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  • Strategies for understandin... Strategies for understanding the role of cellular heterogeneity in the pathogenesis of lung cancer: a cell model for chronic exposure to cigarette smoke extract
    Xia, Dong; Liu, Jieyi; Yong, Juanjuan ... BMC pulmonary medicine, 09/2022, Volume: 22, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Human tumors are highly heterogeneous at the cellular, molecular, genetic and functional levels. Tumor heterogeneity has tremendous impact on cancer progression and treatment responses. However, the ...
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492.
  • Huwe1 Sustains Normal Ovarian Epithelial Cell Transformation and Tumor Growth through the Histone H1.3- H19 Cascade
    Yang, Dong; Sun, Bin; Zhang, Xiaohong ... Cancer research (Chicago, Ill.), 09/2017, Volume: 77, Issue: 18
    Journal Article
    Peer reviewed
    Open access

    Ubiquitination-directed protein degradation is important in many cancers for tumor initiation and maintenance, and E3 ligases containing HECT domains are emerging as new therapeutic targets. In ...
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493.
  • Macrophages Promote Progres... Macrophages Promote Progression of Spasmolytic Polypeptide-Expressing Metaplasia After Acute Loss of Parietal Cells
    Petersen, Christine P; Weis, Victoria G; Nam, Ki Taek ... Gastroenterology (New York, N.Y. 1943), 06/2014, Volume: 146, Issue: 7
    Journal Article
    Peer reviewed
    Open access

    Background & Aims Loss of parietal cells causes the development of spasmolytic polypeptide-expressing metaplasia (SPEM) through transdifferentiation of chief cells. In the presence of inflammation, ...
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494.
  • Intraclonal heterogeneity i... Intraclonal heterogeneity is a critical early event in the development of myeloma and precedes the development of clinical symptoms
    Walker, Brian A; Wardell, Christopher P; Melchor, Lorenzo ... Leukemia, 02/2014, Volume: 28, Issue: 2
    Journal Article
    Peer reviewed
    Open access

    The mechanisms involved in the progression from monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma (SMM) to malignant multiple myeloma (MM) and plasma cell leukemia ...
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495.
  • Metabolism and cancer: the ... Metabolism and cancer: the future is now
    Frezza, Christian British journal of cancer, 01/2020, Volume: 122, Issue: 2
    Journal Article
    Peer reviewed
    Open access

    In the last decade, the field of cancer metabolism transformed itself from being a description of the metabolic features of cancer cells to become a key component of cellular transformation. Now, the ...
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496.
  • The Generalized TP Model Tr... The Generalized TP Model Transformation for T-S Fuzzy Model Manipulation and Generalized Stability Verification
    Baranyi, Peter IEEE transactions on fuzzy systems, 08/2014, Volume: 22, Issue: 4
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    Peer reviewed
    Open access

    This paper integrates various ideas about the tensor product (TP) model transformation into one conceptual framework and formulates it in terms of the Takagi-Sugeno (T-S) fuzzy model manipulation and ...
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497.
  • Remodeling of Channel-Formi... Remodeling of Channel-Forming ORAI Proteins Determines an Oncogenic Switch in Prostate Cancer
    Dubois, Charlotte; Vanden Abeele, Fabien; Lehen’kyi, V’yacheslav ... Cancer cell, 07/2014, Volume: 26, Issue: 1
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    Peer reviewed
    Open access

    ORAI family channels have emerged as important players in malignant transformation, yet the way in which they reprogram cancer cells remains elusive. Here we show that the relative expression levels ...
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498.
  • Wnt signaling in cancer Wnt signaling in cancer
    Zhan, T; Rindtorff, N; Boutros, M Oncogene, 03/2017, Volume: 36, Issue: 11
    Journal Article
    Peer reviewed
    Open access

    Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has most prominently been ...
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499.
  • Reversible and Stepwise Sin... Reversible and Stepwise Single‐Crystal‐to‐Single‐Crystal Transformation of a Platinum(II) Complex with Vapochromic Luminescence
    Saito, Daisuke; Galica, Tomasz; Nishibori, Eiji ... Chemistry : a European journal, June 7, 2022, Volume: 28, Issue: 32
    Journal Article
    Peer reviewed

    The vapochromic single‐crystal‐to‐single‐crystal (SCSC) transformation of a highly luminescent PtII complex bearing an N‐heterocyclic carbene Pt(CN)2(tBu‐impy) ...
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  • Hypoacetylation of acetyl‐h... Hypoacetylation of acetyl‐histone H3 (H3K9ac) as marker of poor prognosis in oral cancer
    Webber, Liana P; Wagner, Vivian P; Curra, Marina ... Histopathology, August 2017, 2017-Aug, 2017-08-00, 20170801, Volume: 71, Issue: 2
    Journal Article
    Peer reviewed

    Aims Epigenetics refers to changes in cell characteristics that occur independently of modifications to the DNA sequence. Oral carcinogenesis is influenced by modifications in epigenetic mechanisms, ...
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