Objective. This cross-sectional study determines the impact of the pandemic lockdowns on physical activity, and evaluates the factors associated with physical activity cessation on students and ...personnel of eight Greek Higher Education Institutions.
Materials and Methods. A total of 6,380 volunteer participants completed a survey reporting their physical activity levels and perceptions during the COVID-19 pandemic. The survey was made available through an online platform.
Results. Both the conduct and intensity of physical activity were significantly reduced from the pre-pandemic era to the second lockdown (P<0.001). Walking was the most frequently selected type of physical activity, in all periods except for the second lockdown. Loss of interest (52.4%) was the main, self-reported factor for cessation of physical activity. Females had a 31% lower probability of ceasing physical activity during lockdowns.
Conclusion. The conduct and intensity of physical activity decreased significantly during the pandemic. Female gender, annual checkup attendance, and specific physical activity types during the pre-pandemic era were associated with a reduction in the risk of pausing physical activity during lockdowns. Lockdowns may be implemented in future health crises, hence measures for maintaining the physical activity of the general population, such as online group sessions and support from healthcare professionals, should be prepared.
Background: School bags serve as a practical means for students to transport essential academic materials and personal items, including food. The significance of school bag weight has garnered ...increased attention in recent years due to its potential impact on the musculoskeletal health of school children. Excessive school bag weight has been identified as a significant contributor to various health issues, ranging from neck pain and shoulder discomfort to headaches, general fatigue, decreased muscle strength, and, notably, back injuries among children. Methods: The study involved 178 school children in Mangalore, ranging from 10-15 years, for a period of 23 days. School bag weights were measured using calibrated scales, and trunk strength was assessed using a hand held dynamometer. Statistical analysis, including Chi-square test, student’s ‘t’ test and Karl Pearson correlation test were employed to identify any significant relationships between these variables. Results: Preliminary findings revealed a positive correlation between school bag weight and trunk strength among the participants. Results indicated that a considerable proportion (83.1%) of students were burdened with an excessive load of bags. The evaluated muscular strength was discovered to be diminished in these individuals, and they experienced symptoms that were interconnected, highlighting the potential impact of school bag weight on the musculoskeletal health of children in Mangalore. Conclusion: These findings advocate measures to alleviate the burden on children’s musculoskeletal health. Further research and interventions are warranted to promote a balanced and healthy school environment for the well-being of the younger generation.
Height loss in aging has been recognized to reflect a decline in musculoskeletal health but not investigated in relation to dietary factors, such as sugar-sweetened beverages (SSBs), the consumption ...of which may deteriorate musculoskeletal health.
This study aimed to evaluate the longitudinal association of habitual consumption of total SSBs and its subtypes with height loss and examine effect-modification by age, sex, and anthropometry.
We evaluated 16,230 adults aged 40–79 y in the European Prospective Investigation into Cancer and Nutrition-Norfolk cohort. At baseline (1993–1997), SSB consumption (soft drinks, squashes, sweetened milk beverages, sweetened coffee/tea, and sweetened alcoholic beverages) was assessed using 7-d food diaries. Height was objectively measured at the baseline, second (1997–2000), and third (2004–2011) health checks. Multivariable linear regression was used to examine baseline SSB consumption and the rate of height change over the follow-up.
The median (IQR) height change was −1.07 (−2.09 to −0.28) cm/10 y. Adjusted for potential confounders including behavioral factors, medications, and baseline body mass index (BMI), total SSB consumption was associated with height loss (β: −0.024; 95% CI: −0.046, −0.001 cm/10 y per 250 g/d of SSB), and similar results were seen for the individual beverages, except for sweetened milk beverages (β: +0.07; 95% CI: −0.16, 0.30), with wide CIs. No effect-modification by prespecified factors was evident, except for baseline BMI (P-interaction = 0.037). Total SSB consumption was associated with height loss (−0.038; 95% CI: −0.073, −0.004) in participants with BMI ≤ 25 kg/m2 but not apparently in those with BMI > 25 kg/m2.
SSB consumption was modestly associated with height loss, particularly in adults with normal weight status.
An increasing body of evidence highlights the strong potential for a diet rich in fruit and vegetables to delay, and often prevent, the onset of chronic diseases, including cardiometabolic, ...neurological, and musculoskeletal conditions, and certain cancers. A possible protective component, glucosinolates, which are phytochemicals found almost exclusively in cruciferous vegetables, have been identified from preclinical and clinical studies. Current research suggests that glucosinolates (and isothiocyanates) act
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several mechanisms, ultimately exhibiting anti-inflammatory, antioxidant, and chemo-protective effects. This review summarizes the current knowledge surrounding cruciferous vegetables and their glucosinolates in relation to the specified health conditions. Although there is evidence that consumption of a high glucosinolate diet is linked with reduced incidence of chronic diseases, future large-scale placebo-controlled human trials including standardized glucosinolate supplements are needed.
The consequences of SARS-CoV-2 infection on the musculoskeletal system represent a dangerous knowledge gap. Aging patients are at added risk for SARS-CoV-2 infection; therefore, a greater ...understanding of the resulting musculoskeletal sequelae of SARS-CoV-2 infection may help guide clinical strategies. This study examined fundamental bone parameters among mice treated with escalating viral loads. Male C57BL/6J (WT, n = 17) and B6.Cg-Tg(K18-ACE2)2Prlmn/J mice (K18-hACE2 transgenic mice, n = 21) expressing human ACE2 (TG) were divided into eight groups (n = 4–6/group) and subjected to intranasal dosing of 0, 1 × 103, 1 × 104, and 1 × 105 PFU (plaque forming units) of human SARS-CoV-2. Animal health was assessed daily by veterinary staff using established and validated scoring criteria (activity, posture, body condition scores and body weight). We report here that mock and WT infected mice were healthy and completed the study, surviving until 12–14 days post infection (dpi). In contrast, the TG mice infected with 1 × 105 PFU all experienced severe health declines that necessitated early euthanasia (6–7 dpi). For TG mice infected with 1 × 104 PFU, 2 mice were also euthanized after 7 dpi, while 3 mice showed signs of moderate disease at day 6 dpi, but recovered fully by day 11 dpi. Four of the 5 TG mice that were infected with 1 × 103 PFU remained healthy throughout the study. This suggests that our study mimics what is seen during human disease, where some patients develop severe disease resulting in death, while others have moderate to severe disease but recover, and others are asymptomatic. At necropsy, femurs were extracted and analyzed by μCT. No difference was found in μCT determined bone parameters among the WT groups. There was, however, a significant 24.4% decrease in trabecular bone volume fraction (p = 0.0009), 19.0% decrease in trabecular number (p = 0.004), 6.2% decrease in trabecular thickness (p = 0.04), and a 9.8% increase in trabecular separation (p = 0.04) among surviving TG mice receiving any viral load compared to non-infected controls. No differences in cortical bone parameters were detected. TRAP staining revealed surviving infected mice had a significant 64% increase in osteoclast number, a 27% increase in osteoclast surface, and a 38% increase in osteoclasts per bone surface. While more studies are needed to investigate the long-term consequences of SARS-CoV-2 infection on skeletal health, this study demonstrates a significant reduction in several bone parameters and corresponding robust increases in osteoclast number observed within 2 weeks post-infection in surviving asymptomatic and moderately affected mice.
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•Mice surviving SARS-CoV-2 infection exhibit bone loss 12–14 days post-infection.•Mice surviving SARS-CoV-2 infection exhibit increases in TRAP+ osteoclasts.•Bone loss and elevated osteoclasts are seen in mice with no clinical signs of illness.
Objective The prevalence of work-related musculoskeletal injuries is reported to be noticeably high amongst firefighters, which augments the dangers of the job and the difficulties that firefighters ...must face daily. Therefore, this study aimed to firstly determine the prevalence and characteristics of work-related musculoskeletal injuries (MSIs) and musculoskeletal discomfort (MSD) and, secondly, to determine the relationship between MSD and MSIs in firefighters. Methods Using random systematic sampling, 309 firefighters from the City of Cape Town Fire and Rescue Service were recruited to participate. A researcher-generated questionnaire was used to retrieve data on musculoskeletal injuries and musculoskeletal discomfort. Data was analysed using the T-tests, Cochran-Armitage trend test, Jonckheere-Terpstra test, and Binary logistic regression. A p-value of less than 0.05 was used to indicate statistical significance. Results Male (p = 0.036) and older firefighters (p<0.001) with more years of experience (p = 0.002) were most likely to report a musculoskeletal injury. Falls, jumps, slips, and trips were the most common injuries (39.7%), which most often occurred on the fireground (41.1%). Most firefighters (73.3%) reported experiencing discomfort 1-2 times a week of moderate (60.1%) severity that interfered slightly with their ability to work (58.2%). Multivariable analysis showed that the age groups of 40-49 years and 50-65 years and the rank of station commander increased the risk for MSIs by a factor of 2.39, 2.67, and 3.83, respectively. In addition, MSD was associated with an increase in the likelihood of firefighters reporting MSIs (p <0.001). Conclusion Older male firefighters with more years in service were most likely to experience MSIs. Regular physical activity and work-related training should be implemented to increase the fitness for duty and to reduce the prevalence of injuries in firefighters.
Lutein and zeaxanthin are diet-derived carotenoids that are proposed to help mitigate frailty risk and age-related declines in musculoskeletal health via their anti-oxidant and anti-inflammatory ...properties. Therefore, this study aimed to investigate the association between lutein and zeaxanthin status and indices of musculoskeletal health and incident frailty among community-dwelling adults aged ≥50 years in the Irish Longitudinal Study on Ageing (TILDA).
Cross-sectional analyses (n = 4513) of plasma lutein and zeaxanthin concentrations and grip strength, usual gait speed, timed up-and-go (TUG), probable sarcopenia (defined as grip strength <27 kg in men, <16 kg in women), and bone mass (assessed using calcaneal broadband ultrasound stiffness index) were performed at Wave 1 (2009–2011; baseline). In the longitudinal analyses (n = 1425–3100), changes in usual gait speed (at Wave 3, 2014–2015), grip strength (Wave 4, 2016) and TUG (at Wave 5, 2018), incident probable sarcopenia (at Wave 4) and incident frailty (Fried's phenotype, Frailty Index, FRAIL Scale, Clinical Frailty Scale-classification tree, at Wave 5) were determined. Data were analysed using linear and ordinal logistic regression, adjusted for confounders.
Cross-sectionally, plasma lutein and zeaxanthin concentrations were positively associated with usual gait speed (B 95 % CI per 100-nmol/L higher concentration: Lutein 0.59 0.18, 1.00, Zeaxanthin 1.46 0.37, 2.55 cm/s) and inversely associated with TUG time (Lutein −0.07 −0.11, −0.03, Zeaxanthin −0.14 −0.25, −0.04 s; all p < 0.01), but not with grip strength or probable sarcopenia (p > 0.05). Plasma lutein concentration was positively associated with bone stiffness index (0.54 0.15, 0.93, p < 0.01). Longitudinally, among participants who were non-frail at Wave 1, higher plasma lutein and zeaxanthin concentrations were associated lower odds of progressing to a higher frailty category (e.g. prefrailty or frailty) by Wave 5 (ORs 0.57–0.89, p < 0.05) based on the Fried's phenotype, FRAIL Scale and the Clinical Frailty Scale, and in the case of zeaxanthin, Frailty Index. Neither plasma lutein nor zeaxanthin concentrations were associated with changes in musculoskeletal indices or incident probable sarcopenia (p > 0.05).
Higher plasma lutein and zeaxanthin concentrations at baseline were associated with a reduced likelihood of incident frailty after ~8 years of follow up. Baseline plasma lutein and zeaxanthin concentrations were also positively associated with several indices of musculoskeletal health cross-sectionally but were not predictive of longitudinal changes in these outcomes over 4–8 years.
The purpose of this study was to investigate if there is an association between musculoskeletal health literacy with outcome and satisfaction after total knee arthroplasty (TKA).
A cross-sectional ...study was performed at our tertiary center to include patients between one and six years postoperatively after primary TKA. Patients were provided a survey including basic demographics, validated musculoskeletal health literacy scale (Literacy in Musculoskeletal Problems), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and TKA satisfaction (whether they would choose to undergo the same operation again). Patients were categorized as either low or normal health literacy based on number of questions (cutoff 6 out of 9) answered correctly on the Literacy in Musculoskeletal Problems. Statistical analysis included multivariate regression with significance at P < .05.
Four hundred fifty-three individuals fully completed the survey of eligible participants. Two hundred ninety-six individuals (65.3%) had normal health literacy, and one hundred fifty-seven individuals (34.7%) had low health literacy. Average WOMAC (/96) was 18.0 ± 19.7 in the low and 12.1 ± 15.4 in the normal health literacy groups. Patients with low health literacy had significantly higher WOMAC (worse function) than those with normal health literacy (P = .001). Patients with normal musculoskeletal health literacy were significantly more likely to undergo the same operation again (P = .01, odds ratio 2.163).
This study shows that patients with low musculoskeletal health literacy have worse outcome scores and are less likely to be satisfied with their TKA. By identifying these patients preoperatively, emphasis can be placed on enhancing procedure expectations and understanding to improve outcome measures and overall satisfaction.
Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) derived dietary reference values (DRVs) for vitamin D. The Panel considers that ...serum 25(OH)D concentration, which reflects the amount of vitamin D attained from both cutaneous synthesis and dietary sources, can be used as a biomarker of vitamin D status in adult and children populations. The Panel notes that the evidence on the relationship between serum 25(OH)D concentration and musculoskeletal health outcomes in adults, infants and children, and adverse pregnancy‐related health outcomes, is widely variable. The Panel considers that Average Requirements and Population Reference Intakes for vitamin D cannot be derived, and therefore defines adequate intakes (AIs), for all population groups. Taking into account the overall evidence and uncertainties, the Panel considers that a serum 25(OH)D concentration of 50 nmol/L is a suitable target value for all population groups, in view of setting the AIs. For adults, an AI for vitamin D is set at 15 μg/day, based on a meta‐regression analysis and considering that, at this intake, the majority of the population will achieve a serum 25(OH)D concentration near or above the target of 50 nmol/L. For children aged 1–17 years, an AI for vitamin D is set at 15 μg/day, based on the meta‐regression analysis. For infants aged 7–11 months, an AI for vitamin D is set at 10 μg/day, based on trials in infants. For pregnant and lactating women, the Panel sets the same AI as for non‐pregnant non‐lactating women, i.e. 15 μg/day. The Panel underlines that the meta‐regression was done on data collected under conditions of assumed minimal cutaneous vitamin D synthesis. In the presence of cutaneous vitamin D synthesis, the requirement for dietary vitamin D is lower or may even be zero.
This publication is linked to the following EFSA Supporting Publications article: http://onlinelibrary.wiley.com/doi/10.2903/sp.efsa.2016.EN-1078/full
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