Genetski nadzor inbridiranih linij = Genetic monitoring of inbred strains
Perše, Martina, 1975- ; Horvat, Simon ; Rozman, Damjana, 1960-
Z razvojem molekularne genetike so postale inbridirane linije učinkovito in nepogrešljivo orodje v biomedicinskih raziskavah. Njihova uporabnost sega od raziskovanja osnovnih mehanizmov delovanja ...genov in genskega uravnavanja do razvoja modelov za človeške bolezni, ki so nepogrešljivi pri raziskovanju patofizioloških, biokemičnih in molekularnih mehanizmov nastanka in razvoja bolezni kot tudi pri razvijanju novih terapevtskih sredstev. Zato je povsem razumljivo, da so zahteve po uniformnih in avtentičnih živalih znotraj genetsko standardiziranih linij upravičene in s stališča verodostojnosti rezultatov nujne. Namen prispevka je opoyoriti na potencialne vire genetskega razhajanja med linijami in predstaviti metode, ki se lahko uporabljajo pri genetskem nadzoru glodalcev (predvsem laboratorijskih miši in podgan) tako v vzrejnih kot poskusnih enotah.
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