Reprogramming Tumor‐Associated Macrophages via ROS‐Mediated Novel Mechanism of Ultra‐Small Cu2−xSe Nanoparticles to Enhance Anti‐Tumor Immunity (Adv. Funct. Mater. 12/2022)

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Reprogramming Tumor‐Associated Macrophages via ROS‐Mediated Novel Mechanism of Ultra‐Small Cu2−xSe Nanoparticles to Enhance Anti‐Tumor Immunity (Adv. Funct. Mater. 12/2022)

Zheng, Yanhui; Han, Yaobao; Wang, Tingting; Liu, Hanghang; Sun, Qiao; Hu, Shijun; Chen, Jianquan; Li, Zhen

Advanced functional materials, March 16, 2022, Volume: 32, Issue: 12

Journal Article

Reprogramming Tumor‐Associated Macrophages In article number 2108971, Zhen Li and co‐workers find that ultra‐small Cu2−xSe nanoparticles can effectively polarize tumor‐associated macrophages (TAMs) from the tumor‐supportive M2 phenotype into anti‐tumor M1 phenotype to significantly boost anti‐tumor immunity through a novel mechanism. The nanoparticles can generate reactive oxygen species to trigger polarization through the novel ROS‐TRAF6‐IRF5‐IL‐23 signaling pathway, rather than the classic ROS‐NF‐?B‐iNOS pathway.

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