Use of normal tissue complication probability models in the clinic

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Use of normal tissue complication probability models in the clinic

Marks, Lawrence B; Yorke, Ellen D; Jackson, Andrew; Ten Haken, Randall K; Constine, Louis S; Eisbruch, Avraham; Bentzen, Søren M; Nam, Jiho; Deasy, Joseph O

International journal of radiation oncology, biology, physics, 03/2010, Volume: 76, Issue: 3 Suppl

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The Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) review summarizes the currently available three-dimensional dose/volume/outcome data to update and refine the normal tissue dose/volume tolerance guidelines provided by the classic Emami et al. paper published in 1991. A "clinician's view" on using the QUANTEC information in a responsible manner is presented along with a description of the most commonly used normal tissue complication probability (NTCP) models. A summary of organ-specific dose/volume/outcome data, based on the QUANTEC reviews, is included.

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