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Liang, Meng-Yuan; Chen, Ping; He, Miao; Tang, Jian; Li, Hui; He, Xin-Liang; Zhou, Ya-Ya; Feng, Si-Wei; Xue, Yu-E; Liu, Yao; Ma, Yan-Ling; Zhang, Jian-Chu
Current medical science, 02/2021, Volume: 41, Issue: 1Journal Article
The role of corticosteroids in the treatment of Coronavirus disease 2019 (COVID-19) is controversial. In the present study, we evaluated the effects of adjuvant corticosteroids treatment on the outcome of patients with COVID-19 (n=966), using Propensity Score Matching to adjust for potential differences between the corticosteroids group (n=289) and the non-corticosteroids group (n=677). Analysis of data without adjusting differences in baseline characteristics indicated that the proportion of mechanical ventilation and the mortality was higher in the corticosteroids treatment group in total or severe/critical patients. The duration of viral shedding was longer in the non-corticosteroids treatment group in total or general/mild patients. After adjusting the difference between the corticosteroids and non-corticosteroids treatment group, the analysis revealed that the use of corticosteroids had no effect on the duration of viral shedding, in-hospital mortality or 28-day mortality.
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