Nanomolar detection of adenosine triphosphate (ATP) using a nanostructured fluorescent chemosensing ensemble

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Nanomolar detection of adenosine triphosphate (ATP) using a nanostructured fluorescent chemosensing ensemble

Huang, Ling-Xi; Guo, Qing; Chen, Yong; Verwilst, Peter; Son, Subin; Wu, Jia-Bin; Cao, Qian-Yong; Kim, Jong Seung

Chemical communications (Cambridge, England), 12/2019, Volume: 55, Issue: 94

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We report a novel nanostructured chemosensing ensemble PyNp-C13/UD, obtained by self-assembling uranine dye (UD) and an amphiphilic pyridinium salt PyNp-C13. The ensemble was developed for the fluorescence turn-on sensing of ATP in aqueous solutions and inside living cells. The assembly operates via an indicator displacement assay (IDA) method with an ultra-low detection limit of 6.8 nM.

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