Over 60 years of research reveal that informants who observe youth in clinically relevant contexts (e.g., home, school)—typically parents, teachers, and youth clients themselves—often hold discrepant views about that client's needs for mental health services (i.e., informant discrepancies). The last 10 years of research reveal that these discrepancies reflect the reality that (a) youth clients' needs may vary within and across contexts and (b) informants may vary in their expertise for observing youth clients within specific contexts. Accordingly, collecting and interpreting multi-informant data comprise “best practices” in research and clinical care. Yet, professionals across settings (e.g., health, mental health, school) vary in their use of multi-informant data. Specifically, professionals differ in how or to what degree they leverage multi-informant data to determine the goals of services designed to meet youth clients' needs. Further, even when professionals have access to multiple informants' reports, their clinical decisions often signal reliance on one informant's report, thereby omitting reports from other informants. Together, these issues highlight an understudied research-to-practice gap that limits the quality of services for youth. We advance a framework—the Needs-to-Goals Gap—to characterize the role of informant discrepancies in identifying youth clients' needs and the goals of services to meet those needs. This framework connects the utility of multi-informant data with the reality that services often target an array of needs within and across contexts, and that making decisions without accurately integrating multiple informants' reports may result in suboptimal care. We review evidence supporting the framework and outline directions for future research. •Service professionals assess youth mental health using multiple informants.•Multiple informants’ reports commonly result in discrepant outcomes.•This paper describes the Needs-to-Goals Gap framework.•This paper links work on informant discrepancies to implementation science.•The framework describes how informant discrepancies impact individual clients.