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Multipli keratoakantomi = Multiple keratoacanthomasLesjak, Vesna, zdravnica ; Orešič-Barać, Tijana ; Miljković, Jovan, 1949-Keratoakantom je pogost epidermalni tumor, histopatološko podoben ploščatoceličnemu karcinomu. Multipli keratoakantomi so heterogena skupina prirojenih ali pridobljenih motenj, v etiopatogenezo ... nastanka naj bi bili vpleteni številni dejavniki, med drugim ultravijolični žarki, ionizirajoče sevanje, virusi (humani virusi papiloma), kemični karcinogeni (katrani), imunološki in genetski dejavniki. V prispevku predstavljamo primere treh bolnikov, pri katerih se dalj časa pojavljajo multipli keratoakantomi, bazalnocelični in ploščatocelični karcinomi kože. Vsi bolniki se več kot 40 let zdravijo zaradi generalizirane luskavice. Večkrat so bili zdravljeni s sistemsko fototerapijo, med zdravljenjem so prejeli visoke kumulativne doze ultravijoličnih žarkov A. Zaradi pojava keratoakantomov je bilo zdravljenje s psoraleni in ultravijoličnimi žarki A pri vseh bolnikih prekinjeno, kljub temu smo še vedno opažali kontinuiran pojav zgoraj omenjenih sprememb. Zaradi pogostih ponovitev luskavice so bolniki v življenju velikokrat izpostavljeni ultravijoličnim žarkom A, kar ima za posledico večjo dovzetnost za pojav nemelanomskih novotvorb. Pojav multiplih keratoakantomov pri predstavljenih bolnikih lahko z veliko verjetnostjo pripišemo dolgotrajni sistemski fotokemoterapiji.Source: Medicinski razgledi : [medicinski pregledni, strokovni in raziskovalni članki]. - ISSN 0025-8121 (Letn. 50, št. 1, mar. 2011, str. 71-77)Type of material - article, component part ; adult, seriousPublish date - 2011Language - slovenianCOBISS.SI-ID - 3873087
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source: Medicinski razgledi : [medicinski pregledni, strokovni in raziskovalni članki]. - ISSN 0025-8121 (Letn. 50, št. 1, mar. 2011, str. 71-77)
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Database name | Field | Year |
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Lesjak, Vesna, zdravnica | ![]() |
Orešič-Barać, Tijana | 25127 |
Miljković, Jovan, 1949- | 16252 |
Source: Personal bibliographies
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