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Fanelli, Alessandra; Rapi, Stefano; Dugheri, Stefano; Bonari, Alessandro; Milletti, Eva; Cappelli, Giovanni; Mucci, Nicola; Arcangeli, Giulio
Clinical laboratory (Heidelberg), 01/2020, Volume: 66, Issue: 3Journal Article
The case concerns a 30-year-old woman in the 24th week of pregnancy presenting to the medical emergency room with fever and abdominal pain. Urine sediment microscopy revealed the presence of unknown needle-shaped crystals. Crystals identification was performed by Fourier-Transform Infrared Spectroscopy coupled to Attenuated Total Reflectance (FTIR-ATR). Amoxicillin crystals were verified with semiquantitative results of 87.7%. Drug-induced crystalluria is a frequent finding in urine examination and it may be asymptomatic. FTIR spectroscopy is a rapid and specific tool in identification of crystals and could be useful supporting renal disease diagnosis and monitoring drug therapy.
