The lack of access to electricity and clean water still affects a substantial proportion of rural areas worldwide, in particular the global south. This paper presents a sustainable polygeneration system that can provide electricity, heat, and drinking water by using agricultural residues in remote rural areas. This polygeneration system consists of a solid biomass-fueled Brayton-Stirling combined cycle system, a boiler, and an air-gap membrane distillation unit. Four different system operation modes were designed to examine the most ideal configurations for maximizing power output, overall efficiency, and/or clean water production, considering a polygeneration system designed for a rural village with daily demands of 13450 kWh electricity and 7.5 m3 drinking water. A thermodynamic analysis are employed to analyze and compare these modes, each operating under steady state conditions. The highest electricity output, up to 160 kW, while the highest clean water is up to 0.7 m3/h. The fuel consumption can reach 0.9 kWh/kg of solid fuel and provide up to 0.0045 m3 of freshwater. In addition, nonlinear multi-objective optimization is used to meet the power demands of typical day in rural areas by varying the polygeneration operation modes and turbine inlet temperature. Display omitted •A solid bio-fuel based polygeneration system is developed for a rural village.•It consists of a Brayton-Stirling cycle, a boiler and a membrane distillation unit.•A thermodynamic study is conducted for comparing four designed operation modes.•Flexible operation can be achieved by combining the four operation modes.•The system can provide 1359 kWh electricity and 7.5 m3 clean water per day.