Coordinated Multi-Point transmission technology which can improve cell edge spectral efficiency and meet the demand of high-speed transmission is one of the key technologies of LTE-Advanced. In this work, we propose a hybrid cell clustering approach in coordinated multi-point transmission system which is more efficient and practical. First, we divide a cell into three sectors: the intra-cell sector, the intra-cluster sector and the inter-cluster sector. Users in these three sectors are designed to utilize the non-coordinated approach, the static coordinated approach, and the dynamic coordinated approach, respectively. Second, we propose a method to identify the user's type in order to choose the best coordinated approach. Finally, we give a resource scheduling method to suit the novel clustering approach. Simulations show that, compared with static clustering and dynamic clustering, our proposed hybrid clustering algorithm can achieve the highest cell edge spectral efficiency.