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Sánchez López, Purificación; Ferrándiz Millón, Elena; Vázquez Gutiérrez, Mercedes
European journal of health research, 04/2016, Volume: 2, Issue: 1Journal Article
The prevalence of overweight and obesity has increased very significantly in recent decades and is a major public health problem in Spain and in most developed countries. Overweight and obesity increase the risk of many other diseases such as cardiovascular disease, insulin resistance, type 2 diabetes, hypertension, dyslipidemia and certain types of cancers. In this context, the increase in life expectancy in our environment, determines that in nursing homes prevalence of diabetes has increased from 16 to 23 percent in the period 1996-2004. In addition there are to take into account that older adults with diabetes suffer from excess morbidity and mortality compared with those without diabetes, which together with its basic characteristics, complicating their management. It is often found in these patients polypharmacy, functional disabilities, as well as geriatric syndromes common as cognitive impairment and risk of falls. Recently it has been marketed lixisenatide (LIX). It is a GLP-1 short-acting. We conducted a study in which we aim to evaluate the effect on glycemic control and other metabolic variables by adding lixisenatide (LIX) a cohort of patients older than 65 years treated with combination therapy of oral agents and basal insulin (BOT). La prevalencia de sobrepeso y obesidad se ha incrementado de una forma muy notable en las últimas décadas y constituye un gran problema de salud pública tanto en España como en la mayoría de los países desarrollados. El sobrepeso y la obesidad incrementan el riesgo de padecer muchas otras patologías como enfermedades cardiovasculares, insulín-resistencia, diabetes tipo 2, hipertensión, dislipemia y ciertos tipos de cánceres. En este contexto, el aumento de la esperanza de vida en nuestro medio, determina que en residencias de ancianos la prevalencia de diabetes haya aumentado del 16 al 23 por ciento en el periodo de 1996-2004. Además hay que tener en cuenta que los adultos mayores con diabetes sufren un exceso de morbilidad y mortalidad en comparación con aquellos sin diabetes, lo que unido a sus características de base, complica su manejo. Es frecuente encontrar en estos pacientes polifarmacia, discapacidades funcionales, así como síndromes geriátricos comunes como deterioro cognitivo y riesgo de caídas. Recientemente se ha comercializado lixisenatide (LIX). Se trata de un análogo de GLP-1 de acción corta. Hemos realizado un estudio en el que nuestro objetivo es evaluar el efecto sobre el control glucémico y otras variables metabólicas mediante la adición de lixisenatide (LIX) a una cohorte de pacientes mayores de 65 años tratados con la terapia de combinación de agentes orales e insulina basal (BOT).
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