Vitamin D status, measured in a Vitamin D Standardization Program certified laboratory, was assessed among children of South Asian and European ethnicity living in the national capital region of ...Canada to explore factors that may account for inadequate status. Demographic information, dietary and supplemental vitamin D over 30 d prior to measurement of serum 25-hydroxyvitamin D (25OHD), and anthropometry were measured (age 6.0–18.9 y; n = 58/group; February–March 2015). No group related differences in age, height and body mass index (BMI) Z-scores or in food vitamin D intakes were observed. Standardized serum 25OHD was lower in South Asian children (mean ± SD: 39.0 ± 16.8 nmol/L vs. European: 58.4 ± 15.8 nmol/L). A greater proportion of South Asian children had serum 25OHD <40 nmol/L (56.9 vs. 8.6%, P < 0.0001) and fewer took supplements (31 vs. 50%, P = 0.0389). In a multi-factorial model (r
2
= 0.54), lower vitamin D status was associated with overweight/obese BMI and older age (14–18 y); no interaction with ethnicity was observed. Lower vitamin D status was associated with lower total vitamin D intake only in South Asian children. This study reinforces the importance of public health actions towards meeting vitamin D intake recommendations among those of high-risk deficiency.
Novelty:
A higher proportion of South Asian vs. European children had inadequate vitamin D status.
Lower vitamin D status was associated with a BMI in the overweight/obese range.
Lower vitamin D status was associated with lower total vitamin D intake in South Asian but not European children.
The physiological relevance C-3 epimer of 25-hydroxyvitamin D (3-epi-25(OH)D) is not well understood among youth. The objective of this study was to assess whether demographic/physiologic ...characteristics were associated with 3-epi-25(OH)D
3
concentrations in youth. Associations between 3-epi-25(OH)D
3
and demographics and between 3-epi-25(OH)D
3
, total 25-hydroxyvitamin (25(OH)D) (25(OH)D
2
+ 25(OH)D
3
), total cholesterol, high-density lipoprotein, low-density lipoprotein, and triglycerides were examined in racially/ethnically diverse schoolchildren (n = 682; age, 8–15 years) at Boston-area urban schools. Approximately 50% of participants had detectable 3-epi-25(OH)D
3
(range 0.95–3.95 ng/mL). The percentage of 3-epi-25(OH)D
3
of total 25(OH)D ranged from 2.5% to 17.0% (median 5.5%). Males were 38% more likely than females to have detectable 3-epi-25(OH)D
3
concentrations. Both Asian and black race/ethnicity were associated with lower odds of having detectable 3-epi-25(OH)D
3
compared with non-Hispanic white children (Asian vs. white, odds ratio (OR) 0.28, 95% confidence interval (CI) 0.14–0.53; black vs. white, OR 0.38, 95%CI 0.23–0.63, p < 0.001). Having an adequate (20–29 ng/mL) or optimal (>30 ng/mL) 25(OH)D concentration was associated with higher odds of having detectable 3-epi-25(OH)D
3
than having an inadequate (<20 ng/mL) concentration (OR 4.78, 95%CI 3.23–6.94 or OR 14.10, 95%CI 7.10–28.0, respectively). There was no association between 3-epi-25(OH)D
3
and blood lipids. However, when considering 3-epi-25(OH)D
3
as a percentage of total 25(OH)D, total cholesterol was lower in children with percent 3-epi-25(OH)D
3
above the median (mean difference −7.1 mg/dL, p = 0.01). In conclusion, among schoolchildren, sex, race/ethnicity, and total serum 25(OH)D concentration is differentially associated with 3-epi-25(OH)D. The physiological relevance of 3-epi-25(OH)D
3
may be related to the 3-epi-25(OH)D
3
as a percentage of total 25(OH)D and should be considered in future investigations.
Purpose
It is known that vitamin D deficiency has a role in the formation of autoimmune diseases, inflammatory bowel disease, rheumatoid arthritis, multiple sclerosis, diabetes, many types of cancer ...and heart diseases. This study was conducted to demonstrate the role of vitamin D in Hashimoto's thyroiditis.
Methods
In this cross-sectional study, the patients who applied to Izmir Bozyaka Training and Research Hospital endocrinology outpatient clinic between the ages of 16 and 50 were evaluated with ultrasonographically consistent with chronic thyroiditis, serologically antibody positive (anti T, anti M), euthyroid, body mass index (BMI) <30, 40 women with Hashimoto's thyroiditis who did not enter menopause, did not have any other additional disease and did not use chronic medication, and 16-50 women who applied to the internal medicine or endocrinology polyclinics of Izmir Bozyaka Training and Research Hospital 40 healthy female patients with a body mass index (BMI) <30 years and negative for thyroid antibodies were recruited.
Results
When the two groups were compared in terms of age, body mass index, t3, t4, TSH, Anti M, Anti T and vitamin D, no statistically significant difference was found between the two groups. As a result of the Spearman correlation test, no statistically positive or negative correlation was found between vitamin D level and any other parameter (p >0.05).
Conclusion
In conclusion, in this study, it was seen that there may be a relationship between Hashimoto's thyroiditis and vitamin D deficiency. Since vitamin D levels were found to be deficient in the control group, a clear interpretation cannot be made regarding the correlation of Hashimoto's thyroiditis and vitamin D deficiency based on the findings of this study. We hope that our study will be helpful for further studies that will investigate the relationship between autoimmune thyroid diseases and vitamin D deficiency.
Amaç
D vitamini eksikliğinin otoimmün hastalıklar, inflamatuar bağırsak hastalığı, romatoid artrit, multipl skleroz, diyabet, birçok kanser türü ve kalp hastalıklarının oluşumunda rolü olduğu bilinmektedir. Bu çalışma, D vitamininin Hashimoto tiroiditindeki rolünü göstermek için yapılmıştır.
Gereç ve Yöntem
Bu kesitsel çalışmaya 16-50 yaş aralığında İzmir Bozyaka Eğitim ve Araştırma Hastanesi endokrinoloji polikliniğine başvuran ultrasonografik olarak kronik tiroidit ile uyumlu ,serolojik olarak antikor pozitif (anti T, anti M) ,ötiorid ,beden kütle indeksi (BKİ) < 30 olan menapoza girmemiş , herhangi başka ek bir hastalığı ve kronik ilaç kullanımı olmayan 40 Hashimoto tiroditli kadın hasta ile yine İzmir Bozyaka Eğitim ve Araşatırma Hastanesi dahiliye veya endokrinoloji polikliniklerine başvurmuş olan 16-50 yaş aralığında beden kütle indeksi (BKİ) <30 olan 40 sağlıklı, tiiroid antikorları negatif kadın hasta alındı. Obezitenin D vitamini-hormonu ile negatif ilişkisi daha önceden yapılan çalışmalarda gösterilmiş olduğundan çalışmamıza beden kütle indeksi (BKİ) >30 olan Hashimoto tiroiditli veya sağlıklı gönüllüler alınmamıştır.
Bulgular
İki grup yaş, vücut kitle indeksi, t3, t4, TSH, Anti M, Anti T ve D vitamini açısından karşılaştırıldığında iki grup arasında istatistiksel olarak anlamlı fark bulunamadı. Spearman korelasyon testi sonucunda D vitamini düzeyi ile diğer herhangi bir parametre arasında istatistiksel olarak pozitif veya negatif korelasyon bulunamadı (p>0.05).
Sonuç
Sonuç olarak bu çalışmada Hashimoto tiroiditi ile D vitamini eksikliği arasında bir ilişki bulunabileceği görüldü. Kontrol grubunda da D vitamini düzeylerinin eksik bulunmuş olması nedeniyle bu çalısmadaki bulgulara bakarak Hashimoto tiroiditi ile D vitamini eksikliğinin korelasyonu ile ilgili net bir yorum getirilemez. Bizim çalışmamızın otoimmun tiroid hastalıkları ile D vitamini eksikliği arasındaki ilişkiyi daha kapsamlı arastıracak çalışmalar için yardımcı olacağını ummaktayız.
Zusammenfassung
Die topische Behandlung der Psoriasis und ihrer Sonderformen hat einen hohen Stellenwert im Praxisalltag. Sie ist Therapiestandard bei leichter Psoriasis und wird unterstützend auch ...bei mittelschwerer bis schwerer Psoriasis eingesetzt. Bei der Optimierung der Behandlung der Psoriasis spielt neben den geeigneten Wirkstoffen auch die Wahl der Galenik eine entscheidende Rolle. Die Weiterentwicklungen in diesem Bereich wurden in der 2017 publizierten Aktualisierung der S3‐Leitlinie nicht berücksichtigt. Der vorliegende Behandlungspfad wurde im Rahmen der PsoNet‐Sprecherkonferenz erarbeitet und durch die nationale Versorgungskonferenz Psoriasis bestätigt. Er stellt eine Illustration der aktuellen Optionen dar. Die Fachinformationen der genannten Präparate sind dabei stets zu berücksichtigen.
Die Festlegung von Therapiezielen mit dem Patienten ist obligat und adhärenzsteigernd. Dabei sollten die persönlichen Präferenzen und Vorerfahrungen des Patienten berücksichtigt werden. Goldstandard in der Initialphase ist die Fixkombination aus Calcipotriol (Cal) 50 μg/g und Betamethason‐Dipropionat (Bet) 0,5 mg/g 1x täglich über vier bis acht Wochen. Als Darreichungsform ist der Schaum am effektivsten, wobei die individuelle Wahl der Grundlage auch nach Patientenpräferenz erfolgen sollte.
In der Erhaltungsphase hat sich die 1–2x wöchentliche (proaktive) Anwendung dieser Fixkombination bewährt. In zweiter Linie können auch Vitamin D3 Analoga (Calcipotriol, Tacalcitol) und topische Corticosteroide als Monotherapie zur Anwendung kommen. Eine begleitende wirkstofffreie topische Basistherapie sollte regelhaft empfohlen werden. Bei besonderen Therapiesituationen werden spezifische Empfehlungen gegeben. Reicht eine alleinige Lokaltherapie nicht aus, sollte eine Therapieeskalation analog der S3‐Leitlinie zur Therapie der Psoriasis erfolgen.
We investigated a possible association between polymorphisms in vitamin D binding protein (GC) and vitamin D receptor (VDR) genes and obesity in Bahraini adults. For this purpose, 406 subjects with ...varying body mass indexes (BMIs) were selected. Plasma levels of 25-hydroxyvitamin D3 (25OHD3) were measured by chemiluminescence immunoassay. Six single nucleotide polymorphisms, 2 in the VDR gene (rs731236 TC and rs12721377 AG) and 4 in the GC gene (rs2282679 AC, rs4588 CA, rs7041 GT, and rs2298849 TC), were genotyped by real-time polymerase chain reaction. We found that the rs7041 minor allele (G) and rare genotype (GG) were associated with higher BMI (p = 0.007 and p = 0.012, respectively), but they did not influence 25OHD3 levels. However, the minor alleles of rs2282679 (A) and rs4588 (C) were associated with low 25OHD3 plasma levels (p = 0.039 and p = 0.021, respectively), but not with BMI. Having categorized the subjects based on their sex, we found that (i) rs7041 GG associated with high BMI in females (p = 0.003), (ii) rs4588 CC associated with high BMI in females (p = 0.034) and low 25OHD3 levels in males (p = 0.009), and (iii) rs12721377 AA associated with low 25OHD3 levels in females (p = 0.039). Notably, none of the common haplotypes (6 in the GC gene and 3 in the VDR gene) were associated with BMI. Therefore, polymorphisms in the GC (rs2282679, rs4588, rs7041) and VDR (rs12721377) genes were independently associated with obesity and 25OHD3 levels with a clear sex dimorphism.
This study aimed to analyze the impact of light on the amount of 25- hydroxyvitamin D 25-(OH) D in the processed serums of the participants that have been referred to the diagnostic lab (King ...Diagnostic Laboratory) which process tests for around 150 collection sites around ErbiL, Iraq. Scientists and researchers have declared a strong association between vitamin D status and various health issues. Many studies have now shifted to the interaction among/between genes and environment that impact different illnesses correlated with vitamin D. During the periods between 01/April/2020 till 01/April/2021, the total number of cases (N = 5800) of vitamin D content detection in serum have been performed. However, this investigation found that there was a high deficiency (%) in vitamin D levels (nearly 80 %) among the participants contributed to our study and data analysis revealed that they had 25-(OH) D levels very less at 20 μg/L concentration. The amount of vitamin D levels did not vary about with respect to gender and no statistical significance between female and male participants were observed (P > 0.05), moreover, the variation in the group that was subjected to light differed significiantly (P > 0.05). The present research work reveals that there is a significant variation in the use of dark and light collection and testing tube in the process of detecting serum vitamin D levels.
To clarify the association between serum vitamin D levels and its receptor polymorphisms with glaucoma risk.
A meta-analysis was performed from available studies investigating serum vitamin D levels ...and vitamin D receptor (VDR) polymorphisms in glaucoma patients and controls.
Twelve studies in total, including 130,676 and 476 subjects, were analysed for the association between serum vitamin D levels and VDR polymorphisms with glaucoma, respectively. Collectively, it was found that glaucoma patients have lower levels of vitamin D compared to controls (SMD=-1.16, 95% CI=-1.56--0.76, P<0.00001). In parallel, the pooled results showed a significant association between glaucoma and allelic (b vs. B, OR=1.84, 95% CI=1.37-2.46, P=0.00001) and recessive (bb vs. Bb+BB, OR=3.16, 95% CI=1.30-7.66, P=0.001) models of VDR BsmI (rs1544410) polymorphism, but not with VDR TaqI (rs731236) or FokI (rs2228570) polymorphisms.
This meta-analysis suggests that patients with glaucoma may have vitamin D deficiency. In addition, the vitamin D signalling cascade may be a contributing factor in developing glaucoma, which is supported by the evidence that b allele carriers of VDR BsmI exhibited an increase in the risk of glaucoma. Thus, dietary supplementation of vitamin D may become an important approach as an additional treatment for glaucoma.
Vitamin D plays an important role in insulin secretion. As the enzyme that initiates degradation of the active metabolite of vitamin D (1,25-(OH)
2
vitamin D), 24-hydroxylase encoded by CYP24A1 may ...be associated with insulin secretion. In this study, we aimed at investigating the association between copy number of CYP24A1 and the concentration of insulin. Included in the study were 1528 rural people from Henan Province of China. The copy number of CYP24A1 and the concentrations of serum 25(OH) vitamin D
3
and insulin were determined. Association between copy number of CYP24A1 and vitamin D deficiency was investigated with logistic regression model. Correlation between copy number of CYP24A1 and serum insulin was observed by Spearman correlation. The results suggested that copy number variation of CYP24A1 was associated with vitamin D deficiency. Higher copy number of CYP24A1 was a risk factor for vitamin D deficiency (adjusted odds ratio: 1.199; 95% confidence interval: 1.028–1.397; P = 0.021). Furthermore, copy number of CYP24A1 was positive correlated with the concentration of serum insulin (r = 0.115; P < 0.001), regardless of vitamin D status, age, and body mass index (BMI). Increased copy number of CYP24A1 is associated with not only vitamin D deficiency but also increased serum insulin. Vitamin D supplement may be beneficial to individuals with high copy number of CYP24A1.
Novelty
Increased copy number of CYP24A1 was a risk factor of vitamin D deficiency.
Increased copy number of CYP24A1 was associated with increased serum concentration of insulin independent of age, BMI, and vitamin D status.
Osteoarthritis (OA) is a common joint degenerative disease. Vitamin D (VD) is essential for bone health. We hypothesized that active VD could be used as a therapeutic treatment for OA. Low serum ...levels of 25-hydroxyvitamin D 25(OH)D have been found in patients with OA, and thus the serum level of VD could be diagnostic of OA. To test this, we established a mouse model of OA. The results from staining with hematoxylin–eosin and Safranin O – Fast Green indicated that active VD reduced the symptoms of OA in mice. The results from Western blotting indicated that treatment with VD increased the activity of the p-AMPK–AMPK signaling pathway and decreased the p-mTOR–mTOR pathway; it also increased the ratio of LC3II:LC3I antibodies and the protein expression levels of Beclin-1, but decreased the level of p62. Further, treatment with VD reduced the levels of tumor necrosis factor-α and interleukin-6 both in cartilage tissues and in chondrocytes. Administration of the AMPK inhibitor compound C and autophagy inhibitor 3-methyladenine (3-MA) reversed these changes following VD treatment. In addition, the results from transfection with mRFP-GFP-LC3 indicated that active VD led to autophagosome aggregation in OA chondrocytes. 3-MA inhibited cell autophagy and promoted inflammation in OA. This study provides evidence that active VD activate chondrocyte autophagy to reduce OA inflammation via activating the AMPK–mTOR signaling pathway. Treatment with active VD could be a novel therapeutic option for OA.
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