维生素D在克罗恩病中的作用机制及外源性补充作用

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维生素D在克罗恩病中的作用机制及外源性补充作用

夏雨; 周娟; 赵红梅

Zhongguo dang dai er ke za zhi, 08/2023, Volume: 25, Issue: 8

Journal Article

维生素D不仅可调节钙磷代谢,还具有免疫调节的作用.克罗恩病(Crohn's disease,CD)患者普遍缺乏维生素D.研究表明维生素D与CD等自身免疫性疾病有关,通过调节肠道免疫、修复肠黏膜屏障、抑制肠纤维化、增强对英夫利西单抗的应答、调节肠道菌群等途径改善CD患者的病情,促进患者的康复.外源性维生素D补充在提高血清维生素D水平的同时可以诱导疾病的缓解.但目前仅有少数随机双盲、安慰剂对照试验研究维生素D在CD中的治疗效果,有关维生素D最佳的补充形式、具体的补充剂量及需要维持的最佳血清浓度尚未明确.该文主要讨论维生素D在CD的作用机制及外源性维生素D补充对CD的有益作用.

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夏雨 | 周娟 | 赵红梅

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