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Hossain, M. Shamim; Easmin, Sabina; Islam, M. Saidul; Rashid, Mamunur
Journal of pharmacy and pharmacology, December 2004, Volume: 56, Issue: 12Journal Article
The aim of the present study was to assess the cytotoxic and antimicrobial properties of seven new thiocyanato complexes: Ni(C9H11N2O)(SCN), Cu(C9H11N2O)(SCN), Pd(C9H11N2O)(SCN), Pt(C9H11N2O) (SCN), KTi(C9H11N2O)(SCN)3, Au(C9H11N2O)(SCN), and KV(O)(C9H11N2O)(SCN) (T1‐T7, respectively). All the complexes showed toxicity against brine shrimp nauplii (Artemia salina L.). The titanium‐based complex, T5, exhibited potent toxicity, with a lethal concentration 50% (the concentration of test compound that kills 50% of A. salina) value of 1.59 μg mL−1. These new complexes also exhibited promising antibacterial and antifungal properties. A macrodilution technique was used to estimate the minimum inhibitory concentrations of the seven bioactive complexes. Minimum inhibitory concentrations were found to be 8–64 μg mL−1 against the tested bacterial species.
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