Purpose of Review Erectile dysfunction, or the inability to achieve penile erection, can be caused by many pharmacological and non-pharmacological factors including smoking, diet, alcohol consumption, obesity, and environmental exposures. Therefore, encouragement of healthy routines can result in great improvement in sexual function. In this review, examples of lifestyle and diet types that burden male sexual function have been addressed in order to encourage healthier lifestyle. Recent Findings Radiant heat, chemical toxins, heavy metals, radio frequency electromagnetic fields, adherence to the Western diet, obesity, lack of exercise, and drug use negatively affect male sexual health through a variety of mechanisms including vascular dysfunction, hormonal dysfunction, and nitric oxide inhibition. Summary This systematic review reveals a captivating role between environmental exposures, dietary patterns, and reproductive and sexual health, especially erectile dysfunction that would serve as comprehensive guide aiding patients’ counseling and management.