the other samples by the highest flavonoid content (up to 48.3 mg/10 g), the absence of Cr, the presence of Co (0.011-0.100 mg/kg) and Sr (0.73-5.37 mg/kg) and the highest content of Ca (997-2455 mg/kg) and Mg (644-1004 mg/kg). Hierarchical clustering analysis was applied to group the tested samples according to the physicochemical analysis results and mineral content. The clustering analysis revealed that bee pollen formed separate group with the highest distance from the other samples in both cases.
According to the World Health Organization, two billion people will attain the age of 60 years or more by 2050. Ageing is a major risk factor for a number of neurodegenerative disorders, which ...currently possess challenge to the global health status, carrying economic and social consequences. Therefore, attention has been dedicated towards the development of neuroprotective agents derived from natural sources. Honeybee products, such as honey, bee pollen, bee bread, propolis, royal jelly, beeswax, and bee venom have been used for therapeutic purposes since ancient times in Egypt, Greece, and China. Despite the emergence of modern medicine, bee products remain clinically relevant owing to their potential as anti-inflammatory, anti-oxidant, and neuroprotective agents.
This review demonstrates the potential of bee products against neurological disorders in the light of the current literature.
Bee products and individual isolated components have enormous therapeutic potential for multiple neurological disorders. The different studies show overall neuroprotective and nerve-tonic characteristics of bee products, mainly due to their anti-oxidant, anti-inflammatory and anti-apoptotic features. However, some limitations such as allergic reactions and the cytotoxic effect of some bee products warrant a special care in its development as drug leads in future studies.
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•Bee products have antioxidant, anti-inflammatory and anti-apoptotic properties.•Dietary intake of bee products is suggested as a source of neuroprotective agents.•The polyphenols of bee products contribute in preventing neurological disorders.
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