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Sahm, Arne; Platzer, Matthias; Koch, Philipp; Henning, Yoshiyuki; Bens, Martin; Groth, Marco; Burda, Hynek; Begall, Sabine; Ting, Saskia; Goetz, Moritz; Van Daele, Paul; Staniszewska, Magdalena; Klose, Jasmin Mona; Costa, Pedro Fragoso; Hoffmann, Steve; Szafranski, Karol; Dammann, Philip
eLife, 03/2021, Volume: 10Journal Article
Sexual activity and/or reproduction are associated with a doubling of life expectancy in the long-lived rodent genus . To investigate the molecular mechanisms underlying this phenomenon, we analyzed 636 RNA-seq samples across 15 tissues. This analysis suggests that changes in the regulation of the hypothalamic-pituitary-adrenal stress axis play a key role regarding the extended life expectancy of reproductive vs. non-reproductive mole-rats. This is substantiated by a corpus of independent evidence. In accordance with previous studies, the up-regulation of the proteasome and so-called 'anti-aging molecules', for example, dehydroepiandrosterone, is linked with enhanced lifespan. On the other hand, several of our results are not consistent with knowledge about aging of short-lived model organisms. For example, we found the up-regulation of the insulin-like growth factor 1/growth hormone axis and several other anabolic processes to be compatible with a considerable lifespan prolongation. These contradictions question the extent to which findings from short-lived species can be transferred to longer-lived ones.
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