Social cognitive career theory (SCCT; Lent, Brown, & Hackett, 1994) seeks to explain the factors that shape educational and vocational interests and choices. We used meta-analytic path analyses to synthesize data (from 1981 to 2008) relevant to SCCT’s interest and choice hypotheses, organizing the literature according to Holland’s (1997) broad occupational themes. Sufficient data were available to test (a) a 6-variable version of the interest/choice model in the Realistic, Investigative, and Enterprising themes, and (b) a 4-variable version of the model in the Artistic, Social, and Conventional themes. Analyses of both model versions were generally consistent with theoretical expectations. However, tests of the 6-variable model indicated better support for representing the pathways from contextual variables to choice goals as being partially mediated by self-efficacy and outcome expectations rather than as producing only direct linkages to goals. We consider implications of the findings for theory, research, and SCCT-based interventions.