E-resources
Peer reviewed
-
Koo, Jahyun; MacEwan, Matthew R; Kang, Seung-Kyun; Won, Sang Min; Stephen, Manu; Gamble, Paul; Xie, Zhaoqian; Yan, Ying; Chen, Yu-Yu; Shin, Jiho; Birenbaum, Nathan; Chung, Sangjin; Kim, Sung Bong; Khalifeh, Jawad; Harburg, Daniel V; Bean, Kelsey; Paskett, Michael; Kim, Jeonghyun; Zohny, Zohny S; Lee, Seung Min; Zhang, Ruoyao; Luo, Kaijing; Ji, Bowen; Banks, Anthony; Lee, Hyuck Mo; Huang, Younggang; Ray, Wilson Z; Rogers, John A
Nature medicine, 12/2018, Volume: 24, Issue: 12Journal Article
Peripheral nerve injuries represent a significant problem in public health, constituting 2-5% of all trauma cases . For severe nerve injuries, even advanced forms of clinical intervention often lead to incomplete and unsatisfactory motor and/or sensory function . Numerous studies report the potential of pharmacological approaches (for example, growth factors, immunosuppressants) to accelerate and enhance nerve regeneration in rodent models . Unfortunately, few have had a positive impact in clinical practice. Direct intraoperative electrical stimulation of injured nerve tissue proximal to the site of repair has been demonstrated to enhance and accelerate functional recovery , suggesting a novel nonpharmacological, bioelectric form of therapy that could complement existing surgical approaches. A significant limitation of this technique is that existing protocols are constrained to intraoperative use and limited therapeutic benefits . Herein we introduce (i) a platform for wireless, programmable electrical peripheral nerve stimulation, built with a collection of circuit elements and substrates that are entirely bioresorbable and biocompatible, and (ii) the first reported demonstration of enhanced neuroregeneration and functional recovery in rodent models as a result of multiple episodes of electrical stimulation of injured nervous tissue.
Author
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.