Increased expression of lncRNA SNHG7 promotes the cell viability, migration, and invasion in pre-eclampsia via modulating the miR-214-5p/TWIST1 axis

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Increased expression of lncRNA SNHG7 promotes the cell viability, migration, and invasion in pre-eclampsia via modulating the miR-214-5p/TWIST1 axis

Wang, Yongping; Zhang, Zhihui

Hypertension in pregnancy, 07/2021, Volume: 40, Issue: 3

Journal Article

This study is aimed to elucidate the molecular mechanism of lncRNA SNHG7 on pre-eclampsia (PE). The expression of SNHG7, miR-214-5p and TWIST1 in PE placental tissues was detected by qRT-PCR. The regulatory mechanism of SNHG7/miR-214-5p/TWIST1 axis on PE was determined using MTT, wound healing, transwell invasion, and western blot assays. In PE pregnancies, SNHG7 and TWIST1 were decreased, while miR-214-5p was increased.The elevated miR-214-5p and decreased TWIST1 partly eliminated the promoting effects of SNHG7 up-regulation on the viability and metastasis of JEG-3 cells. Up-regulated SNHG7 protects against PE through modulating the miR-214-5p/TWIST1 axi.

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