Reclaimed water is highly required for environmental sustainability and to meet sustainable development goals (SDGs). Chemical processes are frequently associated with highly hazardous and toxic by-products, like nitrosamines, trihalomethanes, haloaldehydes, haloketones, and haloacetic acids. In this context, we aim to summarize the formation of various commonly produced disinfection by-products (DBPs) during wastewater treatment and their treatment approaches. Owing to DBPs formation, we discussed permissible limits, concentrations in various water systems reported globally, and their consequences on humans. While most reviews focus on DBPs detection methods, this review discusses factors affecting DBPs formation and critically reviews various remediation approaches, such as adsorption, reverse osmosis, nano/micro-filtration, UV treatment, ozonation, and advanced oxidation process. However, research in the detection of hazardous DBPs and their removal is quite at an early and initial stage, and therefore, numerous advancements are required prior to scale-up at commercial level. DBPs abatement in wastewater treatment approach should be considered. This review provides the baseline for optimizing DBPs formation and advancements in the remediation process, efficiently reducing their production and providing safe, clean drinking water. Future studies should focus on a more efficient and rigorous understanding of DBPs properties and degradation of hazardous pollutants using low-cost techniques in wastewater treatment. Display omitted •Disinfection is highly required but mostly associated with byproduct formation.•Raw water reported high disinfection byproducts (DBPs) levels than treated water.•UV/Cl2 was reported to be an effective disinfectant for DBPs formation.•Technique to remove nitrosamine precursors from WWTPs is urgently needed.