The influence of different ▫$InsP_3$▫ receptor isoforms on ▫$Ca^2+$▫ signaling in tracheal smooth muscle cells
Haberichter, Thomas ...
In airway myocytes, like in many cells, ▫$Ca^{2+}$▫ signaling is controlled byinositol 1,4,5-trisphophate (▫$InsP_3$▫) via ▫$InsP_3$▫ receptors ( ▫$InsP_3R$▫) located in the sarco-endoplasmic ...reticulum. Three types of ▫$InsP_3R$▫ exist, labeled Types 1, 2 and 3, which differ in their gating kinetics. We analyze a possible impact of the different gating kinetics of Type 1 and Type 3 ▫$InsP_3R$▫ on the time course of cytosolic ▫$Ca^{2+}$▫ concetration in tracheal smooth muscle cells upon agonist stimulation. Previous experimental data in rat tracheal myocytes showed that upon gradually increased stimulation with acetylcholine (ACh), a contractile agonist via ▫$InsP_3$▫ production, signal spikes, several spikes with declining maxima, and sustained oscillations appear. Our model reproduces the time courses of cytosolic ▫$Ca^{2+}$▫ measured in tracheal myocytes. Moreover,by postulating slight variations in the model parameters which determine the total number of receptors expressed and the ratio between Type 1 and Type 3 ▫$InsP_3R$▫, it offers an explanation to the experimental observation of qualitatively different responses of cells within a presumably homogeneous tissue
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