The Time-Sensitive Networking (TSN) set of standards introduces in IEEE 802.1 switches and end stations novel features to meet the requirements of a broad spectrum of applications that are characterized by time-sensitive and mission-critical traffic flows. In particular, the IEEE802.1Qbv-2015 amendment introduces enhancements that provide temporal isolation for scheduled traffic, i.e., a traffic class that requires transmission based on a known timescale, while the IEEE802.1Qbu-2016 introduces preemption as a mechanism to allow time-critical messages to interrupt ongoing non time-critical transmissions. Both amendments, that are now enrolled in the IEEE802.1Q-2018 standard, are very important for industrial networks, where scheduled traffic and low-latency real-time flows have to coexist, on the same network, with best-effort transmissions. In this context, this work presents a response time analysis of TSN networks that encompasses the enhancements for scheduled traffic and preemption, in various combinations. The paper presents the proposed analysis and a performance comparison between the response times calculated by the analysis and the response times obtained through OMNeT++ simulations in three different scenarios. •Present a schedulability analysis of TSN networks with gate mechanism and preemption.•Consider various combinations of TSN features in the schedulability analysis.•Develop a simulation tool in OMNeT++ to evaluate TSN networks with various features.•Compare the analysis and simulation results in three realistic industrial use cases.•Discuss improvement points for the proposed analysis and directions for future work.