Destructive thyroiditis is a self-limited disease characterized by acute release of preformed thyroid hormones. We present a patient with extremely rare acute painful thyroiditis after percutaneous coronary intervention (PCI) in acute myocardial infarction without ST-elevation.The acute onset of thyroid pain and increase of fT3, fT4 and parameters of inflammation were compatible with acute destructive thyroiditis. Such acute thyroiditis probably resulted from local inflammation induced by a large amount of iodine given to the patient via iodinated contrast media used during PCI. Because of the increasing number of patients referred to cardiac catheterization, invasive cardiologists should be aware of the potentially serious thyroid dysfunction that can result from iodinated contrast use. The aim of our paper is, in the light of the patient presented, to discuss the pathophysiology, clinical presentations, therapy and potential preventive measures in patients that develop thyroid dysfunction after PCI. Key words: Acute thyroiditis; Thyrotoxicosis; Percutaneous coronary intervention; Acute coronary syndrome; Iodinated contrast agent Destruktivni tireoiditis samoogranicavajuca je bolest obiljezena akutnim otpustanjem tireoidnih hormona. Prikazujemo bolesnika s akutnim bolnim tireoiditisom nastalim uslijed perkutane koronarne intervencije (PCI) u akutnom koronarnom sindromu bez ST elevacije. Nagla pojava boli u predjelu stitnjace, povecanje vrijednosti fT3 i fT4 te parametara upale bili su konkluzivni s dijagnozom akutnog destruktivnog tireoiditisa. Navedena bolest vjerojatno proizlazi iz lokalne upale izazvane velikom kolicinom joda apliciranog kao jodni kontrast tijekom PCI. Zbog sve veceg broja bolesnika podvrgnutih koronarnoj angiografiji invazivni kardiolozi trebali bi biti svjesni potencijalne opasne disfunkcije stitne zlijezde nastale upotrebom jodnog kontrasta. Cilj naseg rada je, kroz konkretan klinicki slucaj, prikazati i raspraviti o patofiziologiji, klinickoj prezentaciji, terapiji i preventivnim mjerama u bolesnika koji razviju poremecaj rada stitnjace nakon PCI. Kljucne rijeci: Akutni tireoiditis; Tireotoksikoza; Perkutana koronarna intervencija; Akutni koronarni sindrom; Jodni kontrast