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Chung, Mina K; Zidar, David A; Bristow, Michael R; Cameron, Scott J; Chan, Timothy; Harding, 3rd, Clifford V; Kwon, Deborah H; Singh, Tamanna; Tilton, John C; Tsai, Emily J; Tucker, Nathan R; Barnard, John; Loscalzo, Joseph
Circulation research, 04/2021, Volume: 128, Issue: 8Journal Article
A pandemic of historic impact, coronavirus disease 2019 (COVID-19) has potential consequences on the cardiovascular health of millions of people who survive infection worldwide. Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), the etiologic agent of COVID-19, can infect the heart, vascular tissues, and circulating cells through ACE2 (angiotensin-converting enzyme 2), the host cell receptor for the viral spike protein. Acute cardiac injury is a common extrapulmonary manifestation of COVID-19 with potential chronic consequences. This update provides a review of the clinical manifestations of cardiovascular involvement, potential direct SARS-CoV-2 and indirect immune response mechanisms impacting the cardiovascular system, and implications for the management of patients after recovery from acute COVID-19 infection.
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