A convenient synthesis of the immunosuppressive agent FTY720

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A convenient synthesis of the immunosuppressive agent FTY720

Feng, Xiangjun; Mei, Yuhua; Luo, Yu; Lu, Wei

Monatshefte für Chemie, 2012/1, Volume: 143, Issue: 1

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This paper describes a practical synthetic approach to preparation of an immunosuppressant, FTY720. The key steps involve an iron-catalyzed cross-coupling reaction and a Wittig reaction. The advantages of this synthesis include readily available starting materials, inexpensive reagents, simple operations and good yields. Graphical Abstract

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Feng, Xiangjun | Mei, Yuhua | Luo, Yu | Lu, Wei

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