E-resources
-
Silva, Tiago Fonseca; Cavalcanti Filho, José Robson Neves; Barreto Fonsêca, Mariana Mirelle Lima; Santos, Natalia Medeiros Dos; Barbosa da Silva, Ana Carolina; Zagmignan, Adrielle; Abreu, Afonso Gomes; Sant'Anna da Silva, Ana Paula; Lima, Vera Lúcia de Menezes; Silva, Nicácio Henrique da; Dutra, Lívia Macedo; Almeida, Jackson Roberto Guedes da Silva; Silva, Márcia Vanusa da; Correia, Maria Tereza Dos Santos; Nascimento da Silva, Luís Cláudio
Pharmaceuticals (Basel, Switzerland), 03/2020, Volume: 13, Issue: 3Journal Article
The relevance of oxidative stress in the pathogenesis of several diseases (including inflammatory disorders) has traditionally led to the search for new sources of antioxidant compounds. In this work, we report the selection of fractions with high antioxidant action from (BT) leaf extracts. methods (DPPH and ABTS assays; determination of phenolic and flavonoid contents) were used to select products derived from with high antioxidant action. Then, the samples with the highest potentials were evaluated in a model of injury based on the inoculation of a lethal dose of heat-inactivated in larvae. Due to its higher antioxidant properties, the methanolic extract (BTME) was chosen to be fractionated using Sephadex LH-20 column-based chromatography. Two fractions from BTME (BTFC and BTFD) were the most active fractions. Pre-treatment with these fractions protected larvae of from the stress induced by inoculation of heat-inactivated . Similarly, BTFC and BTFD increased the lifespan of larvae infected with a lethal dose of enteroaggregative 042. NMR data indicated the presence of aliphatic compounds (terpenes, fatty acids, carbohydrates) and aromatic compounds (phenolic compounds). These findings suggested that products derived from leaves are promising candidates for the development of antioxidant and anti-infective agents able to treat oxidative-related dysfunctions.
Author
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.