In the run-up to the recent financial crisis, an increasingly elaborate set of financial instruments emerged, intended to optimize returns to individual institutions with seemingly minimal risk. ...Essentially no attention was given to their possible effects on the stability of the system as a whole. Drawing analogies with the dynamics of ecological food webs and with networks within which infectious diseases spread, we explore the interplay between complexity and stability in deliberately simplified models of financial networks. We suggest some policy lessons that can be drawn from such models, with the explicit aim of minimizing systemic risk.
This article presents a new model of culture in action. Although most sociologists who study culture emphasize its role in post hoc sense making, sociologists of religion and social psychologists ...tend to focus on the role beliefs play in motivation. The dual-process model integrates justificatory and motivational approaches by distinguishing between "discursive" and "practical" modes of culture and cognition. The author uses panel data from the National Study of Youth and Religion to illustrate the model's usefulness. Consistent with its predictions, he finds that though respondents cannot articulate clear principles of moral judgment, their choice from a list of moral-cultural scripts strongly predicts later behavior.
The present article highlights the rationale, potential and flexibility of tumor spheroid mono- and cocultures for implementation into state of the art anti-cancer therapy test platforms. Unlike ...classical monolayer-based models, spheroids strikingly mirror the 3D cellular context and therapeutically relevant pathophysiological gradients of in vivo tumors. Some concepts for standardization and automation of spheroid culturing, monitoring and analysis are discussed, and the challenges to define the most convenient analytical endpoints for therapy testing are outlined. The potential of spheroids to contribute to either the elimination of poor drug candidates at the pre-animal and pre-clinical state or the identification of promising drugs that would fail in classical 2D cell assays is emphasised. Microtechnologies, in the form of micropatterning and microfluidics, are also discussed and offer the exciting prospect of standardized spheroid mass production to tackle high-throughput screening applications within the context of traditional laboratory settings. The extension towards more sophisticated spheroid coculture models which more closely reflect heterologous tumor tissues composed of tumor and various stromal cell types is also covered. Examples are given with particular emphasis on tumor-immune cell cocultures and their usefulness for testing novel immunotherapeutic treatment strategies. Finally, tumor cell heterogeneity and the extraordinary possibilities of putative cancer stem/tumor-initiating cell populations that can be maintained and expanded in sphere-forming assays are introduced. The relevance of the cancer stem cell hypothesis for cancer cure is highlighted, with the respective sphere cultures being envisioned as an integral tool for next generation drug development offensives.
Imagined futures, once a vital topic of theoretical inquiry within the sociology of culture, have been sidelined in recent decades. Rational choice models cannot explain the seemingly irrational ...optimism of youth aspirations, pointing to the need to explore other alternatives. This article incorporates insights from pragmatist theory and cognitive sociology to examine the relationship between imagined futures and present actions and experiences in rural Malawi, where future optimism appears particularly unfounded. Drawing from in-depth interviews and archival sources documenting ideological campaigns promoting schooling, the author shows that four elements are understood to jointly produce educational success: ambitious career goals, sustained effort, unflagging optimism, and resistance to temptation. Aspirations should be interpreted not as rational calculations, but instead as assertions of a virtuous identity, claims to be "one who aspires."
This article aims to explore the phenomenon of “classical crossover,” a contemporary music trend that blends “high” and “low” elements. In addition to analyzing the genre’s main features and cultural ...preconditions for its emergence, the article will examine its historical origins and development. The second part of the article focuses on examples of classical crossover in Russian and Ukrainian music, with an analysis of several artists who have ventured into this new type of production, including the Terem Quartet, Anna Netrebko, Olga Chubareva, and Arina Domski. By applying historical and cultural methodology, the article suggests that classical crossover has a broad audience in Russia and Ukraine, allowing musicians to introduce elite classical music to the masses. Although some may view the genre as a dilution of classical music’s distinctive qualities in order to cater to popular tastes, it also provides musicians with the opportunity to create original pieces that merge tradition with innovation. Considering all of the above, the author of this article aims to explore the cultural significance and impact of classical crossover in the music industry.
Using a quasi-experimental research design, this study examines the effect of terrorist events on the perception of immigrants across 65 regions in nine European countries. It first elaborates a ...theoretical argument that explains the effect of events and points to economic conditions, the size of the immigrant population, and personal contact as mediating factors. This argument is evaluated using the fact that the terror attack in Bali on October 12, 2002, occurred during the fieldwork period of the European Social Survey. The findings from this natural experiment reveal considerable cross-national and regional variation in the effect of the event and its temporal duration. The analysis on the regional level supports the argument about contextual variations in the response to the event and a second analysis based on the 2004 Madrid bombing confirms the study's conclusions. Implications of the findings for societal responses to terror attacks, the literature on attitudes toward immigrants, and survey research are discussed. Adapted from the source document.
Thirty microalgal strains were screened in the laboratory for their biomass productivity and lipid content. Four strains (two marine and two freshwater), selected because robust, highly productive ...and with a relatively high lipid content, were cultivated under nitrogen deprivation in 0.6-L bubbled tubes. Only the two marine microalgae accumulated lipid under such conditions. One of them, the eustigmatophyte Nannochloropsis sp. F&M-M24, which attained 60% lipid content after nitrogen starvation, was grown in a 20-L Flat Alveolar Panel photobioreactor to study the influence of irradiance and nutrient (nitrogen or phosphorus) deprivation on fatty acid accumulation. Fatty acid content increased with high irradiances (up to 32.5% of dry biomass) and following both nitrogen and phosphorus deprivation (up to about 50%). To evaluate its lipid production potential under natural sunlight, the strain was grown outdoors in 110-L Green Wall Panel photobioreactors under nutrient sufficient and deficient conditions. Lipid productivity increased from 117 mg/L/day in nutrient sufficient media (with an average biomass productivity of 0.36 g/L/day and 32% lipid content) to 204 mg/L/day (with an average biomass productivity of 0.30 g/L/day and more than 60% final lipid content) in nitrogen deprived media. In a two-phase cultivation process (a nutrient sufficient phase to produce the inoculum followed by a nitrogen deprived phase to boost lipid synthesis) the oil production potential could be projected to be more than 90 kg per hectare per day. This is the first report of an increase of both lipid content and areal lipid productivity attained through nutrient deprivation in an outdoor algal culture. The experiments showed that this marine eustigmatophyte has the potential for an annual production of 20 tons of lipid per hectare in the Mediterranean climate and of more than 30 tons of lipid per hectare in sunny tropical areas. Biotechnol. Bioeng. 2009;102: 100-112.
•Microalgal biofuel studies between 1900 and mid-2015 were analyzed informatically.•Burst interest since 2006–2012 stimulated mass culture and biotechnology studies.•Unremitting study and investment ...is expected for better understanding of microalgae.•Integrated application of energy microalgae could be a possible solution.•Recent advances of approaches to bypass the production bottleneck were reviewed.
Microalgae have reported to be one of the most promising feedstock for biofuel production. To obtain a comprehensive and systematic overview of the current state of microalgal research, particularly microalgal biofuel research, we retrieved and analyzed manuscripts and patents related to this topic and published between 1900 and mid-2015. We found that there was a burst in microalgal biofuel research from 2006 to 2011 that significantly stimulated the development of microalgal biotechnology for the production of high value-added commodities and for environmental applications and microalgal mass culturing, in an attempt to make the entire process of biofuel production economically viable for industrialization. However, a lag in basic microalgal research has kept production costs high, resulting in a decline in investments, funding, and research efforts in the fields of microalgal biofuel production, microalgal biotechnology, and mass culturing since 2012. Based on a review of the challenges/problems of microalgae biofuel production and recent advances of their solution, the perspective view of the future R&D needs and trends were proposed. To bypass the price bottleneck of microalgae-based biofuel production, it has been proposed that energy-producing microalgal biotechnological applications be synergistically combined with microalgal biofuel production. Future investments and funding will most likely be directed toward basic studies that aim to elucidate the microorganisms’ characteristics and toward the development of microalgal biotechnology and its environmental applications, which have potential economic and social benefits. This review represents a theoretical reference for both algal researchers and decision makers regarding the future directions of microalgal research, particularly that involving microalgal-based biofuel production.
PDF
