Representation literature is rife with the assumption that politicians are responsive to voter preferences because their re‐election is contingent upon the approval of those voters, approval that can ...be won by furthering their desires or, similarly, that can be threatened by ignoring their wishes. Hence, scholars argue that the anticipation of electoral accountability by politicians constitutes a crucial guarantor of (policy) responsiveness; as long as politicians believe that voters are aware of what they do and will take it into account on election day, they are expected to work hard at keeping these voters satisfied. If, on the other hand, politicians were to think what they say and do is inconsequential for citizens’ voting behaviour, they may see leeway to ignore their preferences. In this study, we therefore examine whether politicians anticipate electoral accountability in the first place. In particular, we ask 782 Members of Parliament in Belgium, Germany, Canada and Switzerland in a face‐to‐face survey about the anticipation of voter control; whether they believe that voters are aware of their behaviour in parliament and their personal policy positions, are able to evaluate the outcomes of their political work, and, finally, whether this knowledge affects their vote choice. We find that a sizable number of MPs believe that voters are aware of what they do and say and take that into account at the ballot box. Still, this general image of rather strong anticipation of voter control hides considerable variation; politicians in party‐centred systems (in Belgium and some politicians in Germany that are elected on closed party lists), anticipate less voter control compared to politicians in more candidate‐centred systems (Canada and Switzerland). Within these countries, we find that populist politicians are more convinced that voters know about their political actions and take this knowledge into account in elections; it seems that politicians who take pride in being close to voters (and their preferences), also feel more monitored by these voters. Finally, we show that politicians’ views of voter control do not reflect the likelihood that they might be held to account; politicians whose behaviour is more visible and whose policy profile should therefore be better known to voters do not feel the weight of voter control more strongly.
A series of pre‐stretched double network (DN) polymer films based on agarose and polyacrylamide (Agar/PAM) are prepared. These films show the rapid and large deformation in response to humidity due ...to the release of contraction stress. The pre‐stretched dry film can curl toward the humidity direction into a scroll‐like structure in an extremely short time. The deformation direction can be also well controlled by the stretching direction. The released contraction stress increases with the increase of tensile strain. The DN Agar/PAM hydrogel film shows good water‐induced shape memory effect. It can be stretched to form various temporary shapes such as circle, square, and spiral. The shape fixing and recovery ratios are both close to 100%. The released large contraction stress accelerates the shape recovery process. The recovery time increases with the increase of film thickness. The DN dry film shows the good water‐induced self‐healing ability. The healed film maintains about 88% tensile strength (103 MPa) of the original film. Due to these good properties, the pre‐stretched DN dry films can be fabricated into a soft robot jack which can easily lift up to ≈20 times its own weight within 8 s.
A series of pre‐stretched double network polymer films based on agarose and polyacrylamide are prepared. These films show the controlled, rapid, and large‐scale deformation in response to humidity due to the release of contraction stress. Moreover, these films exhibit the sensitive water‐induced shape memory and self‐healing properties. The rapid shape recovery process is also due to the large contraction stress.
Polyplex for messenger RNA (mRNA) delivery requires strong yet reversible association between mRNA and polycation for extracellular robustness and selective intracellular disintegration. Herein, RNA ...oligonucleotide (OligoRNA) derivatives that bridge mRNA and polycation are developed to stabilize polyplex micelles (PMs). A set of the OligoRNAs introduced with a polyol moiety in their 5' end is designed to hybridize to fixed positions along mRNA strand. After PM preparation from the hybridized mRNA and poly(ethylene glycol)-polycation block copolymer derived with phenylboronic acid (PBA) moieties in its cationic segment, PBA moieties form reversible phenylboronate ester linkages with a polyol moiety at 5' end of OligoRNAs and a diol moiety at their 3' end ribose, in the PM core. The OligoRNAs work as a node to bridge ionically complexed mRNA and polycation, thereby improving PM stability against polyion exchange reaction and ribonuclease attack in extracellular environment. After cellular uptake, intracellular high concentration of adenosine triphosphate triggers the cleavage of phenylboronate ester linkages, resulting in mRNA release from PM. Ultimately, the PM provides efficient mRNA introduction in cultured cells and mouse lungs after intratracheal administration, demonstrating the potential of the bridging strategy in polyplex-based mRNA delivery.
The emergence of logistics and supply chain management as a fully mature business discipline may depend on the development of foundational supply chain management perspectives embracing a focus on ...responsiveness. Hundreds of papers in our field conceptualize responsiveness and related concepts in disconnected ways ignoring this potentially valuable foundation for investigating supply chain strategic and logistical adjustments. Although these extant studies highlight many important issues related to responsiveness, their conceptualizations and nomological networks vary considerably. This diffuse focus seriously hinders efforts to create an overarching theoretical perspective in a dynamic field without one. The result is a masking of promising research directions that could help define the discipline. Drawing from the organizational economics, logistics, and supply chain management literatures, we begin the argument that responsiveness—realized through logistics and supply chain management—has strong potential as our defined foundational perspective. All roads to superior performance depend upon supply chain responsiveness to the environment, supply chain members, stakeholders, and the consumer. Our proposed Responsiveness View of supply chain management supports the exploration of how supply chains compete successfully amidst disruption and change, helping to define a young, theoretically distinct, research domain.
•Asthma patients who carry the AA/AG genotypes of rs2601796 have a greater chance of having a more severe disease.•Furthermore, patients with moderate to severe asthma with those genotypes have worse ...lung function and reduced bronchodilator response.•The risk effect of this genetic variant appears to be due to its impact on the expression of the ADCY9 gene.
Asthma is a respiratory disease caused by the interaction of genetic and environmental factors. The adenylyl cyclase type 9 (ADCY9) enzyme produces the cyclic-adenosinemonophosphate (cAMP), important mediator involved in bronchodilation and immunomodulatory response. The aim of this study was to investigate if rs2601796 and rs2532019 variants in the ADCY9 gene are associated with asthma and lung function. The study comprised 1,052 subjects. Logistic regressions were done using PLINK 1.9 adjusted by sex, age, BMI, smoke and principal components. Bronchodilator responsiveness was assessed using the percentage of difference in FEV1 before and after the bronchodilator use. The in silico analysis for gene expression was performed in the GTEx Portal. The variant rs2601796 (AA/AG genotype) was positively associated with asthma severity (OR: 1.60 IC95%: 1.08–2.39) and with obstruction in individuals with severe asthma (OR: 3.10, IC95%: 1.11–8.62). Individuals with severe asthma and the AA/AG genotype of rs2601796 had less responsiveness to bronchodilators and also a lower expression of ADCY9 in lung and whole blood. The variant rs2532019 (TT/GT genotype) also downregulated the ADCY9 gene expression, but no significant association with the studied phenotypes was found. Thus, the variant in ADCY9 was associated with worse asthma outcomes, including a lower response to bronchodilators, likely due to the impact on its gene expression rate. This variant may be useful in the future to assist in personalized management of patients with asthma.
Broadening the investment model Segal, Noam; Fraley, R. Chris
Journal of social and personal relationships,
08/2016, Volume:
33, Issue:
5
Journal Article
Peer reviewed
The investment model is one of the most influential theoretical frameworks for understanding commitment in close relationships. Nonetheless, few studies have examined commitment dynamics using ...within-persons designs. In addition, there have been few attempts to examine potential antecedents of investment dynamics. The current research attempts to integrate the investment model with contemporary perspectives on attachment and perceived partner responsiveness by examining relationship dynamics within and between persons in a yearlong, intensive longitudinal design. We found that across levels of analysis, perceived partner responsiveness shaped investment model variables which, in turn, shaped commitment. We also found that individual differences in attachment moderated some of these dynamics, such that people who were insecurely attached were less likely than others to perceive their partner as responsive. We suggest taking a more integrationist approach to close relationship research and explore romantic relationship dynamics on the within-person level.
Triple‐functional nanographene oxides described by H. Chen, Y. Li, J. Shi, and co‐workers on page 4386 can circulate within blood vessels to achieve the specific goals of intelligent and efficient ...cancer imaging and chemotherapy, including pH‐responsive drug release to inhibit metastasis and reverse the multidrug resistance of cancer cells, pH‐/redox‐responsive magnetic resonance imaging, and magnetic field‐responsive cancer hyperthermia.
Research Summary
We study the performance implications of dynamic environments for a leader's rivalry‐based imitation efforts in a setting with multiple rivals. We disentangle competitive ...interactions from environmental changes to show that a leader's simple rules to either imitate the closest rival in terms of attributes (her neighbor) or the closest rival in terms of rank (her challenger) can help to maintain the performance gap to her competitors. Using a computational model and an empirical test, we find that environmental changes alter the trade‐offs between imitation accuracy and the responsiveness to threats from distant rivals. Consequently, when environmental changes are infrequent and minor, neighbor imitation is more effective in maintaining the lead, whereas challenger imitation prevails as environmental changes become more frequent and substantial.
Managerial Summary
By showing that imitating a lower‐ranked rival can help a leader to stay ahead, recent research has overturned the common thinking that imitation is only useful for those trying to catch up with the leader. However, these insights come from contexts in which the leader has only one competitor. Can imitation also be effective for a leader competing against multiple rivals, and whom should the leader imitate? We find that imitation can indeed help the leader to maintain their lead against multiple rivals, but that the choice of imitation target matters and should take the competitive environment into account. In relatively stable environments, imitating your most similar rival works best, while imitating whoever is in second place is a more effective approach in changeable environments.
Context: Resilience is the ability to deal with shocks and stresses, including the unknown and previously unimaginable, such as the Covid-19 crisis. Objective: This paper assesses (i) how different ...farming systems were exposed to the crisis, (ii) which resilience capacities were revealed and (iii) how resilience was enabled or constrained by the farming systems' social and institutional environment. Methods: The 11 farming systems included have been analysed since 2017. This allows a comparison of pre-Covid-19 findings and the Covid-19 crisis. Pre-Covid findings are from the SURE-Farm systematic sustainability and resilience assessment. For Covid-19 a special data collection was carried out during the early stage of lockdowns. Results and conclusions: Our case studies found limited impact of Covid-19 on the production and delivery of food and other agricultural products. This was due to either little exposure or the agile activation of robustness capacities of the farming systems in combination with an enabling institutional environment. Revealed capacities were mainly based on already existing connectedness among farmers and more broadly in value chains. Across cases, the experience of the crisis triggered reflexivity about the operation of the farming systems. Recurring topics were the need for shorter chains, more fairness towards farmers, and less dependence on migrant workers. However, actors in the farming systems and the enabling environment generally focused on the immediate issues and gave little real consideration to long-term implications and challenges. Hence, adaptive or transformative capacities were much less on display than coping capacities. The comparison with pre-Covid findings mostly showed similarities. If challenges, such as shortage of labour, already loomed before, they persisted during the crisis. Furthermore, the eminent role of resilience attributes was confirmed. In cases with high connectedness and diversity we found that these system characteristics contributed significantly to dealing with the crisis. Also the focus on coping capacities was already visible before the crisis. We are not sure yet whether the focus on short-term robustness just reflects the higher visibility and urgency of shocks compared to slow processes that undermine or threaten important system functions, or whether they betray an imbalance in resilience capacities at the expense of adaptability and transformability. Significance: Our analysis indicates that if transformations are required, e.g. to respond to concerns about transnational value chains and future pandemics from zoonosis, the transformative capacity of many farming systems needs to be actively enhanced through an enabling environment.
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