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Lo, Michael K; Jordan, Robert; Arvey, Aaron; Sudhamsu, Jawahar; Shrivastava-Ranjan, Punya; Hotard, Anne L; Flint, Mike; McMullan, Laura K; Siegel, Dustin; Clarke, Michael O; Mackman, Richard L; Hui, Hon C; Perron, Michel; Ray, Adrian S; Cihlar, Tomas; Nichol, Stuart T; Spiropoulou, Christina F
Scientific reports, 03/2017, Volume: 7, Issue: 1Journal Article
GS-5734 is a monophosphate prodrug of an adenosine nucleoside analog that showed therapeutic efficacy in a non-human primate model of Ebola virus infection. It has been administered under compassionate use to two Ebola patients, both of whom survived, and is currently in Phase 2 clinical development for treatment of Ebola virus disease. Here we report the antiviral activities of GS-5734 and the parent nucleoside analog across multiple virus families, providing evidence to support new indications for this compound against human viruses of significant public health concern.
