The principal aim of this study was to develop an analytical scale for domestic tourism motivations and constraints for visiting complex destinations with multiple offerings, containing both cultural and natural assets. A survey was conducted among 454 respondents from Serbia who have experienced multi-attraction destinations in the Lower and Middle Danube region. In part, motives were derived from the studies of Beard and Ragheb (1983), Fodness (1994) and Ryan and Glendon (1998), while the scale of constraints was based on the study of Dong and Chick (2012). Some new motives and constraints were also introduced. The results of exploratory factor analysis (the first phase), indicate four motivating factors (Knowledge and experience, Visiting attractions, Rest and relaxation, Research and prestige) as well as four constraints factors (Structural, Inter/Intrapersonal, Lack of information and recommendation, Lack of time). Finally, while some items were excluded from the scales during the confirmatory factor analysis (the second phase), the analysis confirmed the four-dimensional structure of Multi-attraction travel motivation and constraints scales. •The paper provides a domestic travel motivation and constraints scale.•The scales are applicable to multi-attraction destinations.•The study revealed four motivating factors and four constraints factors.•The motive Visiting attractions can be adopted to fit any multi-attraction destination.