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Hong, Jie; Guo, Fangfang; Lu, Shi-Yuan; Shen, Chaoqin; Ma, Dan; Zhang, Xinyu; Xie, Yile; Yan, Tingting; Yu, TaChung; Sun, Tiantian; Qian, Yun; Zhong, Ming; Chen, Jinxian; Peng, Yanshen; Wang, Cheng; Zhou, Xiang; Liu, Jianjun; Liu, Qiang; Ma, Xiong; Chen, Ying-Xuan; Chen, Haoyan; Fang, Jing-Yuan
Gut, 11/2021, Volume: 70, Issue: 11Journal Article
Microbiota disorder promotes chronic inflammation and carcinogenesis. High glycolysis is associated with poor prognosis in patients with colorectal cancer (CRC). However, the potential correlation between the gut microbiota and glucose metabolism is unknown in CRC. F-FDG ( F-fluorodeoxyglucose) PET (positron emission tomography)/CT image scanning data and microbiota PCR analysis were performed to measure the correlation between metabolic alterations and microbiota disorder in 33 patients with CRC. Multiple colorectal cancer models, metabolic analysis and Seahorse assay were established to assess the role of long non-coding RNA (lncRNA) enolase1-intronic transcript 1 (ENO1-IT1) in -induced glucose metabolism and colorectal carcinogenesis. RNA immunoprecipitation and chromatin immunoprecipitation sequencing were conducted to identify potential targets of lncRNA ENO1-IT1. We have found . abundance correlated with high glucose metabolism in patients with CRC. Furthermore, supported carcinogenesis via increasing CRC cell glucose metabolism. Mechanistically, activated lncRNA ENO1-IT1 transcription via upregulating the binding efficiency of transcription factor SP1 to the promoter region of lncRNA ENO1-IT1. Elevated ENO1-IT behaved as a guider modular for KAT7 histone acetyltransferase, specifying the histone modification pattern on its target genes, including ENO1, and consequently altering CRC biological function. and glucose metabolism are mechanistically, biologically and clinically connected to CRC. Targeting ENO1 pathway may be meaningful in treating patients with CRC with elevated .
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